Effects of diethylene glycol butyl ether and butoxyethoxyacetic acid on rat and human erythrocytes.

Abstract:

:The toxicity of diethylene glycol butyl ether (DGBE), and its principal metabolite, butoxyethoxyacetic acid (BEAA), were assessed in vitro for rat and human red blood cells. Rat erythrocytes showed evidence of mild hemolysis when exposed to BEAA at concentrations of 5 or 10 mM for 4 h. BEAA treated rat red blood cells also showed evidence of sub-hemolytic damage: increased spherocytosis, a shift in distribution of cell size to larger cells, a significant increase in mean cellular volume, and a decrease in cellular deformability. However, DGBE had no effect on rat red blood cell morphology, cell size, hemolysis or deformability. There was no hemolysis when human red blood cells were exposed to DGBE or BEAA at the same concentrations. No changes in mean cellular volume, distribution of cell size, or morphologic appearance of human red blood cells were observed. No evidence for decreased deformability of human red blood cells exposed to DGBE or BEAA was found. In conclusion, BEAA has weak hemolytic activity and sub-hemolytic effects in vitro on rat erythrocytes, which is consistent with the finding of mild hemolysis when the parent compound DGBE is administered to rats by gavage. The absence of hemolysis or sub-hemolytic damage when human red blood cells were exposed to BEAA or DGBE in vitro indicates that it is unlikely that hemolysis will occur as a result of human exposure to DGBE.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Udden MM

doi

10.1016/j.toxlet.2003.09.021

keywords:

subject

Has Abstract

pub_date

2005-03-28 00:00:00

pages

95-101

issue

1

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(04)00460-6

journal_volume

156

pub_type

杂志文章
  • Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

    abstract::In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.014

    authors: Gohlsch K,Mückter H,Steinritz D,Aufderheide M,Hoffmann S,Gudermann T,Breit A

    更新日期:2019-11-01 00:00:00

  • The disruption of L-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells.

    abstract::L-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H₂O₂), were characterized with lower l...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.03.019

    authors: Lemire J,Mailloux R,Darwich R,Auger C,Appanna VD

    更新日期:2011-06-24 00:00:00

  • Molecular failure of apoptosis: inappropriate cell survival and mutagenesis?

    abstract::Since cell death by apoptosis is achieved through complex interactions between numerous molecular components, cells may fail to die when stimulated because of molecular abnormalities in the apoptosis pathway or in its control mechanisms. Such inappropriate cell survival is well established when apoptosis is suppressed...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00343-9

    authors: Williams GT,Critchlow MR,Hedge VL,O'Hare KB

    更新日期:1998-12-28 00:00:00

  • Cadmium chloride-induced changes in hypothalamic 5-hydroxytryptamine, noradrenaline and dopamine levels in the Indian palm squirrel, Funambulus pennanti (Wroughton).

    abstract::A single intraperitoneal injection of cadmium chloride (CdCl2, 0.32 mg/kg body weight) was administered to 15 adult female palm squirrels (Funambulus pennanti (Wroughton] and the hypothalamic 5-hydroxytryptamine (5-HT), noradrenaline (NA) and dopamine (DA) levels were quantified on the 1st, 7th and 40th day. 5-HT leve...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90082-3

    authors: Shrivastava VK,Sathyanesan AG

    更新日期:1988-05-01 00:00:00

  • Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.

    abstract::The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effect of the OP Crotylsarin (CRS) on respir...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.07.005

    authors: Klein-Rodewald T,Seeger T,Dutschmann M,Worek F,Mörschel M

    更新日期:2011-09-25 00:00:00

  • Effects of smoking on spontaneous and induced sister chromatid exchanges in lymphocytes.

    abstract::Spontaneous and mitomycin C-induced sister chromatid exchanges (SCEs) in lymphocytes were analyzed in 24 non-smokers and 24 sex- and age-matched smokers. Mean spontaneous SCE frequency for non-smokers was 9.8 SCEs/cell, and that for smokers was 11.5 SCEs/cell. The difference was statistically significant (P less than ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90210-3

    authors: Nagaya T,Toriumi H

    更新日期:1985-06-01 00:00:00

  • Inter- and intra-individual variation in urinary biomarker concentrations over a 6-day sampling period. Part 1: metals.

    abstract::The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individu...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.08.014

    authors: Smolders R,Koch HM,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R,Hays SM,Aylward LL

    更新日期:2014-12-01 00:00:00

  • Dimethylacetamide pharmacokinetics following inhalation exposures to rats and mice.

    abstract::Whole-body inhalation exposures to N,N-dimethylacetamide (DMAC) were conducted with male rats (Crl:CD BR) and mice (Crl:CD-1 (ICR)BR). Exposure concentrations were 50, 150, 300 and 500 ppm. The exposure routines consisted of single 1-, 3-, or 6-h exposures and ten 6-h exposures (10 exposure days in 2 weeks). Area unde...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90061-2

    authors: Hundley SG,Lieder PH,Valentine R,McCooey KT,Kennedy GL Jr

    更新日期:1994-09-01 00:00:00

  • Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice.

    abstract::The deposition of excess or abnormal collagen characteristic of pulmonary fibrosis can disrupt gas exchange resulting in severe respiratory impairment. There currently are no effective pharmacologic agents available that inhibit the fibrotic process. Pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) is an investigationa...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(96)03845-3

    authors: Kehrer JP,Margolin SB

    更新日期:1997-02-07 00:00:00

  • Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats.

    abstract::The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We re...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.11.009

    authors: Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo A

    更新日期:2017-01-04 00:00:00

  • Comparison of the toxicity of methylcyclopentadienyl manganese tricarbonyl with that of its two major metabolites.

    abstract::Pneumotoxicity and lethality resulting from administration of methylcyclopentadienyl manganese tricarbonyl (MMT) and its 2 major metabolites in rats were compared. Following i.p. injection, MMT was found to have an LD50 value of 12.1 mg/kg. Neither of the metabolites appeared to have significant acute toxicity even wh...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90250-5

    authors: Cox DN,Traiger GJ,Jacober SP,Hanzlik RP

    更新日期:1987-11-01 00:00:00

  • Effects of chlordimeform on heart rate and body temperature of unanesthetized, unrestrained rats.

    abstract::Heart rate (HR) and body core temperature (Tco) were monitored in unanesthetized, unrestrained adult Sprague-Dawley rats following intraperitoneal administration of 0, 10, 30, or 60 mg/kg of the pesticide chlordimeform (CDM). Significant non-dose-related decreases were observed in both HR and Tco in all treated groups...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90208-6

    authors: Watkinson WP,Gordon CJ

    更新日期:1987-02-01 00:00:00

  • Influence of maternal restraint stress on the long-lasting effects induced by prenatal exposure to perfluorooctane sulfonate (PFOS) in mice.

    abstract::The behavioral effects of concurrent maternal exposure to restraint stress and perfluorooctane sulfonate (PFOS) were assessed in the offspring of mice at 3 months of age. Plug positive females were divided into two groups. Animals were given by gavage 0 and 6mg PFOS/kg/day on gestation days 12-18. One-half of the anim...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2007.05.006

    authors: Fuentes S,Colomina MT,Vicens P,Domingo JL

    更新日期:2007-07-10 00:00:00

  • A novel in vivo model for predicting myelotoxicity of chemotherapeutic agents using IL-3/GM-CSF transgenic humanized mice.

    abstract::Evaluating myelotoxicity is essential for ensuring the safety of novel drugs before they are approved for clinical applications. Although in vivo prediction of the maximum tolerated doses (MTDs) of anticancer drugs is usually performed in rodents, the results are not always applicable to clinical treatment because dru...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.09.013

    authors: Ito R,Nagai D,Igo N,Okuda Y,Sekine K,Ichimura E,Katano I,Mizushima T,Goto M,Ohnishi Y,Ito M,Okamoto K

    更新日期:2017-11-05 00:00:00

  • Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice.

    abstract::Saikosaponin-d (SSd), one of the main constituents of the total saikosaponins extracted from Bupleurum falcatum L, possesses anti-inflammatory and anti-apoptosis effect. Recently, SSd was proved to improve depressive symptoms although exhibit hepatotoxicity in animals, but the central nervous system (CNS) toxicity of ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.11.009

    authors: Lixing X,Zhouye J,Liting G,Ruyi Z,Rong Q,Shiping M

    更新日期:2018-03-01 00:00:00

  • Airway responses during and directly after single-time exposure to ozone.

    abstract::Breathing pattern and lung mechanical parameters were measured in 7 female Wistar rats (ca. 200 g) during exposure to 1.0 (n = 5) or 1.3 (n = 2) ppm ozone in air for 2 h and during a 2-h post-exposure observation period. Changes in breathing pattern showed a gradual decrease from 3 to 2 Hz at constant minute ventilati...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90036-1

    authors: Zwart A,Arts JH

    更新日期:1994-06-01 00:00:00

  • ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells.

    abstract::Nickel (Ni) can disorder testosterone synthesis in rat Leydig cells, whereas the mechanisms remain unclear. The aim of this study was to investigate the role of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) in Ni-induced disturbance of testosterone synthesis in rat Leydig cells. The testo...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.03.016

    authors: Han A,Zou L,Gan X,Li Y,Liu F,Chang X,Zhang X,Tian M,Li S,Su L,Sun Y

    更新日期:2018-06-15 00:00:00

  • Comparison between oral and dermal bioavailability of soil-adsorbed phenanthrene in female rats.

    abstract::Phenathrene is a major coal tar component found in hazardous waste disposal sites. The purpose of this study was to evaluate the extent to which phenanthrene adsorption to either of 2 different soils affects the manner in which phenanthrene is subsequently handled in orally and dermally exposed adult female rats. Abso...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(95)03250-o

    authors: Kadry AM,Skowronski GA,Turkall RM,Abdel-Rahman MS

    更新日期:1995-07-01 00:00:00

  • Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells.

    abstract::Humans are typically exposed to mixtures of substances, whereby their bioactivity can be significantly altered by co-occurring compounds. Thus, over the last years, research on combinatory effects has gained increasing attention. In particular, several xenoestrogens have been recently reported to interact synergistica...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.10.025

    authors: Aichinger G,Pantazi F,Marko D

    更新日期:2020-02-01 00:00:00

  • Inhibition of store-operated Ca(2+) channels prevent ethanol-induced intracellular Ca(2+) increase and cell injury in a human hepatoma cell line.

    abstract::Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.11.007

    authors: Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

    更新日期:2012-02-05 00:00:00

  • Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups.

    abstract::Oxidative stress has been pointed as an important molecular mechanism for liver injury in methylmercury (MeHg) poisoning. Ebselen, a seleno-organic compound that possesses anti-oxidant properties, is a useful therapeutic agent used in clinical situations involving oxidative stress. Here, we examined the possible in vi...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2003.10.001

    authors: Farina M,Soares FA,Zeni G,Souza DO,Rocha JB

    更新日期:2004-02-02 00:00:00

  • Methylmercury impairs motor function in early development and induces oxidative stress in cerebellar granule cells.

    abstract::Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and youn...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2013.08.002

    authors: Patel E,Reynolds M

    更新日期:2013-10-09 00:00:00

  • 1,3-Propane sultone, an extremely potent experimental carcinogen: what should be expected in humans?

    abstract::1,3-Propane sultone is directly alkylating, genotoxic and carcinogenic. In rats, it induces local and systemic tumours at multiple target sites. Preponderant systemic tumours occur at the central nervous system, especially gliomas. Other localisations include the mammary gland, the intestine, the haematopoietic system...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2003.12.073

    authors: Bolt HM,Golka K

    更新日期:2004-06-15 00:00:00

  • Determination of mercury in hair of children.

    abstract::Although high or repeated exposure to different forms of Hg can have serious health consequences, the most important toxicity risk for humans is as methylmercury (MeHg) which exposure is mainly through consumption of fish. Generally, more than the 80% of Hg in hair is as MeHg, which is taken up by hair follicles as Me...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.06.1215

    authors: Pino A,Bocca B,Forte G,Majorani C,Petrucci F,Senofonte O,Alimonti A

    更新日期:2018-12-01 00:00:00

  • Guanidinoacetic acid (GAA) synthesis in rat tubular suspension as a system for evaluating gentamicin (GM) nephrotoxicity.

    abstract::Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA syn...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(95)03411-0

    authors: Takeda M,Jung KY,Sekine T,Endou H,Koide H

    更新日期:1995-11-15 00:00:00

  • Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model.

    abstract::Clinical epidemiological studies have shown that there is a link between Parkinson's disease (PD) and cancer, but how PD regulates cancer development remains unknown. In our study, the effect of metabotropic glutamate receptor 5 (mGlu5) on hepatoma was explored in a rotenone-induced PD model both in vitro and in vivo....

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.02.019

    authors: Bai XX,Gu L,Yang HM,Xi SS,Xia N,Zhang S,Zhang H

    更新日期:2018-05-15 00:00:00

  • Influence of liver S-9 preparations from rats and rainbow trout on the activity of four mutagens.

    abstract::The mutagenicity of four chemical compounds to strain TA100 of S. typhimurium was affected differently by liver S-9 preparations from untreated Sprague-Dawley rats and from rainbow trout (Salmogairdneri). These two species were equally effective in decreasing the direct mutagenicity of sodium dichromate. Rat preparati...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90228-4

    authors: de Flora S,Zanacchi P,Bennicelli C,Arillo A

    更新日期:1982-03-01 00:00:00

  • Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice.

    abstract::Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days sub...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90141-9

    authors: Rattner BA,Michael SD

    更新日期:1985-01-01 00:00:00

  • Sulfotransferases: genetics and role in toxicology.

    abstract::The mammalian xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a gene superfamily (SULT). Ten distinct human SULT forms are known. Two SULT forms represent splice variants, the other forms are encoded by separate genes. Common functional polymorphisms of the transcribed region are known for ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(99)00214-3

    authors: Glatt H,Engelke CE,Pabel U,Teubner W,Jones AL,Coughtrie MW,Andrae U,Falany CN,Meinl W

    更新日期:2000-03-15 00:00:00

  • Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency.

    abstract::Cadmium (Cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. Previously, we have shown that Cd activated mitogen-activated protein kinases and that sulfur amino acid deficiency potentiated Cd-induced cytotoxicity vi...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(03)00233-9

    authors: Kim SC,Cho MK,Kim SG

    更新日期:2003-10-15 00:00:00