Abstract:
:The effect of sodium selenite administered acutely or repeatedly on the biochemical components of the hepatic microsomal monooxygenase enzyme system was examined in male rats. 72 h following acute administration of selenium (2.4 mg Se/kg, i.p.), there was a significant decrease in ethylmorphine-N-demethylase activity and cytochrome P-450 levels but no change in aniline hydroxylase or NADPH cytochrome c reductase activity. Following repeated administration of selenite in the drinking water (1, 2, or 4 ppm Se) for 30 days, there was no alteration in any of the parameters measured. Following the in vitro additions of selenite to microsomes obtained from untreated rats, ethylmorphine-N-demethylase and aniline hydroxylase activities were inhibited at selenium concentrations of 10(-4) M or greater, but the inhibition achieved was less than 50%. No alterations in cytochrome P-450 levels were observed. These results indicate that selenium is a rather weak, indirect, and substrate-specific inhibitor of the hepatic monooxygenase enzyme system.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Schnell RC,Early JL,Deimling MJ,Merrick BA,Davies MHdoi
10.1016/0378-4274(83)90057-7subject
Has Abstractpub_date
1983-06-01 00:00:00pages
193-200issue
1-2eissn
0378-4274issn
1879-3169pii
0378-4274(83)90057-7journal_volume
17pub_type
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