当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models.

An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models.

Abstract：

:One of the major dose-limiting toxicities induced by antimicrotubule antitumor agents such as vinca alkaloids and taxanes is peripheral neuropathy. The neurotoxicity of TZT-1027 (a dolastatin 10 derivative antimicrotubule agent) was thus assessed using the animal models for antimicrotubule agent-induced neurotoxicity. Rabbits were intravenously given TZT-1027 or vincristine weekly for 5 weeks. In the mouse study, TZT-1027, vincristine or paclitaxel was intravenously given every 2 days and/or weekly. Despite the neuropathologic evidence such as myelinated axonal and fiber degeneration in the peripheral nerves and in the sensory tracts of the spinal cord following the treatment with vincristine or paclitaxel, no drug-induced alteration was observed in the TZT-1027 groups. Although there are reports that some other dolastatin derivatives with antimicrotubule activity showed no neurotoxic potential in humans, the present study represents the first demonstration in experimental animals that a dolastatin derivative has no, or at least a lower, neurotoxic potential compared to other antimicrotubule agents.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Ogawa T,Mimura Y,Isowa K,Kato H,Mitsuishi M,Toyoshi T,Kuwayama N,Morimoto H,Murakoshi M,Nakayama T

doi

10.1016/s0378-4274(01)00327-7

keywords:

subject

Has Abstract

pub_date

2001-04-30 00:00:00

pages

97-106

issue

2

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(01)00327-7

journal_volume

121

pub_type

杂志文章

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