Monitoring the urine of pesticide applicators in California for residues of chlordimeform and its metabolites 1982-1985.

abstract：:The 2,4-dinitrophenylhydrazine (2,4-DNPH) derivatization method mainly used for the determination of airborne formaldehyde was extended for acetaldehyde, acetone, 2-butanone, and cyclohexanone, the next four carbonyl compounds of industrial importance. Sampling devices and sampling conditions were adjusted for the res...

journal_title：Toxicology letters

authors： Binding N,Schilder K,Czeschinski PA,Witting U

更新日期：1998-08-01 00:00:00

abstract：:Clinical epidemiological studies have shown that there is a link between Parkinson's disease (PD) and cancer, but how PD regulates cancer development remains unknown. In our study, the effect of metabotropic glutamate receptor 5 (mGlu5) on hepatoma was explored in a rotenone-induced PD model both in vitro and in vivo....

journal_title：Toxicology letters

authors： Bai XX,Gu L,Yang HM,Xi SS,Xia N,Zhang S,Zhang H

更新日期：2018-05-15 00:00:00

abstract：:The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine (DMN)/kg and daily doses of 5 mg and 1 mg/kg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species stud...

journal_title：Toxicology letters

authors： Maduagwu EN,Anosa VO

更新日期：1981-09-01 00:00:00

abstract：:Information about the effects of phytoestrogens in the liver, the main organ of metabolism, is limited. In this study we have examined the dose dependent effects of the phytoestrogen genistein (GEN) on gene expression in rat liver in comparison to the potent estrogen ethinylestradiol (EE). Special attention was paid t...

journal_title：Toxicology letters

authors： Geis RB,Diel P,Degen GH,Vollmer G

更新日期：2005-05-16 00:00:00

abstract：:To understand the underlying mechanism for apoptosis induced by titanium dioxide nanoparticles (TNP), human airway epithelial cell line was cultured to investigate the relevant apoptosis pathways. Our results showed that the levels of reactive oxygen species and morphological apoptosis increased in a dose-dependent ma...

journal_title：Toxicology letters

authors： Shi Y,Wang F,He J,Yadav S,Wang H

更新日期：2010-06-16 00:00:00

abstract：:The peripheral-type benzodiazepine receptor (PBR), a putative receptor in Leydig cells, modulates steroidogenesis. Since benzodiazepines are commonly used in regional anesthesia, their peripheral effects need to be defined. Therefore, this study set out to investigate in vitro effects of the benzodiazepine midazolam (...

journal_title：Toxicology letters

authors： So EC,Chang YT,Hsing CH,Poon PW,Leu SF,Huang BM

更新日期：2010-02-01 00:00:00

abstract：:To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...

journal_title：Toxicology letters

authors： Nagaya T,Ishikawa N,Hata H

更新日期：1990-12-01 00:00:00

abstract：:Hydrochlorofluorocarbon 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a close structural analogue of the hepatotoxic anaesthetic halotane and a replacement for some ozone-depleting chlorofluorocarbons, is metabolized by liver cytochrome P450 (P450), both in vitro and in vivo. P450 activates HCFC-123, both oxidatively...

journal_title：Toxicology letters

authors： Zanovello A,Ferrara R,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Cadmium specifically modify amine metabolism at the central nervous system and pituitary hormone secretions. Thus, the physiological functions controlled by these hormones can be modulated by cadmium. This xenobiotic is associated with deleterious effects on the gonadal function and with changes in the secretory patte...

journal_title：Toxicology letters

authors： Lafuente A,Esquifino AI

更新日期：1999-11-22 00:00:00

abstract：:Toluene diisocyanate (TDI), a highly reactive industrial chemical is a leading cause of occupational asthma in westernized countries. It has also been reported to be a skin sensitizer in mice and guinea pigs although instances of skin sensitivity in humans are rare. It is uncertain if skin-contact is necessary to init...

journal_title：Toxicology letters

authors： Ebino K,Ueda H,Kawakatsu H,Shutoh Y,Kosaka T,Nagayoshi E,Lemus R,Karol MH

更新日期：2001-04-08 00:00:00

abstract：:Benzo(a)pyrene (B(a)P), a potent environmental procarcinogen, has been shown to cause cell cycle alternation. However, the mechanisms involved in this effect are not well understood yet. Our current results demonstrated that B(a)P exposure led to cell proliferation and a 33.5% increase in S phase cells as well as a 26...

journal_title：Toxicology letters

authors： Gao A,Liu B,Shi X,Jia X,Ye M,Jiao S,You B,Huang C

更新日期：2007-04-05 00:00:00

abstract：:Stoichiometric conversion of methyl acetate to methanol in vitro was detected when methyl acetate was incubated with blood for 2 to 8 h. The velocity of the reaction was so fast that almost all of methyl acetate disappeared in 8 h. The methanol formation was further confirmed by means of gas-chromatography-mass spectr...

journal_title：Toxicology letters

authors： Mizunuma K,Kawai T,Yasugi T,Horiguchi S,Iwami O,Ikeda M

更新日期：1992-09-01 00:00:00

abstract：:Dichloromethane (DCM) elimination and carboxyhemoglobin (COHb) generation were examined in adult female SD rats pretreated with a glutathione (GSH) depletor(s). Rats were treated with either buthionine sulfoximine (BSO; 2 mmol/kg, i.p.), diethylmaleate (DEM; 3 mmol/kg, i.p.), phorone (PHO; 1 mmol/kg, i.p.) or BSO plus...

journal_title：Toxicology letters

authors： Oh SJ,Kim SK,Kim YC

更新日期：2002-03-24 00:00:00

abstract：:The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that sacchar...

journal_title：Toxicology letters

authors： Pecevski J,Vuksanović L,Savković N,Alavantić D,Radivojević D

更新日期：1983-12-01 00:00:00

abstract：:Cadmium (Cd) has been reported to induce hypertension in both humans and animals; however, its mechanism has not been clearly elucidated. Vascular tone is one of the factors contributing to hypertension. This study was conducted to investigate the effects of Cd exposure on vascular muscarinic receptor responses to ace...

journal_title：Toxicology letters

authors： Yoopan N,Watcharasit P,Wongsawatkul O,Piyachaturawat P,Satayavivad J

更新日期：2008-01-30 00:00:00

abstract：:A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregn...

journal_title：Toxicology letters

authors： Noda T,Morita S,Yamano T,Shimizu M,Yamada A

更新日期：1991-04-01 00:00:00

abstract：:The assessment of human exposure to chemicals present in the diet is a rapidly developing discipline. The formulation of the "risk analysis paradigm" by the Codex Alimentarius Commission in 1994 defined the exposure assessment as an essential step of the risk assessment process. This has re-enforced demands to those j...

journal_title：Toxicology letters

authors： Luetzow M

更新日期：2003-04-11 00:00:00

abstract：:Lead (Pb) exposure during development impairs a variety of cognitive, behavioral and neurochemical processes resulting in deficits in learning, memory, attention, impulsivity and executive function. Numerous studies have attempted to model this effect of Pb in rodents, with the majority of studies focusing on hippocam...

journal_title：Toxicology letters

authors： Anderson DW,Mettil W,Schneider JS

更新日期：2016-03-30 00:00:00

abstract：:Methamphetamine (METH) is a widely abused psychostimulant. Lactulose is a non-absorbable sugar, which effectively decreases METH-induced neurotoxicity in rat. However, the exact mechanisms need further investigation. In this study, 5-week-old male Sprague Dawley rats received METH (15 mg/kg, 8 intraperitoneal injectio...

journal_title：Toxicology letters

authors： Xie XL,He JT,Wang ZT,Xiao HQ,Zhou WT,Du SH,Xue Y,Wang Q

更新日期：2018-06-01 00:00:00

abstract：:Cyanobacteria ("blue-green algae"), such as Oscillatoria sp., are a ubiquitous group of bacteria found in freshwater systems worldwide that are linked to illness and in some cases, death among humans and animals. Exposure to cyanobacteria occurs via ingestion of contaminated water or food-products. Exposure of the gut...

journal_title：Toxicology letters

authors： Swanson-Mungerson M,Incrocci R,Subramaniam V,Williams P,Hall ML,Mayer AMS

更新日期：2017-06-05 00:00:00

abstract：:Cocaine remains a widely abused substance. While most addicts take cocaine intranasally, a considerable number abuse cocaine by mouth. It has been assumed that after oral exposure cocaine is hydrolyzed in the stomach rendering it ineffective. This study investigated the effect of orally administered cocaine on liver f...

journal_title：Toxicology letters

authors： Labib R,Turkall R,Abdel-Rahman MS

更新日期：2001-12-15 00:00:00

abstract：:The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after ...

journal_title：Toxicology letters

authors： Ernst E

更新日期：1990-05-01 00:00:00

abstract：:Dysregulated cell proliferation and tumorigenesis is frequently encountered in several cancers including hepatocellular carcinogenesis (HCC). Thus, agents that inhibit cell proliferation and restrain hepatic tumorigenesis through cell cycle regulation have a beneficial effect in the treatment of hepatocellular carcino...

journal_title：Toxicology letters

authors： Raghunandhakumar S,Paramasivam A,Senthilraja S,Naveenkumar C,Asokkumar S,Binuclara J,Jagan S,Anandakumar P,Devaki T

更新日期：2013-10-23 00:00:00

abstract：:Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development of lung cancers have suggested a synergism between arsenit...

journal_title：Toxicology letters

authors： Pang Y,Xu Y,Li H,Li Y,Zhao Y,Jiang R,Shen L,Zhou J,Wang X,Liu Q

更新日期：2013-04-12 00:00:00

abstract：:It is known in humans and mouse models, that drinking water exposures to arsenite (As+3) leads to immunotoxicity. Previously, our group showed that certain types of immune cells are extremely sensitive to arsenic induced genotoxicity. In order to see if cells from different immune organs have differential sensitivitie...

journal_title：Toxicology letters

authors： Xu H,McClain S,Medina S,Lauer FT,Douillet C,Liu KJ,Hudson LG,Stýblo M,Burchiel SW

更新日期：2016-11-16 00:00:00

abstract：:Pneumotoxicity and lethality resulting from administration of methylcyclopentadienyl manganese tricarbonyl (MMT) and its 2 major metabolites in rats were compared. Following i.p. injection, MMT was found to have an LD50 value of 12.1 mg/kg. Neither of the metabolites appeared to have significant acute toxicity even wh...

journal_title：Toxicology letters

authors： Cox DN,Traiger GJ,Jacober SP,Hanzlik RP

更新日期：1987-11-01 00:00:00

abstract：:The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

journal_title：Toxicology letters

authors： Ohhira S,Matsui H,Watanabe K

更新日期：2000-11-20 00:00:00

abstract：:Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

journal_title：Toxicology letters

authors： De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

更新日期：1995-10-01 00:00:00

abstract：:Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

journal_title：Toxicology letters

authors： Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

更新日期：2018-10-15 00:00:00

abstract：:Monocytes, separated from human peripheral blood, were preincubated with different polycyclic aromatic hydrocarbons (PAHs) for 24 h and the production of superoxide ions (O*2-) was then measured using as a stimulating agent phorbol 12-myristate 13-acetate. A significantly enhanced O*2- production is only observed when...

journal_title：Toxicology letters

authors： Fabiani R,De Bartolomeo A,Rosignoli P,Sebastiani B,Morozzi G

更新日期：1999-10-29 00:00:00