Rotenone and 3-bromopyruvate toxicity impacts electrical and structural cardiac remodeling in rats.

abstract：:Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. In China, it has also been employed in herbal remedies for hepatitis and abdominal edema. Since E. milii latex--lyophilized or in natura--proved to be a potent plant molluscicide, its toxicity to non-target organisms has been comp...

journal_title：Toxicology letters

authors： Delgado IF,De-Carvalho RR,De-Oliveira AC,Kuriyama SN,Oliveira-Filho EC,Souza CA,Paumgartten FJ

更新日期：2003-11-30 00:00:00

abstract：:The effects of linolic acid hydroperoxides (product A) and secondary oxidative products of product A (product B), were examined in an in vivo mid-term test for hepatocarcinogens or hepatopromoters in rats. The number of placental type of glutathione S-transferase (GST-P)-positive foci of the liver was significantly re...

journal_title：Toxicology letters

authors： Hirose M,Thamavit W,Asamoto M,Osawa T,Ito N

更新日期：1986-07-01 00:00:00

abstract：:Checkpoint kinase 1 (Chk1) is required for both intra-S phase and G2/M checkpoints in cell cycle, and plays critical roles in maintaining genomic stability and transducing DNA damage response. Chk1 deficiency has been shown to inhibit T-cell differentiation and resulted in severe anemia in a Chk1 heterozygous mouse mo...

journal_title：Toxicology letters

authors： Hu W,Zong Q,John-Baptiste A,Jessen B

更新日期：2011-07-28 00:00:00

abstract：:1,3-Dinitrobenzene (DNB) causes testicular injury, particularly to Sertoli cells, and induces apoptosis in the surrounding germinal cells in rodents; however, the mechanisms causing this toxicity are poorly understood. Our studies, using standard and molecular tools, were conducted to better understand the pathogenesi...

journal_title：Toxicology letters

authors： Ludwig S,Tinwell H,Rouquié D,Schorsch F,Pallardy M,Bars R

更新日期：2012-09-03 00:00:00

abstract：:Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present...

journal_title：Toxicology letters

authors： Fernández-Blanco C,Frizzell C,Shannon M,Ruiz MJ,Connolly L

更新日期：2016-08-22 00:00:00

abstract：:The cyanobacterial non-proteinogenic amino acid β-N-methylamino-l-alanine (BMAA) is proposed to be involved in the etiology of amyotrophic lateral sclerosis/parkinsonism dementia complex. When administered as single doses to neonatal rats, BMAA gives rise to cognitive and neurodegenerative impairments in the adult ani...

journal_title：Toxicology letters

authors： Andersson M,Karlsson O,Banack SA,Brandt I

更新日期：2016-09-06 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:Inorganic arsenic (As), the most toxic form of As found in water and food, is considered a human carcinogen. Numerous studies show its systemic toxicity, describing pathologies associated with chronic exposure. The main pathway of exposure to inorganic As is oral, but many of the events that occur during its passage t...

journal_title：Toxicology letters

authors： Chiocchetti GM,Vélez D,Devesa V

更新日期：2018-04-01 00:00:00

abstract：:This study was initiated to identify a marker of choice to monitor occupational exposure to toluene through quantitative evaluation of changes in correlation coefficients (CCs), taking advantage of a large database. Six known or proposed exposure markers in end-of-shift blood (B) and urine (U) were studied, i.e., tolu...

journal_title：Toxicology letters

authors： Ikeda M,Ukai H,Kawai T,Inoue O,Maejima Y,Fukui Y,Ohashi F,Okamoto S,Takada S,Sakurai H

更新日期：2008-07-10 00:00:00

abstract：:Transcription factor NF-E2-related factor 2 (NRF2) plays a crucial role in the cellular defense against oxidative/electrophilic stress by up-regulating multiple antioxidant genes. Numerous studies with genetically modified animals have demonstrated that Nrf2 is a sensitivity determining factor upon the exposure to env...

journal_title：Toxicology letters

authors： Jung KA,Choi BH,Nam CW,Song M,Kim ST,Lee JY,Kwak MK

更新日期：2013-03-27 00:00:00

abstract：:Development of a fetus into a phenotypic male depends, first, on testis formation and second, on hormone production by the fetal testis. Disorders of testicular hormone production or action can lead in severe cases to phenotypic abnormalities or can predispose towards impaired reproductive health. Evidence for deterio...

journal_title：Toxicology letters

authors： Sharpe RM

更新日期：2001-03-31 00:00:00

abstract：:Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...

journal_title：Toxicology letters

authors： Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

更新日期：2020-03-01 00:00:00

abstract：:Since cell death by apoptosis is achieved through complex interactions between numerous molecular components, cells may fail to die when stimulated because of molecular abnormalities in the apoptosis pathway or in its control mechanisms. Such inappropriate cell survival is well established when apoptosis is suppressed...

journal_title：Toxicology letters

authors： Williams GT,Critchlow MR,Hedge VL,O'Hare KB

更新日期：1998-12-28 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...

journal_title：Toxicology letters

authors： Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

更新日期：1986-02-01 00:00:00

abstract：:The tobacco smoking habit interferes with the innate host defence system against infections. Recurrent infections accelerated the functional respiratory decline. The present study assessed the effects of ceftaroline on TLR2 and TLR4 and on pro-inflammatory responses in airway epithelial cells (16HBE cell line and prim...

journal_title：Toxicology letters

authors： Pace E,Ferraro M,Di Vincenzo S,Siena L,Gjomarkaj M

更新日期：2016-09-06 00:00:00

abstract：:It has been reported that lead could induce apoptosis in a variety of cell types. Although mitochondrion is regarded as the most pertinent pathway in mediating apoptosis, the exact mechanisms of lead-induced apoptosis are still largely unknown. Furthermore, there is little information about expressions and regulations...

journal_title：Toxicology letters

authors： Xu J,Ji LD,Xu LH

更新日期：2006-10-10 00:00:00

abstract：:Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential o...

journal_title：Toxicology letters

authors： Patel R,Rosengren RJ

更新日期：2001-05-31 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00

abstract：:Adrenal weight and the concentration of corticosterone and glucose in plasma of male Wistar rats, dosed orally with fenitrothion (7.25 or 14.5 mg/kg/day) for 28 days were investigated. A significant increase in the relative weight of adrenals was observed 2 weeks after treatment commenced, but was preceded by an incre...

journal_title：Toxicology letters

authors： Yamamoto T,Egashira T,Yoshida T,Kuroiwa Y

更新日期：1982-04-01 00:00:00

abstract：:The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. H...

journal_title：Toxicology letters

authors： Nandan SD,Rao MS

更新日期：1982-11-01 00:00:00

abstract：:Cimetidine, a widely prescribed, potent histamine H2-receptor antagonist, is unrelatedly a mild antiandrogen. Since perinatal androgens are essential for normal masculine imprinting, we wanted to determine if maternally administered cimetidine interfered with the development of the male offspring's sex-dependent, hepa...

journal_title：Toxicology letters

authors： Shapiro BH,Bitar MS

更新日期：1991-01-01 00:00:00

abstract：:Primary cultures of rat hepatocytes were exposed to various concentrations of L-asparaginase derived from Escherichia Coli. Protein synthesis was inhibited by about 33% and cellular glutamine was reduced proportionally to the enzyme concentration. However, protein synthesis was inhibited only by amounts of enzyme able...

journal_title：Toxicology letters

authors： Villa P,Corada M,Bartosek I

更新日期：1986-09-01 00:00:00

abstract：:Isolated rat hepatocytes incubated aerobically formed measurable amounts of ethane, a parameter for lipid peroxidation. This ethane formation increased several-fold due to carbon tetrachloride (CCl4) depending on its concentration. Cell damage as measured by trypan blue uptake and lactate dehydrogenase release poorly ...

journal_title：Toxicology letters

authors： de Ruiter N,Ottenwälder H,Muliawan H,Kappus H

更新日期：1981-06-01 00:00:00

abstract：:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...

journal_title：Toxicology letters

authors： Matsukura M,Koike K,Zon G

更新日期：1995-12-01 00:00:00

abstract：:The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared wi...

journal_title：Toxicology letters

authors： Nilsson BO,Einarsson B,Magnusson C

更新日期：1991-05-01 00:00:00

abstract：:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...

journal_title：Toxicology letters

authors： Tanaka T

更新日期：1992-05-01 00:00:00

abstract：:Due to the massive reduction of air-change rates in modern, energy-saving houses and dwellings, the contribution of volatile organic compound (VOCs) emissions from wood-based materials to indoor air quality has become increasingly important. To evaluate toxicity of VOC mixtures typically emitted from pine wood and ori...

journal_title：Toxicology letters

authors： Gminski R,Tang T,Mersch-Sundermann V

更新日期：2010-06-16 00:00:00

abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

journal_title：Toxicology letters

authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

更新日期：1986-12-01 00:00:00

abstract：:Several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (EDCs). In three pair-matched studies we found changes in sex hormone concentrations and T-lymphocytes in relation to acute and chronic pesticide exposure. After acute exposure, 1 day later the concentrati...

journal_title：Toxicology letters

authors： Straube E,Straube W,Krüger E,Bradatsch M,Jacob-Meisel M,Rose HJ

更新日期：1999-06-30 00:00:00