Effect of fructose-1, 6-diphosphate versus diphenhydramine on mortality in compound 48/80-induced shock.

abstract：:Adrenal weight and the concentration of corticosterone and glucose in plasma of male Wistar rats, dosed orally with fenitrothion (7.25 or 14.5 mg/kg/day) for 28 days were investigated. A significant increase in the relative weight of adrenals was observed 2 weeks after treatment commenced, but was preceded by an incre...

journal_title：Toxicology letters

authors： Yamamoto T,Egashira T,Yoshida T,Kuroiwa Y

更新日期：1982-04-01 00:00:00

abstract：:Combined effects of mycotoxin mixtures are of major concern due to the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon the fu...

journal_title：Toxicology letters

authors： Tammer B,Lehmann I,Nieber K,Altenburger R

更新日期：2007-04-25 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and depletion of striatal dopamine (DA), leading to a range of motor symptoms, including resting tremor, rigidity, bradykinesia and postural abnormalities. The neurotoxin (MPTP) and its active metabol...

journal_title：Toxicology letters

authors： Bernstein AI,O'Malley KL

更新日期：2013-05-23 00:00:00

abstract：:N-cadherin has known to be involved in tumor progression and metastasis. However, it is still obscure about the signaling pathway involving in the processing of N-cadherin. Thus, we examined which signaling pathway plays a major role in the processing of N-cadherin in C6 glioma cells following treatment of cadmium (Cd...

journal_title：Toxicology letters

authors： Jo C,Koh YH

更新日期：2013-10-24 00:00:00

abstract：:3'-Hydroxyacetanilide has been previously studied as a nontoxic regioisomer of the analgesic acetaminophen (4'-hydroxyacetanilide). The radiolabeled derivative has been shown to covalently bind to liver proteins at levels similar to that observed with hepatotoxic doses of radiolabeled acetaminophen with no evidence of...

journal_title：Toxicology letters

authors： Halmes NC,Samokyszyn VM,Hinton TW,Hinson JA,Pumford NR

更新日期：1998-01-16 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Reactive metabolites and reactive oxygen species generated during PAH metabolism are detoxified by reactions involving glutathione (GSH). Early life...

journal_title：Toxicology letters

authors： Ortiz L,Nakamura B,Li X,Blumberg B,Luderer U

更新日期：2014-10-15 00:00:00

abstract：:Epidemiological studies have demonstrated a clear association between betel nut chewing and an increased risk for oral mucosal lesions. Arecoline, the most abundant betel alkaloid, is considered the most important etiologic factor in betel nuts. In addition, most betel nut chewers are also smokers. In order to elucida...

journal_title：Toxicology letters

authors： Chang YC,Tai KW,Chou MY,Tseng TH

更新日期：2000-12-20 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism b...

journal_title：Toxicology letters

authors： Han M,Liu X,Liu S,Su G,Fan X,Chen J,Yuan Q,Xu G

更新日期：2017-05-05 00:00:00

abstract：:The distribution and acute lethality of i.v. administered 3 micrometers latex spheres were determined in rats. The results extend previous studies demonstrating the similarity between dog and rat in the dynamics of microspheres in these species and the inverse relationship between sphere diameter and hemodynamic toxic...

journal_title：Toxicology letters

authors： Yokel RA,Sabo JP,Simmons GH,DeLuca PP

更新日期：1981-10-01 00:00:00

abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...

journal_title：Toxicology letters

authors： Kleinman MT,Araujo JA,Nel A,Sioutas C,Campbell A,Cong PQ,Li H,Bondy SC

更新日期：2008-05-05 00:00:00

abstract：:A diversity of chemicals cause discrete lesions in the kidney by a number of different mechanisms, and similar types of chemicals may give rise to more than one target cell injury. Screening for these lesions in vivo may be unreliable if a single noninvasive or invasive criterion is used. Instead, evidence of nephroto...

journal_title：Toxicology letters

authors： Bach PH

更新日期：1989-03-01 00:00:00

abstract：:The fast growing applications of ZnO nanoparticles (NPs) in food sector and other fields enhance the exposure possibility of human beings to ZnO NPs including via oral administration route. Although the oral toxicity of ZnO NPs has been studied, most of the research was performed on the normal animal models. Therefore...

journal_title：Toxicology letters

authors： Du LJ,Xiang K,Liu JH,Song ZM,Liu Y,Cao A,Wang H

更新日期：2018-10-01 00:00:00

abstract：:Changes in the activities of antioxidant enzymes superoxide dismutase, catalase (CAT), glutathione peroxidase and heme oxygenase (HO) and changes in lipid peroxidation and reduced glutathione (GSH) levels were measured in the livers of control and Lewis lung carcinoma (LLC)-bearing mice 24 h after a single injection o...

journal_title：Toxicology letters

authors： Christova TY,Gorneva GA,Taxirov SI,Duridanova DB,Setchenska MS

更新日期：2003-03-03 00:00:00

abstract：:Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), ...

journal_title：Toxicology letters

authors： Jordan MC,Waller AR,Chasseaud LF,Barbhaiya RH

更新日期：1994-03-01 00:00:00

abstract：:The interaction of zinc(II) on the toxicokinetics of 2,5-hexanedione (2,5-HD), the ultimate toxic metabolite of n-hexane, was performed by quantifying the changes of two urinary biomarkers, free 2,5-HD and pyrrole derivatives, in rats exposed to 2,5-HD and to 2,5-HD plus zinc acetate. Eight groups of Wistar rats were ...

journal_title：Toxicology letters

authors： Mateus ML,dos Santos AP,Batoréu MC

更新日期：2001-02-03 00:00:00

abstract：:Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...

journal_title：Toxicology letters

authors： Lu TH,Chen CH,Lee MJ,Ho TJ,Leung YM,Hung DZ,Yen CC,He TY,Chen YW

更新日期：2010-05-04 00:00:00

abstract：:Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

journal_title：Toxicology letters

authors： Murakami T,Nagamura Y,Hirano K

更新日期：1998-01-31 00:00:00

abstract：:Cyanotoxins are now recognised by international and national health and environment agencies as significant health hazards. These toxins, and the cells which produce them, are also vulnerable to exploitation for illegitimate purposes. Cyanotoxins are increasingly being subjected to national and international guideline...

journal_title：Toxicology letters

authors： Metcalf JS,Meriluoto JA,Codd GA

更新日期：2006-05-25 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:Triphenyltin (TPT) is an organotin compound and may be an endocrine disruptor, impairing the male reproductive system. However, the effect of short-term TPT exposure on stem Leydig cell regeneration later on remains unknown. Here, we show that TPT affects stem Leydig cell regeneration in the adult rat testis. Adult ma...

journal_title：Toxicology letters

authors： Ni C,Fang Y,Chen X,Wu K,Li H,Wang Y,Zhenkun L,Lian Q,Ge RS

更新日期：2019-05-15 00:00:00

abstract：:Clinical study showed that smoking during pregnancy deceased the thymus size in newborns. However, the long-term effect remains unclear. This study was aimed to observe the effects of prenatal nicotine exposure (PNE) on the development of thymus and the T-lymphocyte subpopulation in mice offspring from the neonatal to...

journal_title：Toxicology letters

authors： Qu W,Zhao WH,Wen X,Yan HY,Liu HX,Hou LF,Ping J

更新日期：2019-04-01 00:00:00

abstract：:The co-ordinated glucuronidation and export of compounds from cells is an important determinant in the detoxification of many compounds in vivo. Many UDP-glucuronosyltransferases (UGTs) and several multidrug resistance proteins (MRPs) have been cloned and individually expressed to assess specificity of glucuronidation...

journal_title：Toxicology letters

authors： Cuff RL,Wade LT,Rychlik B,Jedlitschky GA,Burchell B

更新日期：2001-03-31 00:00:00

abstract：:The acute toxicity of organothiophosphate insecticides like parathion results from their metabolic activation by cytochromes P450. The present study is directed towards the characterization of cytochrome-P450-dependent metabolism of parathion by various mouse brain regions. Intraperitoneal administration of [35S]parat...

journal_title：Toxicology letters

authors： Soranno TM,Sultatos LG

更新日期：1992-01-01 00:00:00

abstract：:The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under th...

journal_title：Toxicology letters

authors： Katz DP,Bhattacharya D,Bhattacharya S,Deruiter J,Clark CR,Suppiramaniam V,Dhanasekaran M

更新日期：2014-09-02 00:00:00

abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1984-10-01 00:00:00

abstract：:It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1993-01-01 00:00:00

abstract：:The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg produced a concentration-dependent increase in the spontaneous efflux of DA which was independent of the availability of Ca2+ in the superfusion medium. The Ca(2+)-de...

journal_title：Toxicology letters

authors： Kalisch BE,Racz WJ

更新日期：1996-12-01 00:00:00

abstract：:Effect of sublethal concentrations (0.0083, 0.0055, 0.0041, 0.0033 and 0.0028 mg/l) of sodium penta-chlorophenate (Na-PCP) on the enzymes SDH, PDH and LDH in brain, liver and gills of Notopterus notopterus after 15 ad 30 days exposure were studied. SDH and PDH were inhibited, and LDH were stimulated significantly at m...

journal_title：Toxicology letters

authors： Verma SR,Rani S,Dalela RC

更新日期：1982-02-01 00:00:00

abstract：:We previously reported that NR2E3, an orphan nuclear receptor, plays an important role in maintaining the basal expression of estrogen receptor α (ER) and that the NR2E3 level is highly correlated with the relapse-free survival of breast cancer patients. Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-...

journal_title：Toxicology letters

authors： Khanal T,Kim D,Johnson A,Choubey D,Kim K

更新日期：2015-09-17 00:00:00

abstract：:Chlordimeform (Cdf) is readily absorbed through the skin of pesticide applicators. It also enters the body when breathed into the lungs. Cdf can be found in the urine of workers who handle or are involved in applying pesticide products which contain the chemical, even when they are wearing special protective clothing ...

journal_title：Toxicology letters

authors： Maddy KT,Knaak JB,Gibbons DB

更新日期：1986-10-01 00:00:00