Effect of diet on colonic-programmed cell death: molecular mechanism of action.

abstract：:Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits...

journal_title：Toxicology letters

authors： Nagl V,Woechtl B,Schwartz-Zimmermann HE,Hennig-Pauka I,Moll WD,Adam G,Berthiller F

更新日期：2014-08-17 00:00:00

abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

journal_title：Toxicology letters

authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

更新日期：2017-08-05 00:00:00

abstract：:(1) The hypothesis that inhalational anesthetics affect G-protein linked alpha2 adrenergic signaling pathway was investigated using human platelets as a model system. (2) Alpha2 receptor stimulation by UK-14304, a potent and selective agonist, inhibits cAMP production induced by prostaglandin I2 (PGI2). (3) Brief stim...

journal_title：Toxicology letters

authors： Pentyala S,Moller D,Chowdhury A,Sung KY,Rebecchi M

更新日期：1998-11-23 00:00:00

abstract：:Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

journal_title：Toxicology letters

authors： Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

更新日期：2018-10-15 00:00:00

abstract：:The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. H...

journal_title：Toxicology letters

authors： Nandan SD,Rao MS

更新日期：1982-11-01 00:00:00

abstract：:This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP). Horseradish peroxidase was employed as a positive control. GSH depletion or an increase in the absorption at 327 nm with time due to GS-PAP formation w...

journal_title：Toxicology letters

authors： Yang X,Kulkarni AP

更新日期：2000-01-05 00:00:00

abstract：:The tissue redistribution of accumulated 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in adult male A/J mice using a common human virus coxsackievirus B3. Before infection (day 1), all mice were injected intraperitoneally (i.p.) with 1 microCi 3H-TCDD, corresponding to 0.5 microg TCDD kg(-1...

journal_title：Toxicology letters

authors： Funseth E,Wicklund-Glynn A,Friman G,Ilbäck N

更新日期：2000-07-27 00:00:00

abstract：:The brominated flame retardant (BFR) hexabromocyclododecane was tested in a one-generation reproduction assay in Wistar rats, enhanced for endocrine parameters. A solution of the compound in corn oil was mixed in the feed, targeting at dietary exposure of 0-0.1-0.3-1-3-10-30-100 mg/kg body weight/day (mkd) in parental...

journal_title：Toxicology letters

authors： van der Ven LT,van de Kuil T,Leonards PE,Slob W,Lilienthal H,Litens S,Herlin M,Håkansson H,Cantón RF,van den Berg M,Visser TJ,van Loveren H,Vos JG,Piersma AH

更新日期：2009-02-25 00:00:00

abstract：:The proceedings in this volume suggest several important future research needs. Research is needed to validate modeling in toxicology in order to support the use of the general approach of modeling, either for structure-activity relationships (SAR) or physiologically based pharmacokinetics (PBPK), by regulators. Resea...

journal_title：Toxicology letters

authors： Menzel DB

更新日期：1995-09-01 00:00:00

abstract：:Exposition to cadmium (Cd) has been linked to bone metabolism alterations and occurrence of osteoporosis. Despite its known renal toxicity which indirectly disrupts bone metabolism through impairment of vitamin D synthesis, increasing evidence argues for the direct action of Cd on bone-forming osteoblasts. Indeed, acc...

journal_title：Toxicology letters

authors： Lizotte J,Abed E,Signor C,Malu DT,Cuevas J,Kevorkova O,Sanchez-Dardon J,Satoskar A,Scorza T,Jumarie C,Moreau R

更新日期：2012-12-17 00:00:00

abstract：:Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strate...

journal_title：Toxicology letters

authors： Ferraguti G,Ciolli P,Carito V,Battagliese G,Mancinelli R,Ciafrè S,Tirassa P,Ciccarelli R,Cipriani A,Messina MP,Fiore M,Ceccanti M

更新日期：2017-06-05 00:00:00

abstract：:Nano-materials are currently being used in a variety of fields. One of the concerns associated with their use is their potential to harm human health. In an attempt to identify genes expressed differently in human lung cells (WI-26 VA4) exposed to nanosized (45 nm in diameter) PAMAM (polyamidoamine) dendrimers, we obs...

journal_title：Toxicology letters

authors： Lee JH,Cha KE,Kim MS,Hong HW,Chung DJ,Ryu G,Myung H

更新日期：2009-10-28 00:00:00

abstract：:Octamethylcyclotetrasiloxane (D4) is a low-molecular-weight volatile cyclic siloxane, primarily used as an intermediate in the production of some widely-used industrial and consumer silicone based polymers and may be present as a component in a variety of consumer products. A global "harmonized" risk assessment was co...

journal_title：Toxicology letters

authors： Gentry R,Franzen A,Van Landingham C,Greene T,Plotzke K

更新日期：2017-10-20 00:00:00

abstract：:The in vitro N-methylating capability of rabbit tissue cytosolic preparations, utilizing S-adenosyl-L-[methyl-3H]methionine as methyl donor, is described. Dialysed preparations from the lung, liver and kidney are capable of N-methylating 3- and 4-phenylpyridines and 3,3'- and 4,4'-bispyridyls; the corresponding 2-subs...

journal_title：Toxicology letters

authors： Godin CS,Crooks PA,Damani LA

更新日期：1986-12-01 00:00:00

abstract：:N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...

journal_title：Toxicology letters

authors： Nogawa K,Yamada Y,Honda R,Tsuritani I,Ishizaki M,Sakamoto M

更新日期：1983-05-01 00:00:00

abstract：:Toxicogenomics describes the measurement of global gene expression changes in biological samples exposed to toxicants. This new technology promises to greatly facilitate research into toxicant mechanisms, with the possibility of assisting in the detection of compounds with the potential to cause adverse health effects...

journal_title：Toxicology letters

authors： Orphanides G

更新日期：2003-04-11 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

journal_title：Toxicology letters

authors： Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

更新日期：2014-08-04 00:00:00

abstract：:Acrolein, a potent cilioinhibitor of cigarette smoke was tested on synchronously dividing cultures. Mitosis could be blocked whenever the addition of acrolein was made during the cell cycle but this effect was totally reversible (between 0.06 microgram/ml to 1 microgram/ml). Nucleic acid syntheses were more affected t...

journal_title：Toxicology letters

authors： Marano F,Puiseux-Dao S

更新日期：1982-12-01 00:00:00

abstract：:The effect of endotoxin pretreatment (1 mg/kg body weight, i.p., once daily for 2 days) on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine has been studied in albino rats. When given alone, endotoxin did not produce any visibly discernible gastric lesions. It produced a significant augmenta...

journal_title：Toxicology letters

authors： Tariq M

更新日期：1987-06-01 00:00:00

abstract：:Blood lead concentrations (Pb-B, microgram/100 ml) was measured in children and adults, both sexes, living in and around Liège (control group, n = 859) and in the urban center of Verviers (exposed group, n = 568) where houses with lead piping are supplied with corrosive drinking water. In control children, the mean Pb...

journal_title：Toxicology letters

authors： Sartor FA,Rondia D

更新日期：1981-01-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism b...

journal_title：Toxicology letters

authors： Han M,Liu X,Liu S,Su G,Fan X,Chen J,Yuan Q,Xu G

更新日期：2017-05-05 00:00:00

abstract：:Rats injected i.p. with 100 mg ethylhexyl nitrate/kg body wt excreted 0.3% of the dose in the urine within 24 h. No urinary nitrite was found within 5 postinjection hours while an output of 26.9 +/- 15.8 micrograms nitrite/h X kg body wt. was detected between 5-24 h. Cerebral glutathione concentration was below the co...

journal_title：Toxicology letters

authors： Someroja S,Savolainen H

更新日期：1983-10-01 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:This study was initiated to identify a marker of choice to monitor occupational exposure to toluene through quantitative evaluation of changes in correlation coefficients (CCs), taking advantage of a large database. Six known or proposed exposure markers in end-of-shift blood (B) and urine (U) were studied, i.e., tolu...

journal_title：Toxicology letters

authors： Ikeda M,Ukai H,Kawai T,Inoue O,Maejima Y,Fukui Y,Ohashi F,Okamoto S,Takada S,Sakurai H

更新日期：2008-07-10 00:00:00

abstract：:A short-term initiation/promotion bioassay has been developed in rat liver using putative preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two protocols of the bioassay used in this study were varied according to the time 2/3 partial hepatectomy was performed in relation to when the in...

journal_title：Toxicology letters

authors： Herren SL,Pereira MA,Britt AL,Khoury MK

更新日期：1982-07-01 00:00:00

abstract：:In male Sprague-Dawley rats, motor and sensory conduction velocities (MNCV and SNCV) of the tail nerve decreased significantly as a result of oral administration of 400 and 200 mg/kg of 2,5 hexanedione (2,5-HD) once daily, 5 days a week for up to 7 and 15 weeks, respectively; and of whole-body exposure to 300 ppm of v...

journal_title：Toxicology letters

authors： Gagnaire F,Nicot T,Zissu D,Bonnet P,de Ceaurriz J

更新日期：1986-01-01 00:00:00

abstract：:Pregnant sows were fed a control diet (CON, 0.15 mg deoxynivalenol (DON) and 0.0035 mg zearalenone (ZON) per kg diet) or diet containing 15% of Fusarium toxin contaminated triticale (MYCO, 4.42 mg DON and 0.048 mg ZON per kg diet) during days 35-70 of gestation. All sows were fed in a restricted feeding regimen with t...

journal_title：Toxicology letters

authors： Tiemann U,Brüssow KP,Dannenberger D,Jonas L,Pöhland R,Jäger K,Dänicke S,Hagemann E

更新日期：2008-07-10 00:00:00

abstract：:A group of 20 female albino rats was exposed to mosquito coil smoke, 8 h a day, 6 days per week, for 60 days. An additional group receiving air exposure served as control. The smoke-exposed animals had a lower body weight than the controls. Smoke-induced histopathological lesions, including an inflammation of the trac...

journal_title：Toxicology letters

authors： Liu WK,Wong MH

更新日期：1987-12-01 00:00:00

abstract：:Trihalomethanes (THMs; chloroform, bromoform, bromodichloromethane, dibromochloromethane), formed as by-products of chlorine disinfection, are found to occur in combination in drinking water supplies. THMs are metabolized by cytochromes P-450 and are likely substrates of CYP2E1. Therefore, it is possible that mixed ex...

journal_title：Toxicology letters

authors： Luciene da Silva M,Charest-Tardif G,Krishnan K,Tardif R

更新日期：1999-05-20 00:00:00

abstract：:An in vivo intestinal perfusion technique was used to measure the absorption rates of five Cr compounds in black ducks. Cr was absorbed from saline solutions of KCr(SO4)2 and CrO3 at a rate about 1.5 to 2.0 times greater than from solutions of Cr, Cr(NO3)3, and Cr(C5H7O2)3. These results suggest the ionic form of Cr i...

journal_title：Toxicology letters

authors： Eastin WC Jr,Haseltine SD,Murray HC

更新日期：1980-08-01 00:00:00