Protective effect of copper against cadmium cytotoxicity on cultured vascular endothelial cells.

abstract：:E-64d (a calpain and autophagy inhibitor) has previously been shown safe for the treatment of Alzheimer's disease in humans. In the present study, the potential protective mechanism of E-64d on hippocampal aberrant mossy fiber sprouting was examined in a developmental rat model of penicillin-induced recurrent epilepti...

journal_title：Toxicology letters

authors： Ni H,Ren SY,Zhang LL,Sun Q,Tian T,Feng X

更新日期：2013-02-27 00:00:00

abstract：:The effects of four phthalates, i.e., di-2-ethylhexyl phthalate (DEHP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP) and diisobutyl phthalate (DIBP) on necrotic and apoptotic cell death, and production of reactive oxygen species (ROS) were studied on mouse macrophage cell line RAW 264.7. All the phthalates ca...

journal_title：Toxicology letters

authors： Naarala J,Korpi A

更新日期：2009-07-24 00:00:00

abstract：:In connection with extensive health studies of employees from two big central waste disposal sites, cytogenetic investigations were performed. The subject of these special analyses was to examine whether the complex mixture of pollutants from waste disposal sites comprises a genotoxic hazardous potential. Cytogenetic ...

journal_title：Toxicology letters

authors： Fender H,Wolf G

更新日期：1998-08-01 00:00:00

abstract：:Cyanotoxins are now recognised by international and national health and environment agencies as significant health hazards. These toxins, and the cells which produce them, are also vulnerable to exploitation for illegitimate purposes. Cyanotoxins are increasingly being subjected to national and international guideline...

journal_title：Toxicology letters

authors： Metcalf JS,Meriluoto JA,Codd GA

更新日期：2006-05-25 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

journal_title：Toxicology letters

authors： Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

更新日期：2014-08-04 00:00:00

abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...

journal_title：Toxicology letters

authors： Kleinman MT,Araujo JA,Nel A,Sioutas C,Campbell A,Cong PQ,Li H,Bondy SC

更新日期：2008-05-05 00:00:00

abstract：:In order to assess the applicability of the micronucleus (MN) and G2 assays as biomarkers of in vitro radiosensitivity and cancer susceptibility, we investigated the inter- and intra-individual variation of these endpoints. For the MN assay unstimulated blood cultures from 57 healthy donors were exposed in vitro to 3....

journal_title：Toxicology letters

authors： Vral A,Thierens H,Baeyens A,De Ridder L

更新日期：2004-04-01 00:00:00

abstract：:There is sufficient evidence for pulmonary carcinogenicity of inhaled cadmium (Cd) compounds in rats whereas no such evidence was found in mice and hamsters, indicating significant species differences in the pulmonary response to inhaled Cd. We hypothesized that expression of metallothionein (MT) protein in the lung a...

journal_title：Toxicology letters

authors： Oberdörster G,Cherian MG,Baggs RB

更新日期：1994-06-01 00:00:00

abstract：:The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared wi...

journal_title：Toxicology letters

authors： Nilsson BO,Einarsson B,Magnusson C

更新日期：1991-05-01 00:00:00

abstract：:Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

journal_title：Toxicology letters

authors： De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

更新日期：1995-10-01 00:00:00

abstract：:The elution profile of urine from rats given 63Ni i.p. using a Sephadex G-25 column was studied to investigate the chemical form and pattern of nickel (Ni) excretion. Ni was excreted probably as a mixture of complexes with chemical constituents of urine (molecular weight 200-250) within 24 h after 63Ni injection. 63Ni...

journal_title：Toxicology letters

authors： Verma HS,Behari JR,Tandon SK

更新日期：1980-03-01 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:The effects of 3 weeks' or 6 months' inhalation exposure of rats to aromatic white spirit 6 h/day, 5 days/week at 0, 400, or 800 ppm were studied. Synaptosomal neurochemistry was investigated as index of the in situ conditions in the presynaptic nerve terminal. In both studies, the relative and absolute yield of synap...

journal_title：Toxicology letters

authors： Lam HR,Ostergaard G,Ladefoged O

更新日期：1995-10-01 00:00:00

abstract：:Transcription factor activator protein (AP)-1 can be activated in nitrogen-mustard-injured mouse skin, and is thought to participate in the inflammatory response. AP-1 consists of homo- or heterodimers of Fos [c-Fos, Fos-B, fos-related antigen (Fra)-1 and Fra-2] and Jun (c-Jun, JunB and JunD) family members, and infor...

journal_title：Toxicology letters

authors： Ye F,Zeng Q,Dan G,Dong X,Chen M,Sai Y,Lin H,Zou Z

更新日期：2020-02-01 00:00:00

abstract：:Cytotoxicity in terms of haemolytic potency in vitro of eight surfactants failed to correlate with in vivo rabbit eye irritancy. Ability of the same surfactants to block spontaneous contractions of mouse and rabbit isolated ileum (especially the latter), correlated better with in vivo findings in rabbit eyes. Effectiv...

journal_title：Toxicology letters

authors： Muir CK,Flower C,Van Abbé NJ

更新日期：1983-08-01 00:00:00

abstract：:Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phen...

journal_title：Toxicology letters

authors： Powley MW,Carlson GP

更新日期：2001-12-15 00:00:00

abstract：:Neurobehavioral effects of polychlorinated biphenyls (PCBs) at environmental levels of exposure have been reported in cross-sectional and prospective studies in infants and children. However, observations differ for effect spectrum, persistence and effective matrix (cord plasma, maternal plasma or milk). In order to i...

journal_title：Toxicology letters

authors： Winneke G,Bucholski A,Heinzow B,Krämer U,Schmidt E,Walkowiak J,Wiener JA,Steingrüber HJ

更新日期：1998-12-28 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:In recent years physiologically based pharmacokinetic (PBPK) modeling has found frequent application in risk assessments where PBPK models serve as important adjuncts to studies on modes of action of xenobiotics. In this regard, studies on mode of action provide insight into both the sites/mechanisms of action and the...

journal_title：Toxicology letters

authors： Andersen ME

更新日期：2003-02-18 00:00:00

abstract：:Toxic and volatile chemicals are widely used in household products and previously used as warfare agents, causing a public health threat worldwide. This study aimed to evaluate the extent of injury and mechanisms of acrolein toxicity in the cornea. Primary human corneal stromal fibroblasts cultures (hCSFs) from human ...

journal_title：Toxicology letters

authors： Gupta S,Kamil S,Sinha PR,Rodier JT,Chaurasia SS,Mohan RR

更新日期：2021-01-06 00:00:00

abstract：:Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...

journal_title：Toxicology letters

authors： Wang YH,Chen YH,Wu TN,Lin YJ,Tsai HJ

更新日期：2006-06-01 00:00:00

abstract：:Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer ...

journal_title：Toxicology letters

authors： Jones JM,Yeralan O,Hines G,Maher M,Roberts DW,Benson RW

更新日期：1990-07-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

journal_title：Toxicology letters

authors： Okey AB,Riddick DS,Harper PA

更新日期：1994-01-01 00:00:00

abstract：:A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with...

journal_title：Toxicology letters

authors： Hayashi Y,Katayama H

更新日期：1981-12-01 00:00:00

abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

journal_title：Toxicology letters

authors： Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

更新日期：2006-03-01 00:00:00

abstract：:Untargeted metabolomic approaches offer new opportunities for a deeper understanding of the molecular events related to toxic exposure. This study proposes a metabolomic investigation of biochemical alterations occurring in urine as a result of dioxin toxicity. Urine samples were collected from Czech chemical workers ...

journal_title：Toxicology letters

authors： Jeanneret F,Boccard J,Badoud F,Sorg O,Tonoli D,Pelclova D,Vlckova S,Rutledge DN,Samer CF,Hochstrasser D,Saurat JH,Rudaz S

更新日期：2014-10-15 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) has a salutary effect on hemorrhagic, traumatic and endotoxic shock. The role of FDP on compound 48/80-induced shock was therefore investigated. Sprague Dawley aged male rats (448+/-7.4 gm body weight) were randomly assigned into three groups and treated intraperitoneally with diphenhydr...

journal_title：Toxicology letters

authors： Figueroa AH,Stone RH,Cohly HH,Lehan PH,Markov AK

更新日期：2001-06-20 00:00:00

abstract：:Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effect...

journal_title：Toxicology letters

authors： Hugo P,Bernier J,Krzystyniak K,Potworowski EF,Fournier M

更新日期：1988-04-01 00:00:00

abstract：:Cellular senescence is characterized by irreversible cell arrest and is associated with the development of chronic diseases, including cancer. Here, we investigated the induction of cellular senescence during liver carcinogenesis. Liver cancer was induced in Fischer 344 rats with a weekly intraperitoneal injection of ...

journal_title：Toxicology letters

authors： Pacheco-Rivera R,Fattel-Fazenda S,Arellanes-Robledo J,Silva-Olivares A,Alemán-Lazarini L,Rodríguez-Segura M,Pérez-Carreón J,Villa-Treviño S,Shibayama M,Serrano-Luna J

更新日期：2016-01-22 00:00:00