Abstract：
:Nano-materials are currently being used in a variety of fields. One of the concerns associated with their use is their potential to harm human health. In an attempt to identify genes expressed differently in human lung cells (WI-26 VA4) exposed to nanosized (45 nm in diameter) PAMAM (polyamidoamine) dendrimers, we observed down-regulation of mitochondrial DNA-encoded genes involved in the maintenance of mitochondrial membrane potential. Down-regulation of gene expression was confirmed by semi-quantitative RT-PCR. Dendrimers were shown to colocalize with mitochondria and cause the release of cytochrome C. Mitochondrial membrane potential was disrupted and the viability of cells was decreased in the presence of dendrimers. Activation of caspases 3 and 9 was increased. Apoptosis was observed by annexin V/propidium iodide staining and DNA fragmentation. In summary, nanosized dendrimers damaged mitochondria resulting in apoptosis.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Lee JH,Cha KE,Kim MS,Hong HW,Chung DJ,Ryu G,Myung Hdoi
10.1016/j.toxlet.2009.07.018subject
Has Abstractpub_date
2009-10-28 00:00:00pages
202-7issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(09)01345-9journal_volume
190pub_type
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