Antisense phosphorothioates as antivirals against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

Abstract:

:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activities of phosphorothioate oligodeoxynucleotides (S-oligo) were classified into sequence non-specific (non-antisense) and sequence specific (antisense). We found that toxicity of S-oligo could be also classified into the same 2 categories. Since some of non-specific toxicity is dependent on experimental conditions, in each experiment, we should pay attention to minimize non-specific toxicity of the oligomers.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Matsukura M,Koike K,Zon G

doi

10.1016/0378-4274(95)03574-5

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

435-8

eissn

0378-4274

issn

1879-3169

pii

0378-4274(95)03574-5

journal_volume

82-83

pub_type

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