当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs.

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs.

Abstract：

:Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits established for DON so far. The aim of our study was to contribute to the risk assessment of D3G by determination of its metabolism in pigs. Four piglets received water, D3G (116 μg/kg b.w.) and the equimolar amount of DON (75 μg/kg b.w.) by gavage on day 1, 5 and 9 of the experiment, respectively. Additionally, 15.5 μg D3G/kg b.w. were administered intravenously on day 13. Urine and feces were collected for 24 h and analyzed for DON, D3G, deoxynivalenol-3-glucuronide (DON-3-GlcA), deoxynivalenol-15-GlcA (DON-15-GlcA) and deepoxy-deoxynivalenol (DOM-1) by UHPLC-MS/MS. After oral application of DON and D3G, in total 84.8±9.7% and 40.3±8.5% of the given dose were detected in urine, respectively. The majority of orally administered D3G was excreted in form of DON, DON-15-GlcA, DOM-1 and DON-3-GlcA, while urinary D3G accounted for only 2.6±1.4%. In feces, just trace amounts of metabolites were found. Intravenously administered D3G was almost exclusively excreted in unmetabolized form via urine. Data indicate that D3G is nearly completely hydrolyzed in the intestinal tract of pigs, while the toxin seems to be rather stable after systemic absorption. Compared to DON, the oral bioavailability of D3G and its metabolites seems to be reduced by a factor of up to 2, approximately.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Nagl V,Woechtl B,Schwartz-Zimmermann HE,Hennig-Pauka I,Moll WD,Adam G,Berthiller F

doi

10.1016/j.toxlet.2014.06.032

subject

Has Abstract

pub_date

2014-08-17 00:00:00

pages

190-7

issue

1

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(14)00282-3

journal_volume

229

pub_type

杂志文章

相关文献

TOXICOLOGY LETTERS文献大全
  • Synergistic effects of peroxynitrite on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts.

    abstract：:Epidemiological studies have demonstrated a clear association between betel nut chewing and an increased risk for oral mucosal lesions. Arecoline, the most abundant betel alkaloid, is considered the most important etiologic factor in betel nuts. In addition, most betel nut chewers are also smokers. In order to elucida...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(00)00262-9

    authors： Chang YC,Tai KW,Chou MY,Tseng TH

    更新日期：2000-12-20 00:00:00

  • Influx of extracellular calcium participates in rituximab-enhanced ionizing radiation-induced apoptosis in Raji cells.

    abstract：:We have previously shown that rituximab has a significant radiosensitizing effect on Raji cells in vitro. To investigate whether calcium signals participate in rituximab- and radiation-induced cell death in Raji cells, confocal laser scanning microscopy was used to detect kinetic changes in intracellular free calcium ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2011.12.018

    authors： Fengling M,Qingxiang G,Lijia Z,Wei Z

    更新日期：2012-03-25 00:00:00

  • Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha.

    abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) and aryl hydrocarbon receptor (AhR) both require dimerization with AhR nuclear translocator (ARNT) to initiate transcription of their respective target genes. It has been proposed that competition for ARNT results in decreased targeting of AhR to cytochrome P450 1A1 (CYP1A1...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2004.09.006

    authors： Allen JW,Johnson RS,Bhatia SN

    更新日期：2005-01-15 00:00:00

  • Effects of cyanobacteria Oscillatoria sp. lipopolysaccharide on B cell activation and Toll-like receptor 4 signaling.

    abstract：:Cyanobacteria ("blue-green algae"), such as Oscillatoria sp., are a ubiquitous group of bacteria found in freshwater systems worldwide that are linked to illness and in some cases, death among humans and animals. Exposure to cyanobacteria occurs via ingestion of contaminated water or food-products. Exposure of the gut...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2017.05.013

    authors： Swanson-Mungerson M,Incrocci R,Subramaniam V,Williams P,Hall ML,Mayer AMS

    更新日期：2017-06-05 00:00:00

  • Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways.

    abstract：:Arsenic (As), a ubiquitous toxic metal, is an important environmental and industrial pollutant throughout the world. Inorganic As (iAs) is usually more harmful than organic ones and with a high risk of diabetes incidence by exposure. However, the toxicological effects of iAs on growth and function of pancreatic β-cell...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2010.11.019

    authors： Lu TH,Su CC,Chen YW,Yang CY,Wu CC,Hung DZ,Chen CH,Cheng PW,Liu SH,Huang CF

    更新日期：2011-02-25 00:00:00

  • Measuring problems in estimating the exposure to passive smoking using the excretion of cotinine.

    abstract：:Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(87)90083-x

    authors： Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

    更新日期：1987-01-01 00:00:00

  • Repeated exposure of C57Bl mice to inhaled benzene at 10 ppm markedly depressed erythropoietic colony formation.

    abstract：:Exposure of C57Bl mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(84)90169-3

    authors： Baarson KA,Snyder CA,Albert RE

    更新日期：1984-03-01 00:00:00

  • Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-κB activation and HSP70 up-regulation.

    abstract：:Chemotherapy resistance represents a major problem for the treatment of patients with lung carcinomas. Parthenolide (PN), a naturally occurring small molecule found in herb feverfew, has been used in clinical treatment. Although its importance in treating the chemotherapy resistance has been shown, the pharmacological...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2013.06.215

    authors： Xin Y,Yin F,Qi S,Shen L,Xu Y,Luo L,Lan L,Yin Z

    更新日期：2013-08-14 00:00:00

  • Urinary excretion of heptanones, heptanoles and 2,5-heptanedione after controlled acute exposure of volunteers to n-heptane.

    abstract：:A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, we collected information on urinary n-heptane metabolite concentrations and the time course of metabolite excretion. Relationships between external and internal ex...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2018.03.031

    authors： Rossbach B,Kegel P,Letzel S

    更新日期：2018-12-01 00:00:00

  • Correlation of liver tumor morphology and weight to incidence of pulmonary metastases in the mouse.

    abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(80)90042-9

    authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

    更新日期：1980-12-01 00:00:00

  • Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats.

    abstract：:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(98)00035-6

    authors： Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

    更新日期：1998-05-01 00:00:00

  • Chlordecone potentiates auto-immune hepatitis and promotes brain entry of MHV3 during viral hepatitis in mouse models.

    abstract：:Chlordecone is an organochlorine used in the 1970's as a pesticide in banana plantations. It has a long half-life in the soil and can potentially contaminate humans and animals through food. Chlordecone targets, and mainly accumulates in, the liver, leading to hepatomegaly and neurological signs in mammals. Chlordecon...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2018.09.014

    authors： Tabet E,Gelu-Simeon M,Genet V,Lamontagne L,Piquet-Pellorce C,Samson M

    更新日期：2018-12-15 00:00:00

  • Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.

    abstract：:The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effect of the OP Crotylsarin (CRS) on respir...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2011.07.005

    authors： Klein-Rodewald T,Seeger T,Dutschmann M,Worek F,Mörschel M

    更新日期：2011-09-25 00:00:00

  • Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

    abstract：:In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2019.09.014

    authors： Gohlsch K,Mückter H,Steinritz D,Aufderheide M,Hoffmann S,Gudermann T,Breit A

    更新日期：2019-11-01 00:00:00

  • In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes.

    abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplace...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.04.004

    authors： Crowell SR,Hanson-Drury S,Williams DE,Corley RA

    更新日期：2014-07-03 00:00:00

  • The protective effects of glutathione against methylmercury cytotoxicity.

    abstract：:Mouse neuroblastoma cells exposed to 2.5 and 5.0 microM methylmercury for 24 h appeared rounded with the loss of processes. Immunohistochemical staining directed against beta-tubulin revealed severe alterations in microtubular architecture. Non-membrane-bound condensation product was visualized ultrastructurally in th...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(90)90226-c

    authors： Kromidas L,Trombetta LD,Jamall IS

    更新日期：1990-03-01 00:00:00

  • Inter- and intra-individual variation in urinary biomarker concentrations over a 6-day sampling period. Part 1: metals.

    abstract：:The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individu...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.08.014

    authors： Smolders R,Koch HM,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R,Hays SM,Aylward LL

    更新日期：2014-12-01 00:00:00

  • Ethanolamine stimulates repair processes in acute CCl4 damage of mouse liver.

    abstract：:Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(97)00112-4

    authors： Murakami T,Nagamura Y,Hirano K

    更新日期：1998-01-31 00:00:00

  • Potential mechanisms of tumorigenic action of diethanolamine in mice.

    abstract：:Diethanolamine (DEA), a secondary amine found in a number of consumer products, reportedly induces liver tumors in mice. In an attempt to define the tumorigenic mechanism of DEA, N-nitrosodiethanolamine (NDELA) formation in vivo and development of choline deficiency were examined in mice. DEA was administered with or ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(99)00197-6

    authors： Stott WT,Bartels MJ,Brzak KA,Mar M,Markham DA,Thornton CM,Zeisel SH

    更新日期：2000-04-03 00:00:00

  • Testicular toxicity following short-term exposure to tri- and hexavalent chromium: an experimental study in the rat.

    abstract：:The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(90)90069-x

    authors： Ernst E

    更新日期：1990-05-01 00:00:00

  • Assessment of effect levels of chemicals from quantitative structure-activity relationship (QSAR) models. I. Chronic lowest-observed-adverse-effect level (LOAEL).

    abstract：:With the multitude of new chemicals being synthesized and the paucity of long-term test data on chemicals that could be introduced into the environment, innovative approaches must be developed to determine the health and environmental effects of chemicals. Research was conducted to employ quantitative structure-activi...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(95)03365-r

    authors： Mumtaz MM,Knauf LA,Reisman DJ,Peirano WB,DeRosa CT,Gombar VK,Enslein K,Carter JR,Blake BW,Huque KI

    更新日期：1995-09-01 00:00:00

  • No increase in carcinogen-DNA adducts in the lungs of monkeys exposed chronically to marijuana smoke.

    abstract：:Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mea...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(92)90094-z

    authors： Talaska G,Schamer M,Bailey JR,Ali SF,Scallet AC,Slikker W Jr,Paule MG

    更新日期：1992-12-01 00:00:00

  • Strain differences in susceptibility to di-2-ethylhexyl phthalate-induced testicular atrophy in mice.

    abstract：:It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(93)90078-c

    authors： Oishi S

    更新日期：1993-01-01 00:00:00

  • Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway.

    abstract：:Chronic exposure to arsenic increases the risk of developing a variety of human cancers including lung carcinomas. However, the exact molecular mechanism underlying arsenic carcinogenicity remains largely unknown. Autophagy is a conserved catabolic process for maintaining cellular protein homeostasis whose defects mig...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2020.06.006

    authors： Wu L,Wang Z,Li X,He X,Han Y,Chen Y,Liu L,Fu L,Zhang T

    更新日期：2020-10-10 00:00:00

  • Urinary trehalase activity and renal brush-border damage in inhabitants of a cadmium-polluted area (Jinzu River basin).

    abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(86)90206-7

    authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

    更新日期：1986-12-01 00:00:00

  • Induction of renin release from isolated glomeruli by inorganic mercury(II).

    abstract：:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(96)03637-5

    authors： Kozma L,Lenkey A,Varga E,Gomba S

    更新日期：1996-04-01 00:00:00

  • Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells.

    abstract：:Mechanism of PAH mixtures, using granulosa tumour cells, was investigated. Cells were exposed to a mixture of all 16 priority PAHs (M1) or a mixture of five PAHs not classified as human carcinogens (M2). The effect of siAHR, siAHRR and siNFKB2 on the expression of CYP1A1, CYP1B1, GSTM1, ERα, AR and cell proliferation ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2019.04.008

    authors： Zajda K,Rak A,Ptak A,Gregoraszczuk EL

    更新日期：2019-08-01 00:00:00

  • No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats.

    abstract：:Several studies have demonstrated that bisphenol A (BPA) exhibited weak estrogenic activity in the 3-day uterotrophic assay using ovariectomized (OVX) and immature rats (Toxicol. Lett. 115 (2000) 231; Regul. Toxicol. Pharmacol. 32 (2000) 118; J. Toxicol. Sci. 26 (2001) 111) and BPA also possessed anti-androgenic activ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(02)00130-3

    authors： Kim HS,Han SY,Kim TS,Kwack SJ,Lee RD,Kim IY,Seok JH,Lee BM,Yoo SD,Park KL

    更新日期：2002-09-05 00:00:00

  • Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry.

    abstract：:This study aims to determine whether quercetin elicits a protective effect against the toxicity of chronic exposure to low-level DDVP using metabonomic technology. Rats were randomly assigned into the control, DDVP-treated, quercetin-treated, and quercetin plus DDVP-treated groups. DDVP and quercetin were given to rat...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2013.12.017

    authors： Wang H,Li S,Qi L,Xu W,Zeng Y,Hou Y,Zhao X,Sun C

    更新日期：2014-03-03 00:00:00

  • Immediate and delayed effects of subchronic Paraquat exposure during an early differentiation stage in 3D-rat brain cell cultures.

    abstract：:Xenobiotic exposure is a risk factor in the etiology of neurodegenerative disease. It was recently hypothesized that restricted exposure during brain development could predispose for a neurodegenerative disease later in life. As neuroinflammation contributes to progressive neurodegeneration, it is suspected that neuro...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.02.001

    authors： Sandström von Tobel J,Zoia D,Althaus J,Antinori P,Mermoud J,Pak HS,Scherl A,Monnet-Tschudi F

    更新日期：2014-10-15 00:00:00