Ethane formation of isolated rat hepatocytes due to carbon tetrachloride.

abstract：:Malathion was applied to roses in three Finnish greenhouses by hand held lance sprayers. The potential dermal exposure of applicators to this insecticide was measured. Total urine production of each applicator was also collected up to 24 h post application. In the urine samples the specific metabolite of malathion, ma...

journal_title：Toxicology letters

authors： Tuomainen A,Kangas JA,Meuling WJ,Glass RC

更新日期：2002-08-05 00:00:00

abstract：:Cadmium-binding proteins (CdBPs) in the cytosol fractions from several organs of man orally exposed to cadmium (Cd) were examined by gel chromatography. In kidney and liver most of the cadmium (76-87%) in the cytosols was bound to metallothionein, and hepatic metallothionein contained zinc also at a similar level. The...

journal_title：Toxicology letters

authors： Sato M,Takizawa Y

更新日期：1982-05-01 00:00:00

abstract：:Trihalomethanes (THMs; chloroform, bromoform, bromodichloromethane, dibromochloromethane), formed as by-products of chlorine disinfection, are found to occur in combination in drinking water supplies. THMs are metabolized by cytochromes P-450 and are likely substrates of CYP2E1. Therefore, it is possible that mixed ex...

journal_title：Toxicology letters

authors： Luciene da Silva M,Charest-Tardif G,Krishnan K,Tardif R

更新日期：1999-05-20 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are widespread environmental pollutants, and the levels of certain congeners have been increasing in biota and abiota in recent decades. Some PBDEs are lipophilic and persistent, resulting in bioaccumulation in the environment. Their structural similarity to other polyhalogenated...

journal_title：Toxicology letters

authors： Peters AK,Sanderson JT,Bergman A,van den Berg M

更新日期：2006-07-01 00:00:00

abstract：:A direct continuous spectrophotometric assay to measure pyrethroid-cleaving enzymes in human serum was developed using cis- and trans-alpha-naphthyl-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate (cis- and trans-naphthyl-Cl2CA). These substrates show a structure very similar to the pyrethroids most often use...

journal_title：Toxicology letters

authors： Butte W,Kemper K

更新日期：1999-06-30 00:00:00

abstract：:Male Sprague-Dawley rats were treated i.p. with different doses of bromobenzene (0, 0.1, 0.2, 0.3 and 0.5 mmol/kg) in corn oil for 4 weeks. The animals were killed 24 h after the end of the treatment for hepatic drug metabolism studies. A significant induction of the activities of microsomal aniline hydroxylase (51%) ...

journal_title：Toxicology letters

authors： Chakrabarti S

更新日期：1984-01-01 00:00:00

abstract：:There have been many concerns about the possible adverse effects of thyroid hormone-disrupting chemicals in the environment. Because thyroid hormones are essential for regulating the growth and differentiation of many tissues, disruption of thyroid hormones during the neonatal period of an organism might lead to perma...

journal_title：Toxicology letters

authors： Fujimoto N,Kitamura S,Uramaru N,Miyagawa S,Iguchi T

更新日期：2018-04-01 00:00:00

abstract：:Groups of people with no occupational exposure to Br-containing chemicals (29-54 year old, mostly women) in Japan, China and Korea, respectively, offered spot urine samples. Those in China and Korea offered 24 h duplicates of foods of the day. Urine samples were analyzed for Br by ECD-gas chromatography (ECD-GC) after...

journal_title：Toxicology letters

authors： Kawai T,Zhang ZW,Moon CS,Shimbo S,Watanabe T,Matsuda-Inoguchi N,Higashikawa K,Ikeda M

更新日期：2002-08-05 00:00:00

abstract：:Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, we investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult male Lo...

journal_title：Toxicology letters

authors： Ruppert PH,Dyer RS

更新日期：1985-11-01 00:00:00

abstract：:Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....

journal_title：Toxicology letters

authors： Wang X,You SH,Lien KW,Ling MP

更新日期：2019-10-10 00:00:00

abstract：:Due to its ability to avidly accumulate methyl mercury from blood, scalp hair has been widely used as a biological monitor for human exposure. The question arises that hair may also be an important route of elimination of methyl mercury from the body. Taking original publications and reviews on the physiology of hair ...

journal_title：Toxicology letters

authors： Magos L,Clarkson TW

更新日期：2008-11-10 00:00:00

abstract：:One of the major side effects of aminoglycoside antibiotics (AG) is ototoxicity. The authors review the literature revealing many controversies on every aspect of this side-effect. Although epidemiological studies have to face the problem of reliable evaluation techniques, the incidence of cochleo- and vestibulotoxic ...

journal_title：Toxicology letters

authors： Govaerts PJ,Claes J,van de Heyning PH,Jorens PG,Marquet J,De Broe ME

更新日期：1990-08-01 00:00:00

abstract：:Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. In order to evaluate the complex relationship between the genotoxicity and the AhR-mediated activity of...

journal_title：Toxicology letters

authors： Hrubá E,Vondráček J,Líbalová H,Topinka J,Bryja V,Souček K,Machala M

更新日期：2011-10-10 00:00:00

abstract：:Due to the massive reduction of air-change rates in modern, energy-saving houses and dwellings, the contribution of volatile organic compound (VOCs) emissions from wood-based materials to indoor air quality has become increasingly important. To evaluate toxicity of VOC mixtures typically emitted from pine wood and ori...

journal_title：Toxicology letters

authors： Gminski R,Tang T,Mersch-Sundermann V

更新日期：2010-06-16 00:00:00

abstract：:We observed transient excretion of dark-brown urine after acute exposure to cobalt in rats and investigated the mechanism of it. We injected cobalt into rats s.c. at a dose of 15 mg/kg and collected urine, peripheral blood, and organ samples at the indicated times after injection. Biochemical and histopathological exa...

journal_title：Toxicology letters

authors： Horiguchi H,Oguma E,Nomoto S,Arao Y,Ikeda K,Kayama F

更新日期：2004-08-01 00:00:00

abstract：:Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds....

journal_title：Toxicology letters

authors： Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon P

更新日期：2014-03-03 00:00:00

abstract：:In present study, we compared for the first time the cytotoxicities of the 16 priority polycyclic aromatic hydrocarbons (PAHs) in human pulmonary alveolar epithelial cells HPAEpiC. Moreover, we examined the effects of each PAH on oxidative stress (SOD, GSH, and ROS), cell viability, extracellular LDH, and apoptosis. T...

journal_title：Toxicology letters

authors： Ke S,Liu Q,Yao Y,Zhang X,Sui G

更新日期：2018-06-15 00:00:00

abstract：:The co-ordinated glucuronidation and export of compounds from cells is an important determinant in the detoxification of many compounds in vivo. Many UDP-glucuronosyltransferases (UGTs) and several multidrug resistance proteins (MRPs) have been cloned and individually expressed to assess specificity of glucuronidation...

journal_title：Toxicology letters

authors： Cuff RL,Wade LT,Rychlik B,Jedlitschky GA,Burchell B

更新日期：2001-03-31 00:00:00

abstract：:Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...

journal_title：Toxicology letters

authors： Nogawa K,Yamada Y,Honda R,Ishizaki M,Tsuritani I,Kawano S,Kato T

更新日期：1983-07-01 00:00:00

abstract：:In this study, we aimed to evaluate the genotoxic effects of fungicides fenarimol and propamocarb which are used to protect crops from fungi. For this reason, bone-marrow micronucleus and chromosome aberration tests were carried out in Swiss albino mice. Mice were injected with four different doses of fenarimol and pr...

journal_title：Toxicology letters

authors： Aydemir N,Bilaloğlu R

更新日期：2004-02-28 00:00:00

abstract：:The common food preparation processes, frying, broiling and baking, can give rise to air pollutants that are known to be mutagenic and carcinogenic in animal tests. A large number of persons can be exposed to such fumes as cooking is performed in most households and in many commercial enterprises. Additional studies o...

journal_title：Toxicology letters

authors： Löfroth G

更新日期：1994-06-01 00:00:00

abstract：:Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-...

journal_title：Toxicology letters

authors： Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

更新日期：2021-01-08 00:00:00

abstract：:Exposure of humans to xenobiotic mixtures is a continuous state during their everyday routine. However, the majority of toxicological studies assess the in vivo effects of individual substances rather than mixtures. Therefore, our main objective was to evaluate the impact of the 12- and 18-month exposure of rats to a ...

journal_title：Toxicology letters

authors： Fountoucidou P,Veskoukis AS,Kerasioti E,Docea AO,Taitzoglou IA,Liesivuori J,Tsatsakis A,Kouretas D

更新日期：2019-12-15 00:00:00

abstract：:Several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (EDCs). In three pair-matched studies we found changes in sex hormone concentrations and T-lymphocytes in relation to acute and chronic pesticide exposure. After acute exposure, 1 day later the concentrati...

journal_title：Toxicology letters

authors： Straube E,Straube W,Krüger E,Bradatsch M,Jacob-Meisel M,Rose HJ

更新日期：1999-06-30 00:00:00

abstract：:The clinical use of gentamicin (G) is limited because of its nephrotoxic potential. The administration of G (50 mg/kg) to rats in a 10-day daily treatment gave a biphasic pattern of lactate dehydrogenase (LDH) and N-acetyl-beta-D-glucosaminidase (NAG) excretion. Alkaline phosphatase (ALP) was highly elevated during th...

journal_title：Toxicology letters

authors： Obatomi DK,Plummer DT

更新日期：1995-01-01 00:00:00

abstract：:Voltage-activated sodium channels and GABAA receptor-chloride channel complex are among the most important target sites of various environmental neurotoxicants. Pyrethroids keep the sodium channels open for prolonged periods of time leading to hyperexcitation of the entire nervous system. In rat cerebellar Purkinje ne...

journal_title：Toxicology letters

authors： Narahashi T,Carter DB,Frey J,Ginsburg K,Hamilton BJ,Nagata K,Roy ML,Song JH,Tatebayashi H

更新日期：1995-12-01 00:00:00

abstract：:Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final ma...

journal_title：Toxicology letters

authors： Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

更新日期：2000-03-15 00:00:00

abstract：:Exposure to polychlorinated biphenyls (PCBs) induce a broad spectrum of toxic effects in various organs including bone. The most susceptible age-groups to the toxic effects of PCBs are foetuses and infants. The aim of the present study was to quantitatively evaluate changes in bone geometry, mineral density and biomec...

journal_title：Toxicology letters

authors： Elabbas LE,Herlin M,Finnilä MA,Rendel F,Stern N,Trossvik C,Bowers WJ,Nakai J,Tuukkanen J,Viluksela M,Heimeier RA,Akesson A,Håkansson H

更新日期：2011-11-10 00:00:00

abstract：:Toxicity of an aqueous extract prepared from Echinodorus macrophyllus dried leaves, a plant used in folk medicine to treat inflammation and kidney malfunctions, was estimated by different bioassays. Mutagenicity of the aqueous extract was evaluated in the Salmonella/microsome assay (TA97a, TA98, TA100 and TA102 strain...

journal_title：Toxicology letters

authors： da Costa Lopes L,Albano F,Augusto Travassos Laranja G,Marques Alves L,Fernando Martins e Silva L,Poubel de Souza G,de Magalhães Araujo I,Firmino Nogueira-Neto J,Felzenszwalb I,Kovary K

更新日期：2000-08-16 00:00:00

abstract：:The effects of linolic acid hydroperoxides (product A) and secondary oxidative products of product A (product B), were examined in an in vivo mid-term test for hepatocarcinogens or hepatopromoters in rats. The number of placental type of glutathione S-transferase (GST-P)-positive foci of the liver was significantly re...

journal_title：Toxicology letters

authors： Hirose M,Thamavit W,Asamoto M,Osawa T,Ito N

更新日期：1986-07-01 00:00:00