Abstract:
:Tetrachlorobenzyltoluene (TCBT) (Ugilec 141) was investigated in induction experiments in male and female Wistar rats with long-term (50, 100 and 300 mg/kg p.o. daily for 28 days) and short-term administration (300 mg/kg once and 100 mg/kg daily for 4 days). The increase in total cytochrome P-450 did not exceed the factor of 1.9 compared to controls, while benzphetamine N-demethylase rose up to 3.5-fold the levels measured in controls, with very low induction of benzo(a)pyrene hydroxylase or ethoxyresorufin O-deethylase. Parallel investigations of UDP-glucuronosyltransferase showed induction of testosterone glucuronidation (1.7-fold). Administration (300 mg/kg body wt. once) of a pyrolysate of TCBT resulted in a marked increase in cytochrome P-450c dependent reactions (benzo(a)pyrene hydroxylase, ethoxyresorufin O-deethylase).
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
von Meyerinck L,Hufnagel B,Schmoldt A,Benthe HFdoi
10.1016/0378-4274(90)90208-4subject
Has Abstractpub_date
1990-04-01 00:00:00pages
163-74issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(90)90208-4journal_volume
51pub_type
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2003.10.015
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pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.04.004
更新日期:2010-07-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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journal_title:Toxicology letters
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pub_type: 杂志文章
doi:10.1016/j.toxlet.2003.12.053
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pub_type: 杂志文章
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更新日期:2014-04-07 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.06.023
更新日期:2014-12-01 00:00:00