Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species.

abstract：:When pregnant mice were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the average time to eye opening in the offspring was shortened by about a day. How acceleration of eye opening by TCDD occurs remains unknown. To reveal the underlying mechanisms of the accelerated eye opening, pregnant mice were intraperit...

journal_title：Toxicology letters

authors： Gin DW,Kim HR,Lee DM,Lee SH,Seong AR,Hwang JA,Park JH

更新日期：2010-07-01 00:00:00

abstract：:Pregnant rats were exposed to 0, 100, 200, 400 or 800 ppm of carbon disulfide (CS2), 100 ppm of hydrogen sulfide (H2S) alone or in combination with 400 and 800 ppm CS2, 6 h/d during days 6-20 of gestation. Maternal reproduction and fetal parameters were evaluated on gestational day 21. Treatment with 100 or 200 ppm CS...

journal_title：Toxicology letters

authors： Saillenfait AM,Bonnet P,de Ceaurriz J

更新日期：1989-07-01 00:00:00

abstract：:PFAS are man-made compounds that are highly spread in the environment. Human dietary exposure to such contaminants is of high concern as they may accumulate in the food chain. Different studies already demonstrated the importance of the fish consumption in the dietary exposure of these molecules and the potential incr...

journal_title：Toxicology letters

authors： Denys S,Fraize-Frontier S,Moussa O,Le Bizec B,Veyrand B,Volatier JL

更新日期：2014-12-01 00:00:00

abstract：:Dopaminergic system dysfunction is proved to be a possible mechanism in acrylamide (ACR) -induced neurotoxicity. The neurotransmitter dopamine (DA) has an increasingly important role in the dopaminergic system. Thus, the goal of this study is to evaluate effects of ACR on dopamine and its metabolite levels, dopamine t...

journal_title：Toxicology letters

authors： Pan X,Guo X,Xiong F,Cheng G,Lu Q,Yan H

更新日期：2015-07-02 00:00:00

abstract：:Cellular uptake and cytotoxicity of chenodeoxycholic acid, delivered free or encapsulated in liposomes, were compared in isolated rat hepatocytes. As quantified by leakage of cytoplasmic and lysosomal enzymes into the medium, cells exposed to free chenodeoxycholic acid displayed a dose-dependent cytotoxic response. Ce...

journal_title：Toxicology letters

authors： Salhab AS,Stacey NH,Dujovne CA

更新日期：1984-04-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplace...

journal_title：Toxicology letters

authors： Crowell SR,Hanson-Drury S,Williams DE,Corley RA

更新日期：2014-07-03 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a proven animal carcinogen. Occupational cohorts with the highest exposures imply that there is a small risk of all cancers combined, but it is difficult to pinpoint the confounding effect of the main chemicals. Studies after major accidents do not unequivocally confirm th...

journal_title：Toxicology letters

authors： Tuomisto J,Tuomisto JT

更新日期：2012-05-05 00:00:00

abstract：:Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing...

journal_title：Toxicology letters

authors： Chung WG,Yu IJ,Park CS,Lee KH,Roh HK,Cha YN

更新日期：1999-01-11 00:00:00

abstract：:The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...

journal_title：Toxicology letters

authors： Venkata NG,Robinson JA,Cabot PJ,Davis B,Monteith GR,Roberts-Thomson SJ

更新日期：2006-06-01 00:00:00

abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

journal_title：Toxicology letters

authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

更新日期：2012-10-17 00:00:00

abstract：:The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effect of the OP Crotylsarin (CRS) on respir...

journal_title：Toxicology letters

authors： Klein-Rodewald T,Seeger T,Dutschmann M,Worek F,Mörschel M

更新日期：2011-09-25 00:00:00

abstract：:With the multitude of new chemicals being synthesized and the paucity of long-term test data on chemicals that could be introduced into the environment, innovative approaches must be developed to determine the health and environmental effects of chemicals. Research was conducted to employ quantitative structure-activi...

journal_title：Toxicology letters

authors： Mumtaz MM,Knauf LA,Reisman DJ,Peirano WB,DeRosa CT,Gombar VK,Enslein K,Carter JR,Blake BW,Huque KI

更新日期：1995-09-01 00:00:00

abstract：:The effects of 3 weeks' or 6 months' inhalation exposure of rats to aromatic white spirit 6 h/day, 5 days/week at 0, 400, or 800 ppm were studied. Synaptosomal neurochemistry was investigated as index of the in situ conditions in the presynaptic nerve terminal. In both studies, the relative and absolute yield of synap...

journal_title：Toxicology letters

authors： Lam HR,Ostergaard G,Ladefoged O

更新日期：1995-10-01 00:00:00

abstract：:The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...

journal_title：Toxicology letters

authors： Yamada YK,Shimizu F,Kawamura R,Kubota K

更新日期：1981-04-01 00:00:00

abstract：:Uncertainty in risk assessment can be reduced by increasing the use of relevant data specific to the particular xenobiotic and exposed organism. We describe the development of a preliminary, mechanism-based exposure response model for chloroform hepatotoxicity consistig of toxicokinetic (TK) and toxicodynamic (TD) sub...

journal_title：Toxicology letters

authors： Conolly RB,Butterworth BE

更新日期：1995-12-01 00:00:00

abstract：:Previous studies have suggested that elevated blood homocysteic acid (HCA) levels increased the risk of Alzheimer's disease (AD), but the underlying mechanisms are unclear. Herein, we studied the neuronal toxicity of HCA and the underlying mechanisms in HT-22 cells. Results showed that HCA induced cell death in concen...

journal_title：Toxicology letters

authors： Tan M,Ouyang Y,Jin M,Chen M,Liu P,Chao X,Chen Z,Chen X,Ramassamy C,Gao Y,Pi R

更新日期：2013-10-23 00:00:00

abstract：:The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment of Reproductive Toxicity data indicated the Agency's intention for wide use of the technique. In developmental toxicity experiments, a number of factors need t...

journal_title：Toxicology letters

authors： Foster PM,Auton TR

更新日期：1995-12-01 00:00:00

abstract：:Exposure to cyanide from gari, a popular cassava food in West Africa, is implicated in the causation of ataxic polyneuropathy and amblyopia, but this has been questioned because cyanide was not detected in gari in a study. This study was carried out to determine if gari is a source of exposure to cyanide. Gari (150 g)...

journal_title：Toxicology letters

authors： Oluwole OS,Onabolu AO,Sowunmi A

更新日期：2002-09-05 00:00:00

abstract：:Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 microm and particularly the fine fraction (PM-2.5) smaller than 2.5 microm are responsible for adverse health effects, causing an increasing morbidity and mortality. Fu...

journal_title：Toxicology letters

authors： Hornberg C,Maciuleviciute L,Seemayer NH,Kainka E

更新日期：1998-08-01 00:00:00

abstract：:Synthetic musks are present in fine fragrances, cosmetics, soaps and laundry detergents. One of the most important synthetic musks is 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydro-naphthaline+ ++ (AHTN; annual production: about 1500 metric tons). An increasing number of studies show that AHTN accumulates in surfa...

journal_title：Toxicology letters

authors： Steinberg P,Fischer T,Arand M,Park E,Elmadfa I,Rimkus G,Brunn H,Dienes HP

更新日期：1999-12-20 00:00:00

abstract：:Intraperitoneal (i.p.) and intravenous (i.v.) injection of 44Ti in a chloride solution into mice produced no detectable translocation in body fluids. There was no obvious interorgan exchange up to 16 days after injection. The whole body biological retention half-lives had a mean of 642 days for both routes, another in...

journal_title：Toxicology letters

authors： Thomas RG,Archuleta RF

更新日期：1980-07-01 00:00:00

abstract：:About two decades ago in vitro mutagenicity tests were adopted as the first in vitro methods in regulatory toxicology. For reasons of animal welfare and better science, many validation studies of various in vitro methods were performed between 1985 and 1995 for their potential to replace the Draize eye irritation test...

journal_title：Toxicology letters

authors： Liebsch M,Spielmann H

更新日期：2002-02-28 00:00:00

abstract：:Samples of PM(2.5) were gravimetrically collected during the winter 2005/2006 in the urban area of Milan (North Italy). Samples were chemically characterized and the particles were detached from filters to determine their cytotoxic effects on the A549 cell line. Based on the potential toxicological relevance of its co...

journal_title：Toxicology letters

authors： Gualtieri M,Mantecca P,Corvaja V,Longhin E,Perrone MG,Bolzacchini E,Camatini M

更新日期：2009-07-10 00:00:00

abstract：:Skin esterases serve an important pharmacological function as they can be utilised for activation of topically applied ester prodrugs. Understanding the nature of these enzymes, with respect to their role and local activity, is essential to defining the efficacy of ester prodrugs. Minipigs are used as models to study ...

journal_title：Toxicology letters

authors： Jewell C,Prusakiewicz JJ,Ackermann C,Payne NA,Fate G,Williams FM

更新日期：2007-09-10 00:00:00

abstract：:Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...

journal_title：Toxicology letters

authors： Ahluwalia P,Malik VB

更新日期：1989-02-01 00:00:00

abstract：:Effect of chrysotile dust alone or together with Candida albicans administered intratracheally in guinea pigs was studied in the genesis of pleural plaques over a period of 12 months. A significant increase of mucopolysaccharides, phosphorus, calcium and -SH content was detected in pleural fluid of animals treated wit...

journal_title：Toxicology letters

authors： Saxena KC,Srivastava L,Ali S,Dogra RK

更新日期：1982-10-01 00:00:00

abstract：:We investigated the effect of copper on cadmium-induced cytotoxicity on vascular endothelial cells from bovine aorta in a culture system. Cytotoxicity was evaluated by the [3H]adenine release assay and the histological observation. After a 24-h incubation, cadmium exhibited a significant cytotoxicity on confluent cult...

journal_title：Toxicology letters

authors： Kaji T,Fujiwara Y,Koyanagi E,Yamamoto C,Mishima A,Sakamoto M,Kozuka H

更新日期：1992-10-01 00:00:00

abstract：:Male Sprague-Dawley rats were treated i.p. with different doses of bromobenzene (0, 0.1, 0.2, 0.3 and 0.5 mmol/kg) in corn oil for 4 weeks. The animals were killed 24 h after the end of the treatment for hepatic drug metabolism studies. A significant induction of the activities of microsomal aniline hydroxylase (51%) ...

journal_title：Toxicology letters

authors： Chakrabarti S

更新日期：1984-01-01 00:00:00

abstract：:Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 40 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Treatment with the organic anion transport...

journal_title：Toxicology letters

authors： Ban M,de Céaurriz J

更新日期：1988-01-01 00:00:00

abstract：:Alternaria spp. are ubiquitous molds that are able to produce toxic secondary metabolites which may contaminate food globally. One of those is the mycotoxin altertoxin II (ATX-II), a genotoxic and mutagenic compound. In recent years, different flavonoids that may co-occur with mycotoxins in food were demonstrated to t...

journal_title：Toxicology letters

authors： Aichinger G,Puntscher H,Beisl J,Kütt ML,Warth B,Marko D

更新日期：2018-03-01 00:00:00