Abstract：
:Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phenol. In this study the cytochrome P450 isozymes involved in the metabolism of phenol were examined in hepatic and pulmonary microsomes utilizing chemical inhibitors of CYP2E1, CYP2B, and CYP2F2 and using CYP2E1 knockout mice. CYP2E1 was found to be responsible for only approximately 50% of 20 microM phenol metabolism in the liver. This suggests another isozyme(s) is involved in hepatic phenol metabolism. In pulmonary microsomes both CYP2E1 and CYP2F2 were significantly involved.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Powley MW,Carlson GPdoi
10.1016/s0378-4274(01)00441-6keywords:
subject
Has Abstractpub_date
2001-12-15 00:00:00pages
117-23issue
1-3eissn
0378-4274issn
1879-3169pii
S0378427401004416journal_volume
125pub_type
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