The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...

journal_title：Toxicology letters

authors： Matsukura M,Koike K,Zon G

更新日期：1995-12-01 00:00:00

abstract：:Oxidative damage plays a key role in septic shock induced by lipopolysaccharide (LPS) which is known to enhance the formation of reactive oxygen species (ROS). In this study, biochemical parameters indicative of oxidative stress were tested in the rat heart following LPS challenge, with and without pretreatment with t...

journal_title：Toxicology letters

authors： Ben-Shaul V,Lomnitski L,Nyska A,Zurovsky Y,Bergman M,Grossman S

更新日期：2001-08-06 00:00:00

abstract：:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...

journal_title：Toxicology letters

authors： Subramoniam A,Husain R,Seth PK

更新日期：1991-08-01 00:00:00

abstract：:Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-...

journal_title：Toxicology letters

authors： Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

更新日期：2021-01-08 00:00:00

abstract：:Short- and medium-term rodent bioassays have been proposed under ICH guidelines for use in testing for the carcinogenic potential of pharmaceuticals. Further evaluation of these models is needed urgently and coordinated efforts are in progress worldwide to expand the available database. Models currently being investig...

journal_title：Toxicology letters

authors： Storer RD

更新日期：2000-03-15 00:00:00

abstract：:The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...

journal_title：Toxicology letters

authors： Watanabe M

更新日期：1998-12-28 00:00:00

abstract：:Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

journal_title：Toxicology letters

authors： Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

更新日期：2016-02-03 00:00:00

abstract：:Male mice (Q strain) received a single i.p. injection of 14 organophosphorus compounds, including 11 insecticides, administered on separate occasions. After a recovery period of 10 to 15 days, the cytogenic effects were analyzed in primary spermatocytes at diakinesis-metaphase I corresponding to the treatment of A4-B ...

journal_title：Toxicology letters

authors： Degraeve N,Chollet MC,Moutschen J

更新日期：1984-06-01 00:00:00

abstract：:The people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-OHPy) and 3-hydroxyb...

journal_title：Toxicology letters

authors： Lafontaine M,Champmartin C,Simon P,Delsaut P,Funck-Brentano C

更新日期：2006-04-10 00:00:00

abstract：:The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...

journal_title：Toxicology letters

authors： Nair BS,Erickson JR,Pillai R,Estrada A,Watson RR

更新日期：1991-08-01 00:00:00

abstract：:In this work the in vitro reactions of phosphine with intact red blood cells and membrane-free hemoglobin extracts are reported. We demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreve...

journal_title：Toxicology letters

authors： Potter WT,Rong S,Griffith J,White J,Garry VF

更新日期：1991-06-01 00:00:00

abstract：:alpha-Zearalanol (alpha-ZAL), a phytochemical with both antioxidant and estrogen-like properties, has been shown to retard progression of atherosclerosis and regulate cardiovascular function in part through suppression of endothelin-1 (ET-1) secretion. However, the precise nature behind alpha-ZAL-elicited inhibition o...

journal_title：Toxicology letters

authors： Xu H,Duan J,Dai S,Wu Y,Sun R,Ren J

更新日期：2008-07-10 00:00:00

abstract：:The aim of this study was to investigate the oxidative effects of Fe(2)O(3), benzo(a)pyrene (B(a)P) and pyrene, alone or in association (B(a)P or pyrene coated onto Fe(2)O(3) particles), in normal human embryonic lung epithelial cells (L132) in culture. We evaluated: (i) membrane integrity, through fatty acid release ...

journal_title：Toxicology letters

authors： Garçon G,Shirali P,Garry S,Fontaine M,Zerimech F,Martin A,Hannothiaux MH

更新日期：2000-09-30 00:00:00

abstract：:Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civ...

journal_title：Toxicology letters

authors： Holmes WW,Keyser BM,Paradiso DC,Ray R,Andres DK,Benton BJ,Rothwell CC,Hoard-Fruchey HM,Dillman JF,Sciuto AM,Anderson DR

更新日期：2016-02-26 00:00:00

abstract：:Effects of sublethal concentration (0.8 of LC50 96 h) of nickel sulphate (NiSO4 X 7H2O) on muscle glycogen and blood lactic acid levels of a freshwater teleost, Colisa fasciatus, at time intervals from 3-96 h have been recorded. Muscle glycogen levels showed a general decrease at all time intervals compared with contr...

journal_title：Toxicology letters

authors： Chaudhry HS

更新日期：1984-01-01 00:00:00

abstract：:7-Methyldeoxyguanosine (7-medG) may be a useful marker of human exposure to methylating agents at the individual level. Methods of detection, including 32P-postlabeling, HPLC with electrochemical or fluorescence detection, and immunoassays, are critically summarized. These methods have been applied to the analysis of ...

journal_title：Toxicology letters

authors： Bianchini F,Wild CP

更新日期：1994-06-01 00:00:00

abstract：:Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

journal_title：Toxicology letters

authors： Silva LR,Girard D

更新日期：2016-09-30 00:00:00

abstract：:Ambient fine particulate matter (PM2.5, particulates with an aerodynamic diameter < or = 2.5 microm) can suppress alveolar macrophage (AM) functions, but the data concerning the effects of blowing sand PM2.5 on AMs remain limited. The aim of the present study is to investigate the influences of blowing sand PM2.5 on A...

journal_title：Toxicology letters

authors： Geng H,Meng Z,Zhang Q

更新日期：2005-06-17 00:00:00

abstract：:The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under th...

journal_title：Toxicology letters

authors： Katz DP,Bhattacharya D,Bhattacharya S,Deruiter J,Clark CR,Suppiramaniam V,Dhanasekaran M

更新日期：2014-09-02 00:00:00

abstract：:The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied. MPT is often associated with opening of a Ca2+ -induced pore. The opening of this pore leads to swelling, loss of mitochondrial membrane p...

journal_title：Toxicology letters

authors： Al-Nasser IA

更新日期：1999-03-08 00:00:00

abstract：:Paracetamol (acetaminophen, APAP) is the most frequently used analgesic drug worldwide. However, patients in several specific populations can have an increased exposure to toxic APAP metabolites. Therefore, APAP-protein adducts have been proposed as an alternative marker for the assessment of APAP intoxications and as...

journal_title：Toxicology letters

authors： Delahaye L,Dhont E,De Cock P,De Paepe P,Stove CP

更新日期：2020-05-15 00:00:00

abstract：:An unusual case of fatal poisoning by delta-9-tetrahydrocannabinol (delta-9-THC)--a physiologically active constituent of cannabis--is reported. Methods of isolation and detection of delta-9-THC was estimated quantitatively by thin-layer chromatography (TLC) and photoelectric densitometry. ...

journal_title：Toxicology letters

authors： Tewari SN,Sharma JD

更新日期：1980-03-01 00:00:00

abstract：:Mouse inbred strains with inherited predisposition and resistance to lung cancer provide an essential tool for the dissection of the genetics of this complex disease. We have previously mapped a major locus (Pulmonary adenoma susceptibility 1, Pas1) affecting inherited predisposition to lung cancer in mice on chromoso...

journal_title：Toxicology letters

authors： Manenti G,Nomoto T,De Gregorio L,Gariboldi M,Stefania Falvella F,Nagao M,Dragani TA

更新日期：2000-03-15 00:00:00

abstract：:Male rats were administered diets containing monobutyl (MBP), mono-iso-butyl (MIBP), monooctyl (MOP) or mono-2-ethylhexyl phthalate (MEHP) for 1 week, and serum lipid compositions were determined. Non-esterified fatty acid was increased and triglycerides and total cholesterol were decreased in all monoester-treated gr...

journal_title：Toxicology letters

authors： Oishi S,Hiraga K

更新日期：1982-11-01 00:00:00

abstract：:Malignant gliomas are the most common and most aggressive primary brain tumor, and for which differentiation therapy has emerged as a promising candidate strategy. In this study, we used in vitro and in vivo assays to examine the differentiation effects of wogonin, a major active constituent of Scutellaria baicalensis...

journal_title：Toxicology letters

authors： Wang Y,Zhang Y,Qian C,Cai M,Li Y,Li Z,You Q,Wang Q,Hu R,Guo Q

更新日期：2013-10-24 00:00:00

abstract：:The relative deposition of inhaled heterodisperse particles of the size of environmental tobacco smoke (ETS, mass median aerodynamic diameter 0.2 micron, geometric standard deviation 1.5) is about the same in the tracheobronchial tree and is lower in the pulmonary region of the rat than in the same regions of humans. ...

journal_title：Toxicology letters

authors： Oberdörster G,Pott F

更新日期：1987-01-01 00:00:00

abstract：:Pregnant rats were exposed to 0, 100, 200, 400 or 800 ppm of carbon disulfide (CS2), 100 ppm of hydrogen sulfide (H2S) alone or in combination with 400 and 800 ppm CS2, 6 h/d during days 6-20 of gestation. Maternal reproduction and fetal parameters were evaluated on gestational day 21. Treatment with 100 or 200 ppm CS...

journal_title：Toxicology letters

authors： Saillenfait AM,Bonnet P,de Ceaurriz J

更新日期：1989-07-01 00:00:00

abstract：:The toxic mechanism of endosulfan, a widely used organochlorine pesticide, was investigated in Saccharomyces cerevisiae and human cell lines. A concentration-dependent inhibition of cell growth was observed when S. cerevisiae was exposed to endosulfan, and its cytotoxicity (IC(50)) was found to be 49 microM and 86 mic...

journal_title：Toxicology letters

authors： Sohn HY,Kwon CS,Kwon GS,Lee JB,Kim E

更新日期：2004-07-15 00:00:00

abstract：:Effect of chrysotile dust alone or together with Candida albicans administered intratracheally in guinea pigs was studied in the genesis of pleural plaques over a period of 12 months. A significant increase of mucopolysaccharides, phosphorus, calcium and -SH content was detected in pleural fluid of animals treated wit...

journal_title：Toxicology letters

authors： Saxena KC,Srivastava L,Ali S,Dogra RK

更新日期：1982-10-01 00:00:00