Abstract:
:The effect of sorbic acid alone and in combination with sodium nitrite has been studied on bone marrow chromosomes of mice following 30 days oral treatment. Bone marrow of mice exposed to sorbic acid (15 mg/kg) and sorbic acid nitrite (7.5-1 mg/kg) showed an increase in mitotic index indicating that the drugs had an effect on spindle apparatus. Sorbic acid effected spindle activity but did not damage chromosomes, whereas nitrite itself was clastogenic. However, a combination of half the concentration each of sorbic acid (15 mg/kg) and sodium nitrite (2 mg/kg) together gave synergistic effects, which may be ascribed to the formation of some genotoxic compound in vivo.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Banerjee TS,Giri AKdoi
10.1016/0378-4274(86)90002-0subject
Has Abstractpub_date
1986-05-01 00:00:00pages
101-6issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(86)90002-0journal_volume
31pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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