Effect of 2-amino-9H-pyrido[2,3-b]indole (AalphaC), a carcinogenic heterocyclic amine present in food, on atherosclerotic plaque development in apoE deficient mice.

abstract：:Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

journal_title：Toxicology letters

authors： Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

更新日期：2012-02-05 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00

abstract：:Due to the specific antimicrobial activity of silver nanoparticles (AgNPs), they are widely used in wound dressings, coatings in medical devices and household products. In spite of the well-documented genotoxicity of AgNPs, the molecular mechanisms of relieving AgNP-induced DNA damage stress remain poorly understood. ...

journal_title：Toxicology letters

authors： Wang D,Yang H,Zhou Z,Zhao M,Chen R,Reed SH

更新日期：2018-05-15 00:00:00

abstract：:Aluminum phosphide (AlP), a widely used fumigant and rodenticide leads to high mortality if ingested. Its toxicity is due to phosphine liberated when it comes in contact with moisture. The exact mechanism of action of phosphine is not known. In this study male Wistar rats were used. The animals received a single dose ...

journal_title：Toxicology letters

authors： Anand R,Kumari P,Kaushal A,Bal A,Wani WY,Sunkaria A,Dua R,Singh S,Bhalla A,Gill KD

更新日期：2012-11-23 00:00:00

abstract：:Whole-body inhalation exposures to N,N-dimethylacetamide (DMAC) were conducted with male rats (Crl:CD BR) and mice (Crl:CD-1 (ICR)BR). Exposure concentrations were 50, 150, 300 and 500 ppm. The exposure routines consisted of single 1-, 3-, or 6-h exposures and ten 6-h exposures (10 exposure days in 2 weeks). Area unde...

journal_title：Toxicology letters

authors： Hundley SG,Lieder PH,Valentine R,McCooey KT,Kennedy GL Jr

更新日期：1994-09-01 00:00:00

abstract：:Di-(2-propylheptyl) phthalate (DPHP) is used as a plasticizer for polyvinyl chloride products. A tolerable daily intake of DPHP of 0.2 mg/kg body weight has been derived from rat data. Because toxicokinetic data of DPHP in humans were not available, it was the aim of the present work to monitor DPHP and selected metab...

journal_title：Toxicology letters

authors： Klein D,Kessler W,Pütz C,Semder B,Kirchinger W,Langsch A,Gries W,Otter R,Gallien AKE,Wurzenberger X,Filser JG

更新日期：2018-09-15 00:00:00

abstract：:Anti-androgenic chemicals alter sexual differentiation by a variety of mechanisms, and the mechanisms between phthalate esters and p,p'-DDE are considered to be different. We performed an in utero through lactational exposure assay using dicyclohexyl phthalate and p,p'-DDE to investigate the sexual differentiation of ...

journal_title：Toxicology letters

authors： Yamasaki K,Okuda H,Takeuchi T,Minobe Y

更新日期：2009-08-25 00:00:00

abstract：:1,3,5-Trinitro-2-acetyl pyrrole (TNAP) is a product derived from the reaction of 2-acetyl pyrrole with nitrite in the model of Maillard browning systems. This compound is moderately mutagenic to the Salmonella strains TA98 and TA100 and is markedly cytotoxic to mouse C3H10T1/2 cells. Experiments are performed to inves...

journal_title：Toxicology letters

authors： Lin YL,Tseng TH,Hsu JD,Chu CY,Wang CJ

更新日期：1996-12-16 00:00:00

abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...

journal_title：Toxicology letters

authors： Kleinman MT,Araujo JA,Nel A,Sioutas C,Campbell A,Cong PQ,Li H,Bondy SC

更新日期：2008-05-05 00:00:00

abstract：:Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...

journal_title：Toxicology letters

authors： Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

更新日期：2020-03-01 00:00:00

abstract：:Methanol remains to be a major public and environmental health hazard. Formic acid is the toxic metabolite responsible for the metabolic acidosis observed in methanol poisoning in humans, in non-human primates and in folate-depleted rodents. Cytochrome oxidase inhibition by formate leads to lactic acid accumulation, w...

journal_title：Toxicology letters

authors： Muthuvel A,Rajamani R,Sheeladevi R

更新日期：2006-02-20 00:00:00

abstract：:We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

journal_title：Toxicology letters

authors： Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

更新日期：2001-03-08 00:00:00

abstract：:Safety assessment procedures still rely heavily if not exclusively on the results of tests carried out in laboratory animals, then extrapolated to man. There are few examples of environmental compounds examined extensively enough in both man and animals to permit a critical comparison of the accuracy of such risk asse...

journal_title：Toxicology letters

authors： Guzelian PS

更新日期：1992-12-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major problem in drug development. Although some in vitro methods assessing DILI risk that utilize hepatic cell death or cellular stress as markers have been developed, the predictive ability of these tests is low. In this study, we sought to develop a novel cell-based assay for t...

journal_title：Toxicology letters

authors： Oda S,Matsuo K,Nakajima A,Yokoi T

更新日期：2016-01-22 00:00:00

abstract：:The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination behaviour in simple solutions and assess the effects of complex formation upon skin permeatio...

journal_title：Toxicology letters

authors： Staff K,Brown MB,Chilcott RP,Hider RC,Jones SA,Kong XL

更新日期：2011-05-10 00:00:00

abstract：:Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...

journal_title：Toxicology letters

authors： Imai T,Onose J,Hasumura M,Takizawa T,Hirose M

更新日期：2006-06-20 00:00:00

abstract：OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chrom...

journal_title：Toxicology letters

authors： Hulo S,Chérot-Kornobis N,Howsam M,Crucq S,de Broucker V,Sobaszek A,Edme JL

更新日期：2014-04-07 00:00:00

abstract：:Potentiality of a protective effect of methionine against hepatotoxic action of vinyl chloride (VC) was assessed on rats, induced with phenobarbital and thereafter exposed to 50 000 ppm VC for 5 h. This extremely high dosage of VC warranted the appearance of drastic symptoms of liver injury in the course of 20 h poste...

journal_title：Toxicology letters

authors： Wisniewska-Knypl JM,Sokal JA,Klimczak J,Dajniak A,Bogdanikowa B

更新日期：1981-05-01 00:00:00

abstract：:Several in vivo and in vitro studies have assessed methods of evaluating the cardio toxicity of compounds during drug development due to its importance for predicting human toxicity. However, in vivo/in vitro relationships have not yet been reported using a zebrafish model. This study determined the bradycardia of 15 ...

journal_title：Toxicology letters

authors： Park MJ,Lee KR,Shin DS,Chun HS,Kim CH,Ahn SH,Bae MA

更新日期：2013-01-10 00:00:00

abstract：:Enzymatic activities of Na+/K+-ATPase and Mg2+ -ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to prevent and recover the CuSO4-induced inhibition. The influence of experimentally added CuSO4 and E...

journal_title：Toxicology letters

authors： Vasić V,Jovanović D,Krstić D,Nikezić G,Horvat A,Vujisić L,Nedeljković N

更新日期：1999-10-29 00:00:00

abstract：:The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...

journal_title：Toxicology letters

authors： Watanabe M

更新日期：1998-12-28 00:00:00

abstract：:Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 microm and particularly the fine fraction (PM-2.5) smaller than 2.5 microm are responsible for adverse health effects, causing an increasing morbidity and mortality. Fu...

journal_title：Toxicology letters

authors： Hornberg C,Maciuleviciute L,Seemayer NH,Kainka E

更新日期：1998-08-01 00:00:00

abstract：:Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990s. In this study, we examined the effect of organoph...

journal_title：Toxicology letters

authors： Hirosawa N,Ueyama J,Kondo T,Kamijima M,Takagi K,Fujinaka S,Hirate A,Hasegawa T,Wakusawa S

更新日期：2011-05-30 00:00:00

abstract：:Actinomycin D (ActD) is a well-known cytotoxic chemotherapeutic reagent and the prevention of ActD-induced apoptotic cell death has been an attractive issue for biomedical investigators. Since phosphatidylinositol-3 kinase (PI3K)/Akt pathway is essential for cell survival, the present study has examined whether the pr...

journal_title：Toxicology letters

authors： Li W,Cai S,Cai L,Li X

更新日期：2006-08-20 00:00:00

abstract：:The toxicity of benz (e) acephenanthrylene (BeA) has been studied earlier with regard to the carcinogenicity of its metabolites, but its phototogenotoxicity is not well understood. Present study aimed to analyze the photodynamic response of BeA in human skin cell line (A375) under ambient environmental intensity of UV...

journal_title：Toxicology letters

authors： Ali D,Ray RS,Hans RK

更新日期：2010-11-30 00:00:00

abstract：:Early life exposure to certain kinds of chemicals is of concern because of a possible increase in cancer risk, but relevant data are limited. In the present experiment, modifying effects of prepubertal administration of potassium perchlorate (KClO(4)) and tetrabromobisphenol A (TBBPA) on susceptibility to multi-organ ...

journal_title：Toxicology letters

authors： Imai T,Takami S,Cho YM,Hirose M,Nishikawa A

更新日期：2009-03-28 00:00:00

abstract：:Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative biochemical, pathologic and...

journal_title：Toxicology letters

authors： Carter JH,Carter HW,DeAngelo AB

更新日期：1995-11-01 00:00:00

abstract：:1. The oocyte of the African clawed toad (Xenopus laevis) offers a reliable, sensitive and disease resistant system to investigate recombinantly and endogenously expressed Ca2+ signaling G protein-coupled receptors and their intracellular signaling pathways. 2. To study receptor induced Ca2+ release, two-electrode vol...

journal_title：Toxicology letters

authors： Nietgen GW,Hönemann CW,Durieux ME

更新日期：1998-11-23 00:00:00

abstract：:1,2-Dioxetanes, very reactive and high energy molecules, are involved as labile intermediates in dioxygenase-activated aerobic metabolism and in physiological processes. Various toxicological tests reveal that dioxetanes are indeed genotoxic. In supercoiled DNA of bacteriophage PM2 they induce endonuclease-sensitive s...

journal_title：Toxicology letters

authors： Adam W,Ahrweiler M,Saha-Möller CR,Sauter M,Schönberger A,Epe B,Müller E,Schiffmann D,Stopper H,Wild D

更新日期：1993-04-01 00:00:00

abstract：:New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify...

journal_title：Toxicology letters

authors： Richter LHJ,Beck A,Flockerzi V,Maurer HH,Meyer MR

更新日期：2019-02-01 00:00:00