In vitro hydrolysis of methyl acetate, a limitation in application of head-space gas-chromatography in biological monitoring of exposure.

abstract：:Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

journal_title：Toxicology letters

authors： Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

更新日期：2012-02-05 00:00:00

abstract：:Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...

journal_title：Toxicology letters

authors： Trombetta D,Mondello MR,Cimino F,Cristani M,Pergolizzi S,Saija A

更新日期：2005-12-15 00:00:00

abstract：:The aim of this study is to predict dermal permeability of four phenolic biocides in four different formulations using a linear solvation energy relationship (LSER) approach, with a calibrated flow through diffusion cell system. Mathematical descriptors were determined in the laboratory, by mathematical computations, ...

journal_title：Toxicology letters

authors： Vijay V,Yeatts JL Jr,Riviere JE,Baynes RE

更新日期：2007-12-10 00:00:00

abstract：:Over the last twenty years research has provided an important insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of immunostimulating drugs and adjuvants. In this article we provide an update of the present knowledge relating to the various par...

journal_title：Toxicology letters

authors： Batista-Duharte A,Lindblad EB,Oviedo-Orta E

更新日期：2011-06-10 00:00:00

abstract：:Malathion was applied to roses in three Finnish greenhouses by hand held lance sprayers. The potential dermal exposure of applicators to this insecticide was measured. Total urine production of each applicator was also collected up to 24 h post application. In the urine samples the specific metabolite of malathion, ma...

journal_title：Toxicology letters

authors： Tuomainen A,Kangas JA,Meuling WJ,Glass RC

更新日期：2002-08-05 00:00:00

abstract：:A direct continuous spectrophotometric assay to measure pyrethroid-cleaving enzymes in human serum was developed using cis- and trans-alpha-naphthyl-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate (cis- and trans-naphthyl-Cl2CA). These substrates show a structure very similar to the pyrethroids most often use...

journal_title：Toxicology letters

authors： Butte W,Kemper K

更新日期：1999-06-30 00:00:00

abstract：:The toxicity of diethylene glycol butyl ether (DGBE), and its principal metabolite, butoxyethoxyacetic acid (BEAA), were assessed in vitro for rat and human red blood cells. Rat erythrocytes showed evidence of mild hemolysis when exposed to BEAA at concentrations of 5 or 10 mM for 4 h. BEAA treated rat red blood cells...

journal_title：Toxicology letters

authors： Udden MM

更新日期：2005-03-28 00:00:00

abstract：:A diversity of chemicals cause discrete lesions in the kidney by a number of different mechanisms, and similar types of chemicals may give rise to more than one target cell injury. Screening for these lesions in vivo may be unreliable if a single noninvasive or invasive criterion is used. Instead, evidence of nephroto...

journal_title：Toxicology letters

authors： Bach PH

更新日期：1989-03-01 00:00:00

abstract：:Bothrops (lance-head pit vipers) venoms are rich in weaponised metalloprotease enzymes (SVMP). These toxic enzymes are structurally diverse and functionally versatile. Potent coagulotoxicity is particularly important for prey capture (via stroke-induction) and relevant to human clinical cases (due to consumption of cl...

journal_title：Toxicology letters

authors： Sousa LF,Bernardoni JL,Zdenek CN,Dobson J,Coimbra F,Gillett A,Lopes-Ferreira M,Moura-da-Silva AM,Fry BG

更新日期：2020-10-15 00:00:00

abstract：:This study aims to determine whether quercetin elicits a protective effect against the toxicity of chronic exposure to low-level DDVP using metabonomic technology. Rats were randomly assigned into the control, DDVP-treated, quercetin-treated, and quercetin plus DDVP-treated groups. DDVP and quercetin were given to rat...

journal_title：Toxicology letters

authors： Wang H,Li S,Qi L,Xu W,Zeng Y,Hou Y,Zhao X,Sun C

更新日期：2014-03-03 00:00:00

abstract：:We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

journal_title：Toxicology letters

authors： Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

更新日期：2001-03-08 00:00:00

abstract：:α-asarone is a natural phenylpropene found in several plants, which are widely used for flavoring foods and treating diseases. Previous studies have demonstrated that α-asarone has many pharmacological functions, while some reports indicated its toxicity. However, little is known about its cardiovascular effects. This...

journal_title：Toxicology letters

authors： Shang X,Ji X,Dang J,Wang L,Sun C,Liu K,Sik A,Jin M

更新日期：2020-05-15 00:00:00

abstract：:In order to assess the applicability of the micronucleus (MN) and G2 assays as biomarkers of in vitro radiosensitivity and cancer susceptibility, we investigated the inter- and intra-individual variation of these endpoints. For the MN assay unstimulated blood cultures from 57 healthy donors were exposed in vitro to 3....

journal_title：Toxicology letters

authors： Vral A,Thierens H,Baeyens A,De Ridder L

更新日期：2004-04-01 00:00:00

abstract：:Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final ma...

journal_title：Toxicology letters

authors： Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

更新日期：2000-03-15 00:00:00

abstract：:(1) The hypothesis that inhalational anesthetics affect G-protein linked alpha2 adrenergic signaling pathway was investigated using human platelets as a model system. (2) Alpha2 receptor stimulation by UK-14304, a potent and selective agonist, inhibits cAMP production induced by prostaglandin I2 (PGI2). (3) Brief stim...

journal_title：Toxicology letters

authors： Pentyala S,Moller D,Chowdhury A,Sung KY,Rebecchi M

更新日期：1998-11-23 00:00:00

abstract：:Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990s. In this study, we examined the effect of organoph...

journal_title：Toxicology letters

authors： Hirosawa N,Ueyama J,Kondo T,Kamijima M,Takagi K,Fujinaka S,Hirate A,Hasegawa T,Wakusawa S

更新日期：2011-05-30 00:00:00

abstract：:Metallothionein (MT) is a low-molecular-weight and sulfur-rich protein that is induced by not only heavy metals but also physiological stresses such as fasting and restraint stresses. Although MT plays a role as a radical scavenger and a regulator of metabolism of metals, the biological function of MT induced by fasti...

journal_title：Toxicology letters

authors： Kondoh M,Kamada K,Kuronaga M,Higashimoto M,Takiguchi M,Watanabe Y,Sato M

更新日期：2003-08-28 00:00:00

abstract：:Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strate...

journal_title：Toxicology letters

authors： Ferraguti G,Ciolli P,Carito V,Battagliese G,Mancinelli R,Ciafrè S,Tirassa P,Ciccarelli R,Cipriani A,Messina MP,Fiore M,Ceccanti M

更新日期：2017-06-05 00:00:00

abstract：:In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...

journal_title：Toxicology letters

authors： Navarra P,Martire M,del Carmine R,Pozzoli G,Preziosi P

更新日期：1992-12-01 00:00:00

abstract：:Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

journal_title：Toxicology letters

authors： Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

更新日期：2019-10-15 00:00:00

abstract：:To test the hypothesis that 3-7 ring polycyclic aromatic hydrocarbons (PAHs) are responsible for the prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS), the present study evaluates the PDT potency of DMSO-extracts of 7 heavy fuel oils (HFO), varying in their PAH content, and 1 highly...

journal_title：Toxicology letters

authors： Kamelia L,de Haan L,Ketelslegers HB,Rietjens IMCM,Boogaard PJ

更新日期：2019-10-15 00:00:00

abstract：:Enzymatic activities of Na+/K+-ATPase and Mg2+ -ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to prevent and recover the CuSO4-induced inhibition. The influence of experimentally added CuSO4 and E...

journal_title：Toxicology letters

authors： Vasić V,Jovanović D,Krstić D,Nikezić G,Horvat A,Vujisić L,Nedeljković N

更新日期：1999-10-29 00:00:00

abstract：:A matched case-control study was conducted to examine the relationship between chromium (Cr) exposure and variation in mitochondrial (mt) DNA methylation. We enrolled 29 pairs of subjects in this study; Cr exposure was confirmed in the cases by detecting blood Cr and other metal ion concentrations. DNA damage caused b...

journal_title：Toxicology letters

authors： Yang L,Xia B,Yang X,Ding H,Wu D,Zhang H,Jiang G,Liu J,Zhuang Z

更新日期：2016-01-22 00:00:00

abstract：:3'-Hydroxyacetanilide has been previously studied as a nontoxic regioisomer of the analgesic acetaminophen (4'-hydroxyacetanilide). The radiolabeled derivative has been shown to covalently bind to liver proteins at levels similar to that observed with hepatotoxic doses of radiolabeled acetaminophen with no evidence of...

journal_title：Toxicology letters

authors： Halmes NC,Samokyszyn VM,Hinton TW,Hinson JA,Pumford NR

更新日期：1998-01-16 00:00:00

abstract：:It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...

journal_title：Toxicology letters

authors： Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

更新日期：2012-09-03 00:00:00

abstract：:Cultured human proximal tubule cell monolayers maintained on permeable supports were treated simultaneously with the aminoglycoside antibiotic, gentamicin, and poly-L-aspartic acid (PAA), an inhibitor of aminoglycoside nephrotoxicity. Following 4 days of exposure, cell monolayers were placed into Ussing chambers to al...

journal_title：Toxicology letters

authors： Todd JH,Hottendorf GH

更新日期：1997-02-07 00:00:00

abstract：:Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg(0). In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were stu...

journal_title：Toxicology letters

authors： Harari R,Harari F,Gerhardsson L,Lundh T,Skerfving S,Strömberg U,Broberg K

更新日期：2012-08-13 00:00:00

abstract：:Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative tox...

journal_title：Toxicology letters

authors： Sharma H,Hirko AC,King MA,Liu B

更新日期：2018-12-15 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:Dysregulated cell proliferation and tumorigenesis is frequently encountered in several cancers including hepatocellular carcinogenesis (HCC). Thus, agents that inhibit cell proliferation and restrain hepatic tumorigenesis through cell cycle regulation have a beneficial effect in the treatment of hepatocellular carcino...

journal_title：Toxicology letters

authors： Raghunandhakumar S,Paramasivam A,Senthilraja S,Naveenkumar C,Asokkumar S,Binuclara J,Jagan S,Anandakumar P,Devaki T

更新日期：2013-10-23 00:00:00