Abrogation of graft-versus-host reaction by dieldrin in mice.

Abstract:

:Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effects of dieldrin on the T-cell immune response, using the graft-versus-host reaction (GVHR) as a model, in order to assess T-cell subset efficiency. Lymphoid cells of A/J mice injected intraperitoneally 7 days earlier with 36 mg/kg body weight dieldrin were transferred into H-2-incompatible F1 hybrids. With this model, known to induce a marked GVHR, we have observed that dieldrin inhibited the potential of parental cells to induce a GVHR in hybrid mice. This effect could not be attributed to a direct cell cytotoxicity, nor to the modulation of major T-cell subsets as shown by thymic and peripheral T-cell subpopulation analysis. Collaboration processes between these cellular subsets seem to represent a potential site for the dieldrin-induced suppression.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Hugo P,Bernier J,Krzystyniak K,Potworowski EF,Fournier M

doi

10.1016/0378-4274(88)90003-3

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

11-22

issue

1

eissn

0378-4274

issn

1879-3169

pii

0378-4274(88)90003-3

journal_volume

41

pub_type

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