Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes.

abstract：:We have examined the effect of subchronic methidathion (MD) administration on vascular wall damage. The experimental groups were: control group and rats treated with 5 mg/kg MD. The MD group was given MD by gavage for 5 days a week for 4 weeks at a dose level of 5 mg/kg per day by using corn oil as the vehicle. The le...

journal_title：Toxicology letters

authors： Yavuz T,Delibas N,Yildirim B,Altuntas I,Candir O,Cora A,Karahan N,Ibrisim E,Kutsal A

更新日期：2005-01-15 00:00:00

abstract：:Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...

journal_title：Toxicology letters

authors： Imai T,Onose J,Hasumura M,Takizawa T,Hirose M

更新日期：2006-06-20 00:00:00

abstract：:Isolated rat hepatocytes incubated aerobically formed measurable amounts of ethane, a parameter for lipid peroxidation. This ethane formation increased several-fold due to carbon tetrachloride (CCl4) depending on its concentration. Cell damage as measured by trypan blue uptake and lactate dehydrogenase release poorly ...

journal_title：Toxicology letters

authors： de Ruiter N,Ottenwälder H,Muliawan H,Kappus H

更新日期：1981-06-01 00:00:00

abstract：:Inflammation and microRNAs are involved in human skin cancer; however, their molecular mechanisms remain unclear. Further, a concern in skin cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. To explore new biomarkers of chemical exposure in risk assessment of chemical carc...

journal_title：Toxicology letters

authors： Lu X,Luo F,Liu Y,Zhang A,Li J,Wang B,Xu W,Shi L,Liu X,Lu L,Liu Q

更新日期：2015-09-17 00:00:00

abstract：:Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...

journal_title：Toxicology letters

authors： Ahluwalia P,Malik VB

更新日期：1989-02-01 00:00:00

abstract：:The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...

journal_title：Toxicology letters

authors： Watanabe M

更新日期：1998-12-28 00:00:00

abstract：:The involvement of neurotrophins after radiation injury during brain development were studied in pregnant mice (C 57/B1) exposed on gestation day 15 to X-ray doses of 0.02-2 Gy. Nerve growth factor protein (NGF) and different cholinergic markers were investigated on postnatal day 1 (P1) and day 21 (P21); in situ hybri...

journal_title：Toxicology letters

authors： Dimberg Y,Vazquez M,Söderström S,Ebendal T

更新日期：1997-01-15 00:00:00

abstract：:Cimetidine, a widely prescribed, potent histamine H2-receptor antagonist, is unrelatedly a mild antiandrogen. Since perinatal androgens are essential for normal masculine imprinting, we wanted to determine if maternally administered cimetidine interfered with the development of the male offspring's sex-dependent, hepa...

journal_title：Toxicology letters

authors： Shapiro BH,Bitar MS

更新日期：1991-01-01 00:00:00

abstract：:The effects of selenium on cellular toxicity and histochemical distribution of mercury were examined in a cell culture system of mouse peritoneal macrophages. Selenium protected against the toxicity of mercury in cultures exposed to 4 microM of mercuric chloride. Selenomethionine caused a significant increase in cell ...

journal_title：Toxicology letters

authors： Christensen M,Rungby J,Mogensen SC

更新日期：1989-06-01 00:00:00

abstract：:The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...

journal_title：Toxicology letters

authors： Chen T,Yang J,Zhang H,Ren G,Yang Z,Zhang T

更新日期：2014-09-17 00:00:00

abstract：:Besides hepatotoxicity, paracetamol may exert nephrotoxic effects in experimental animals and man. The present study in rats shows that cholestyramine given 4 and 24 h after paracetamol provided protection against both hepato- and nephrotoxicity; this was evidenced by reduced increments in plasma enzyme activities (SD...

journal_title：Toxicology letters

authors： Siegers CP,Möller-Hartmann W

更新日期：1989-05-01 00:00:00

abstract：:Several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (EDCs). In three pair-matched studies we found changes in sex hormone concentrations and T-lymphocytes in relation to acute and chronic pesticide exposure. After acute exposure, 1 day later the concentrati...

journal_title：Toxicology letters

authors： Straube E,Straube W,Krüger E,Bradatsch M,Jacob-Meisel M,Rose HJ

更新日期：1999-06-30 00:00:00

abstract：:Effect of 120 days of continuous exposure of three sublethal concentrations (1/2, 1/4 and 1/8 fractions of 96 h LC50) of Basalin on alkaline phosphatase (Alk P), acid phosphatase (Acid P), lactic dehydrogenase (LDH), succinic dehydrogenase (SDH), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transamina...

journal_title：Toxicology letters

authors： Rashatwar SS,Ilyas R

更新日期：1983-05-01 00:00:00

abstract：:Effect of sublethal concentrations (0.0083, 0.0055, 0.0041, 0.0033 and 0.0028 mg/l) of sodium penta-chlorophenate (Na-PCP) on the enzymes SDH, PDH and LDH in brain, liver and gills of Notopterus notopterus after 15 ad 30 days exposure were studied. SDH and PDH were inhibited, and LDH were stimulated significantly at m...

journal_title：Toxicology letters

authors： Verma SR,Rani S,Dalela RC

更新日期：1982-02-01 00:00:00

abstract：:A simple and sensitive method for the separation of 14C-labelled acetanilide, 4-hydroxyacetanilide, 3-hydroxyacetanilide and 2-hydroxyacetanilide was developed using thin-layer chromatography. This separation is the basis for the assay of acetanilide 4-hydroxylase and acetanilide 2-hydroxylase activity in liver micros...

journal_title：Toxicology letters

authors： Lewandowski M,Chui YC,Levi P,Hodgson E

更新日期：1991-02-01 00:00:00

abstract：:This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroe...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2018-01-05 00:00:00

abstract：:In 2001 the SCOOP (SCOOP: Scientific Co-operation on Questions relating to Food) task 3.2.10 "Collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU Member States" was established. The task was divided in three subtasks (zearalenone, fumonisins and trichothece...

journal_title：Toxicology letters

authors： Schothorst RC,van Egmond HP

更新日期：2004-10-10 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00

abstract：:Triptolide (TP) is the main ingredient of Chinese herb Tripterygium wilfordii Hook f. (TWHF). Despite of its multifunction in pharmaceutics, accumulating evidences showed that TP caused obvious hepatotoxicity in clinic. The current study investigated the role of Notch1 signaling in TP-induced hepatotoxicity. Our data ...

journal_title：Toxicology letters

authors： Shen F,Xiong Z,Kong J,Wang L,Cheng Y,Jin J,Huang Z

更新日期：2019-01-01 00:00:00

abstract：:A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...

journal_title：Toxicology letters

authors： Monteith DK,Connor TH,Benvenuto JA,Fairchild EJ,Theiss JC

更新日期：1988-03-01 00:00:00

abstract：:The common food preparation processes, frying, broiling and baking, can give rise to air pollutants that are known to be mutagenic and carcinogenic in animal tests. A large number of persons can be exposed to such fumes as cooking is performed in most households and in many commercial enterprises. Additional studies o...

journal_title：Toxicology letters

authors： Löfroth G

更新日期：1994-06-01 00:00:00

abstract：:We investigated the cytotoxic effects of formaldehyde (FA) on lymphocytes. FA-exposed mice showed a profound reduction not only in the number of natural killer (NK) cells but also in the expression of NK cell-specific receptors, but these mice did not exhibit decreases in the numbers of T or B lymphocytes. FA exposure...

journal_title：Toxicology letters

authors： Kim EM,Lee HY,Lee EH,Lee KM,Park M,Ji KY,Jang JH,Jeong YH,Lee KH,Yoon IJ,Kim SM,Jeong MJ,Kim KD,Kang HS

更新日期：2013-11-25 00:00:00

abstract：:Chlordimeform (Cdf) is readily absorbed through the skin of pesticide applicators. It also enters the body when breathed into the lungs. Cdf can be found in the urine of workers who handle or are involved in applying pesticide products which contain the chemical, even when they are wearing special protective clothing ...

journal_title：Toxicology letters

authors： Maddy KT,Knaak JB,Gibbons DB

更新日期：1986-10-01 00:00:00

abstract：:The effects of flavoglaucin from Aspergillus chevalieri (Mangin) Thom et Church on mitochondrial reactions have been investigated to obtain insight into the mode of actions on biomembranes by means of isolated rat liver mitochondria. It was found that flavoglaucin exhibited a strong uncoupling effect on oxidative phos...

journal_title：Toxicology letters

authors： Kawai K,Mori H,Kitamura J

更新日期：1983-12-01 00:00:00

abstract：:This study aims to determine whether quercetin elicits a protective effect against the toxicity of chronic exposure to low-level DDVP using metabonomic technology. Rats were randomly assigned into the control, DDVP-treated, quercetin-treated, and quercetin plus DDVP-treated groups. DDVP and quercetin were given to rat...

journal_title：Toxicology letters

authors： Wang H,Li S,Qi L,Xu W,Zeng Y,Hou Y,Zhao X,Sun C

更新日期：2014-03-03 00:00:00

abstract：:One of the major dose-limiting toxicities induced by antimicrotubule antitumor agents such as vinca alkaloids and taxanes is peripheral neuropathy. The neurotoxicity of TZT-1027 (a dolastatin 10 derivative antimicrotubule agent) was thus assessed using the animal models for antimicrotubule agent-induced neurotoxicity....

journal_title：Toxicology letters

authors： Ogawa T,Mimura Y,Isowa K,Kato H,Mitsuishi M,Toyoshi T,Kuwayama N,Morimoto H,Murakoshi M,Nakayama T

更新日期：2001-04-30 00:00:00

abstract：:The aim of this study was to establish an air-liquid interface (ALI) culture of precision-cut lung slices (PCLS) for direct exposure of lung cells to gaseous contaminants. Nitrogen dioxide (NO(2)) and ozone (O(3)) were selected as model gas compounds. Acute pro-inflammatory and toxic effects of NO(2) and O(3) on live ...

journal_title：Toxicology letters

authors： Switalla S,Knebel J,Ritter D,Krug N,Braun A,Sewald K

更新日期：2010-07-01 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:Glutathione (GSH) levels, glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) as antioxidant defense system were evaluated in CHO-K1 cells after beauvericin (BEA) exposure. The effect of N-acetyl-cysteine (NAC) pre-treatment was assessed. GSH levels significantly decrease 18% a...

journal_title：Toxicology letters

authors： Mallebrera B,Font G,Ruiz MJ

更新日期：2014-05-02 00:00:00

abstract：:An atomic absorption spectrophotometric (AAS) method was successfully applied to analysis of urine for arsenic (As) as a measure of biological monitoring of occupational exposure to As in Vietnam. The application of the method to urine samples from 75 non-exposed control urbanites (after 2-day abstinence from sea food...

journal_title：Toxicology letters

authors： Dang TM,Tran QT,Vu KV

更新日期：1999-09-05 00:00:00