Toxicogenomics: challenges and opportunities.

abstract：:Activation of the cold-receptor TRPM8 by menthol or other tobacco additives can suppress natural defense reactions such as coughing that usually would become effective as involuntary resistance against the inhalation of fumes. In Europe menthol is only regulated as flavor, but can be used as additive as long as no cha...

journal_title：Toxicology letters

authors： Paschke M,Tkachenko A,Ackermann K,Hutzler C,Henkler F,Luch A

更新日期：2017-04-05 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:The lithocholic acid-sensitive mutant cells were isolated from CHO-9 cells mutagenized with ethylmethane sulfonate, through clonal selection on 96-well dishes. The isolated mutant cells (LSJ-11) were 3-fold more sensitive than controls in the survival to lithocholic acid and were also sensitive to other bile acids suc...

journal_title：Toxicology letters

authors： Kaneko M,Kodama M,Inoue F,Horikoshi J

更新日期：1993-03-01 00:00:00

abstract：:Iodinated contrast media (CM) can induce apoptosis and necrosis of renal tubular cells. The injuries of endothelial cells induced by CM on the systemic condition have not been fully understood. To assess the toxic effects of non-ionic CM on the glomerular and aortic endothelial cells, iopromide and iodixanol, two kind...

journal_title：Toxicology letters

authors： Zhao Y,Tao Z,Xu Z,Tao Z,Chen B,Wang L,Li C,Chen L,Jia Q,Jia E,Zhu T,Yang Z

更新日期：2011-05-10 00:00:00

abstract：:Skin esterases serve an important pharmacological function as they can be utilised for activation of topically applied ester prodrugs. Understanding the nature of these enzymes, with respect to their role and local activity, is essential to defining the efficacy of ester prodrugs. Minipigs are used as models to study ...

journal_title：Toxicology letters

authors： Jewell C,Prusakiewicz JJ,Ackermann C,Payne NA,Fate G,Williams FM

更新日期：2007-09-10 00:00:00

abstract：:Troglitazone (Tro) is a thiazolidinedione antidiabetic drug that was withdrawn from the market due to its association with idiosyncratic severe liver injury. Tro has never induced liver injury in experimental animals in vivo. It was assumed that the species differences between human and experimental animals in the pha...

journal_title：Toxicology letters

authors： Kakuni M,Morita M,Matsuo K,Katoh Y,Nakajima M,Tateno C,Yokoi T

更新日期：2012-10-02 00:00:00

abstract：:Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

journal_title：Toxicology letters

authors： Hoffmann M,Fiedor E,Ptak A

更新日期：2017-03-05 00:00:00

abstract：:Exposure to phthalate esters during sexual differentiation disrupts testosterone and insulin-like three hormones resulting in malformations of androgen- and insulin-like three-dependent tissues. The current study was designed to test the hypothesis that gubernacular lesions would be more prevalent in the DEHP-treated ...

journal_title：Toxicology letters

authors： Wilson VS,Howdeshell KL,Lambright CS,Furr J,Earl Gray L Jr

更新日期：2007-05-15 00:00:00

abstract：:Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

journal_title：Toxicology letters

authors： Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

更新日期：2013-05-23 00:00:00

abstract：:Induction of endotoxin tolerance in rats led to reductions in bile flow and BSP excretion. BSP serum retention or storage of BSP in the liver was not affected. Although serum alanine aminotransferase (ALT) activity was slightly elevated in endotoxin-tolerant rats, the levels of serum aspartate amino-transferase (AST) ...

journal_title：Toxicology letters

authors： Boelsterli UA,Abernathy CO,Balazs T,Zimmerman HJ

更新日期：1982-05-01 00:00:00

abstract：:The tobacco smoking habit interferes with the innate host defence system against infections. Recurrent infections accelerated the functional respiratory decline. The present study assessed the effects of ceftaroline on TLR2 and TLR4 and on pro-inflammatory responses in airway epithelial cells (16HBE cell line and prim...

journal_title：Toxicology letters

authors： Pace E,Ferraro M,Di Vincenzo S,Siena L,Gjomarkaj M

更新日期：2016-09-06 00:00:00

abstract：:A toxicogenomics approach was applied to assess the usefulness of the mouse cytotoxic T cell line CTLL-2 for in vitro immunotoxicity testing. CTLL-2 cells were exposed for 6 h to two model immunotoxic compounds: (1) the mycotoxin deoxynivalenol (DON, 1 and 2 μM), a ribotoxic stress inducer, and (2) the organotin compo...

journal_title：Toxicology letters

authors： Schmeits PC,Volger OL,Zandvliet ET,van Loveren H,Peijnenburg AA,Hendriksen PJ

更新日期：2013-02-13 00:00:00

abstract：:Staphylococcal enterotoxin A (SEA) is a potent stimulator of CD4+ and CD8+ T cells, the immunotoxic action of which remains unclear. We investigated the in vitro effects of SEA on freshly isolated human peripheral blood lymphocytes depleted of CD8+ T cells. Proliferation and flow cytometry analysis indicated that SEA ...

journal_title：Toxicology letters

authors： Porichis F,Morou A,Baritaki S,Spandidos DA,Krambovitis E

更新日期：2008-01-04 00:00:00

abstract：:The transition metal cadmium (Cd) is an environmental pollutant which damages the kidneys. Chronic Cd exposure may induce renal fibrosis and/or cancer, but the signaling pathways involved are not understood. The Wnt pathway is a key signaling cascade responsible for renal development, fibrosis and cancer. Hence the ef...

journal_title：Toxicology letters

authors： Chakraborty PK,Scharner B,Jurasovic J,Messner B,Bernhard D,Thévenod F

更新日期：2010-09-15 00:00:00

abstract：:Epidemiological studies have demonstrated a clear association between betel nut chewing and an increased risk for oral mucosal lesions. Arecoline, the most abundant betel alkaloid, is considered the most important etiologic factor in betel nuts. In addition, most betel nut chewers are also smokers. In order to elucida...

journal_title：Toxicology letters

authors： Chang YC,Tai KW,Chou MY,Tseng TH

更新日期：2000-12-20 00:00:00

abstract：:Genomic DNA is under continuous assault by various chemical species produced by normal cellular metabolism. In addition, exposure to exogenous agents adds further insult. Modification of DNA by chemical carcinogens has long been recognized as an early event in carcinogenesis and many DNA adducts have been characterize...

journal_title：Toxicology letters

authors： Shuker DE

更新日期：2002-08-05 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...

journal_title：Toxicology letters

authors： Zhou J,Geng F,Xu J,Peng L,Ye X,Yang D,Zhao J,Sun Q

更新日期：2019-11-01 00:00:00

abstract：:Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was a...

journal_title：Toxicology letters

authors： Bhisey RA,Bagwe AN,Mahimkar MB,Buch SC

更新日期：1999-09-05 00:00:00

abstract：:Breathing pattern and lung mechanical parameters were measured in 7 female Wistar rats (ca. 200 g) during exposure to 1.0 (n = 5) or 1.3 (n = 2) ppm ozone in air for 2 h and during a 2-h post-exposure observation period. Changes in breathing pattern showed a gradual decrease from 3 to 2 Hz at constant minute ventilati...

journal_title：Toxicology letters

authors： Zwart A,Arts JH

更新日期：1994-06-01 00:00:00

abstract：:New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify...

journal_title：Toxicology letters

authors： Richter LHJ,Beck A,Flockerzi V,Maurer HH,Meyer MR

更新日期：2019-02-01 00:00:00

abstract：:The exposure to cuprizone (CPZ) leads to demyelination in the central nervous system in rodents. To examine the developmental effects of CPZ exposure on hippocampal neurogenesis, pregnant rats were treated with 0, 0.1 or 0.4% CPZ in the diet from gestational day 6 to day 21 after delivery. On postnatal day 21, male of...

journal_title：Toxicology letters

authors： Abe H,Tanaka T,Kimura M,Mizukami S,Imatanaka N,Akahori Y,Yoshida T,Shibutani M

更新日期：2015-05-05 00:00:00

abstract：:To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most imp...

journal_title：Toxicology letters

authors： Rappaport SM,Li H,Grigoryan H,Funk WE,Williams ER

更新日期：2012-08-13 00:00:00

abstract：:Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 microm and particularly the fine fraction (PM-2.5) smaller than 2.5 microm are responsible for adverse health effects, causing an increasing morbidity and mortality. Fu...

journal_title：Toxicology letters

authors： Hornberg C,Maciuleviciute L,Seemayer NH,Kainka E

更新日期：1998-08-01 00:00:00

abstract：:288 BALB/c male mice were allocated to: Group 1-control; Group 2-500 ppm of 2-acetylaminofluorene (2-AAF) in the food, with control water; Group 4-500 ppm of 2-AAF in the food and 250 mg/100 ml of vitamin C in the water; and Group 3-control food and 250 mg% of vitamin C in the water. Major histopathologic changes at t...

journal_title：Toxicology letters

authors： Frith CH,Rule J,Kodell RL

更新日期：1980-09-01 00:00:00

abstract：:Epidemiological investigations indicate that effects related to prenatal adverse environments on the organs of the offspring could continue to adulthood. This study intends to confirm that prenatal nicotine exposure (PNE) increases the susceptibility of osteoarthritis (OA) in the male offspring, and to explore the pot...

journal_title：Toxicology letters

authors： Chen B,Lu KH,Ni QB,Li QX,Gao H,Wang H,Chen LB

更新日期：2019-10-10 00:00:00

abstract：:The effect of a single intravenous (i.v.) injection of cadmium nitrate was investigated in livers of male Wistar rats. A significant increase in liver weight, accompanied by an elevation of total hepatic DNA content was observed. DNA synthesis as measured by the incorporation of [3H]thymidine, was found to be 6 times ...

journal_title：Toxicology letters

authors： Ledda-Columbano GM,Columbano A,Coni PP,Vargiu M,Liguori C,Pani P

更新日期：1984-12-01 00:00:00

abstract：:Pyrethroid pesticides are used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegradibility. However, it is possible that during the pyrethroid metabolism, there is generation of reactive oxygen species (ROS) and pyrethroids may pr...

journal_title：Toxicology letters

authors： Kale M,Rathore N,John S,Bhatnagar D

更新日期：1999-04-12 00:00:00

abstract：:Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-Dawley (SD) rats were used to establish animal models...

journal_title：Toxicology letters

authors： Cao XN,Shen LJ,Wu SD,Yan C,Zhou Y,Xiong G,Wang YC,Liu Y,Liu B,Tang XL,Guo M,Liu DY,Long CL,Sun M,He DW,Lin T,Wei GH

更新日期：2017-01-15 00:00:00

abstract：:Samples of PM(2.5) were gravimetrically collected during the winter 2005/2006 in the urban area of Milan (North Italy). Samples were chemically characterized and the particles were detached from filters to determine their cytotoxic effects on the A549 cell line. Based on the potential toxicological relevance of its co...

journal_title：Toxicology letters

authors： Gualtieri M,Mantecca P,Corvaja V,Longhin E,Perrone MG,Bolzacchini E,Camatini M

更新日期：2009-07-10 00:00:00