Promoting effect of testosterone propionate on experimental exocrine pancreatic tumors by 4-hydroxyaminoquinoline 1-oxide in rats.

Abstract:

:A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with castration and weekly injections of testosterone propionate in a dose of 1 mg/rat after HAQO administration resulted in high incidence of the pancreatic tumors in both sexes. From these findings, it is concluded that testosterone can promote the induction of the pancreatic tumors in rats by HAQO.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Hayashi Y,Katayama H

doi

10.1016/0378-4274(81)90009-6

subject

Has Abstract

pub_date

1981-12-01 00:00:00

pages

349-54

issue

4

eissn

0378-4274

issn

1879-3169

pii

0378-4274(81)90009-6

journal_volume

9

pub_type

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