Effects of monosodium glutamate (MSG) on serum lipids, blood glucose and cholesterol in adult male mice.

abstract：:Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...

journal_title：Toxicology letters

authors： Miyakawa Y,Takahashi M,Furukawa F,Toyoda K,Sato H,Hayashi Y

更新日期：1986-11-01 00:00:00

abstract：:Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety a...

journal_title：Toxicology letters

authors： Abramsson-Zetterberg L,Svensson M,Johnsson L

更新日期：2007-09-10 00:00:00

abstract：:Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing...

journal_title：Toxicology letters

authors： Chung WG,Yu IJ,Park CS,Lee KH,Roh HK,Cha YN

更新日期：1999-01-11 00:00:00

abstract：:The separation and determination of 3-nitropropionic acid (NPA) in bovine urine by reverse-phase HPLC is described. The method utilizes a rapid ethyl acetate extraction and this clean-up step also improves the chromatographic resolution of NPA in bovine plasma. A simple colorimetric method is also developed for the ra...

journal_title：Toxicology letters

authors： Majak W,McDiarmid RE

更新日期：1990-02-01 00:00:00

abstract：:We examined the ability of the multidrug resistance-associated protein 1 (MRP1/ABCC1) to transport pesticides, as this transporter mediates the cellular efflux of a variety of xenobiotics, typically as glucuronide, sulfate, or glutathione conjugates. NIH3T3 cells stably expressing MRP1 were 3.37-fold more resistant to...

journal_title：Toxicology letters

authors： Tribull TE,Bruner RH,Bain LJ

更新日期：2003-04-30 00:00:00

abstract：:Aliesterases (carboxylesterases, EC 3.1.1.1) are serine esterases which may protect acetylcholinesterase during organophosphorus insecticide intoxication by providing alternative phosphorylation sites. Levels of hepatic aliesterase activity were investigated after the intraperitoneal administration of beta-naphthoflav...

journal_title：Toxicology letters

authors： Watson AM,Chambers H,Chambers JE

更新日期：1994-05-01 00:00:00

abstract：:Ethylene (ET) is the largest volume organic chemical. Mammals metabolize the olefin to ethylene oxide (EO), another important industrial chemical. The epoxide alkylates macromolecules and has mutagenic and carcinogenic properties. In order to estimate the EO burden in mice, rats, and humans resulting from inhalation e...

journal_title：Toxicology letters

authors： Filser JG,Klein D

更新日期：2018-04-01 00:00:00

abstract：:Toxicological data used for risk assessments must undergo an evaluation of reliability. Nevertheless, a reliability evaluation scheme for such data has yet to be established in China. A method termed TRAM (Toxicological data Reliability Assessment Method) was developed to evaluate toxicological data reliability. A que...

journal_title：Toxicology letters

authors： Bian Q,Ping Y,Jun W,Lyu Z,Song Y,Zhang L,Liu Z

更新日期：2019-09-01 00:00:00

abstract：:The lethal effects of d-amphetamine and phencyclidine (PCP) were compared when adult male mice were placed into isolated or aggregated (12 mice/cage) conditions. The LD50 of d-amphetamine decreased approx. 30-fold between isolated (87.9 mg/kg) and aggregated (2.8 mg/kg) conditions. In contrast, PCP showed only a 1.3-f...

journal_title：Toxicology letters

authors： Landauer MR,Balster RL

更新日期：1982-07-01 00:00:00

abstract：:Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

journal_title：Toxicology letters

authors： Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

更新日期：2019-10-15 00:00:00

abstract：:A 13-week subchronic toxicity study of thiamphenicol (TAP) was performed in F344 rats. The minimum lethal dose was estimated to be greater than 10 g/kg body weight, when a single dose of 4-10 g/kg of TAP was given orally. In the subchronic toxicity study, groups of 12 F344 rats of each sex were given solutions contain...

journal_title：Toxicology letters

authors： Ando J,Ishihara R,Imai S,Takano S,Kitamura T,Takahashi M,Yoshida M,Maekawa A

更新日期：1997-04-28 00:00:00

abstract：:In this study, we aimed to evaluate the genotoxic effects of fungicides fenarimol and propamocarb which are used to protect crops from fungi. For this reason, bone-marrow micronucleus and chromosome aberration tests were carried out in Swiss albino mice. Mice were injected with four different doses of fenarimol and pr...

journal_title：Toxicology letters

authors： Aydemir N,Bilaloğlu R

更新日期：2004-02-28 00:00:00

abstract：:Particulate air pollution is associated with cardiovascular morbidity and mortality. Fine particles with a diameter <2.5 microm (PM2.5) have an important role in triggering biological responses. These particles, and particularly the ultrafine fraction (<100 nm) penetrate deeply into the respiratory tract. Recently, we...

journal_title：Toxicology letters

authors： Nemmar A,Hoylaerts MF,Hoet PH,Nemery B

更新日期：2004-04-01 00:00:00

abstract：:This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroe...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2018-01-05 00:00:00

abstract：:Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-de...

journal_title：Toxicology letters

authors： Malik JK,Lay JP,Klein W,Korte F

更新日期：1981-03-01 00:00:00

abstract：:Administration of the chemical carcinogen 2-acetylaminofluorene (2-AAF) has previously been shown to lower hepatic epidermal growth factor (EGF) binding levels during chemically induced hepatocarcinogenesis. To further characterize the specificity of this response, EGF binding levels for liver microsomes were determin...

journal_title：Toxicology letters

authors： Ringer DP,Panzeter PL,DeCicco LA

更新日期：1997-03-14 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the...

journal_title：Toxicology letters

authors： Agrawal AK,Tilson HA,Bondy SC

更新日期：1981-03-01 00:00:00

abstract：:Monitoring of human exposure to persistent organic pollutants POPs and heavy metals have taken place since 1994 in a circumpolar study conducted under the Arctic monitoring and assessment programme (AMAP). The study has confirmed that Arctic populations relying on marine food (Inuit) have an exposure level of POPs and...

journal_title：Toxicology letters

authors： Hansen JC

更新日期：2000-03-15 00:00:00

abstract：:To characterize the accumulated hazards associated with the inhalation of gases typical of combustion products, a time-integrated value known as the fractional effective dose (FED) is used. This FED is maintained by the International Organization for Standardization (ISO) and made publicly available as the Standard IS...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2016-11-16 00:00:00

abstract：:Chloroform-induced toxicity in rodents depends on oral dose regimen. We evaluated the absorption and tissue dosimetry of chloroform after gavage administration in various vehicles to male Fischer 344 rats and female B6C3F1 mice. Animals received a single dose of chloroform in corn oil, water, or aqueous 2% emulphor at...

journal_title：Toxicology letters

authors： Dix KJ,Kedderis GL,Borghoff SJ

更新日期：1997-05-16 00:00:00

abstract：:The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under th...

journal_title：Toxicology letters

authors： Katz DP,Bhattacharya D,Bhattacharya S,Deruiter J,Clark CR,Suppiramaniam V,Dhanasekaran M

更新日期：2014-09-02 00:00:00

abstract：:Groups of Sprague-Dawley rats were dosed per os for 4 consecutive days with 0.0, 0.2, 2.0 or 4.0 mg cyclopiazonic acid (CPA)/kg body weight/day, and killed on the fifth day. Sections of liver were prepared for electron microscopic examination. Dilatation of the rough endoplasmic reticulum was observed in all hepatocyt...

journal_title：Toxicology letters

authors： Hinton DM,Morrissey RE,Norred WP,Cole RJ,Dorner J

更新日期：1985-05-01 00:00:00

abstract：:The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...

journal_title：Toxicology letters

authors： Nair BS,Erickson JR,Pillai R,Estrada A,Watson RR

更新日期：1991-08-01 00:00:00

abstract：:1. The oocyte of the African clawed toad (Xenopus laevis) offers a reliable, sensitive and disease resistant system to investigate recombinantly and endogenously expressed Ca2+ signaling G protein-coupled receptors and their intracellular signaling pathways. 2. To study receptor induced Ca2+ release, two-electrode vol...

journal_title：Toxicology letters

authors： Nietgen GW,Hönemann CW,Durieux ME

更新日期：1998-11-23 00:00:00

abstract：:The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment of Reproductive Toxicity data indicated the Agency's intention for wide use of the technique. In developmental toxicity experiments, a number of factors need t...

journal_title：Toxicology letters

authors： Foster PM,Auton TR

更新日期：1995-12-01 00:00:00

abstract：:Ebselen is a seleno-organic compound that causes cell death in several cancer cell types. The mechanisms underlying its deleterious effects have not been fully elucidated. In this study, the effects of ebselen (1 μM-40 μM) on AR42J tumor cells have been examined. Cell viability was studied using AlamarBlue(®) test. Ce...

journal_title：Toxicology letters

authors： Santofimia-Castaño P,Garcia-Sanchez L,Ruy DC,Fernandez-Bermejo M,Salido GM,Gonzalez A

更新日期：2014-09-17 00:00:00

abstract：:Human epidermal keratinocytes which have been cultured were treated with the heavy metal ions of cadmium, mercury, copper and zinc. Cytotoxicity was measured either by protein estimation or by using the neutral red assay. Antioxidants were added in order to find out whether heavy metal-induced cytotoxicity is related ...

journal_title：Toxicology letters

authors： Kappus H,Reinhold C

更新日期：1994-04-01 00:00:00

abstract：:We investigated the characteristics of hepatic cytochrome P450s and flavin-containing monooxygenase 1 (FMO1) in male Nts:Mini rats, a Wistar/Jcl-derived transgenic rat strain showing less plasma GH concentration than the parental strain. The total hepatic P450 contents of Mini rats were significantly reduced. A suppre...

journal_title：Toxicology letters

authors： Tani Y,Yamamoto H,Kawaji A,Mizuno H,Fukushige J,Hosokawa T,Doi K

更新日期：1999-06-01 00:00:00

abstract：:Nickel (Ni) can disorder testosterone synthesis in rat Leydig cells, whereas the mechanisms remain unclear. The aim of this study was to investigate the role of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) in Ni-induced disturbance of testosterone synthesis in rat Leydig cells. The testo...

journal_title：Toxicology letters

authors： Han A,Zou L,Gan X,Li Y,Liu F,Chang X,Zhang X,Tian M,Li S,Su L,Sun Y

更新日期：2018-06-15 00:00:00