Abstract：
:A matched case-control study was conducted to examine the relationship between chromium (Cr) exposure and variation in mitochondrial (mt) DNA methylation. We enrolled 29 pairs of subjects in this study; Cr exposure was confirmed in the cases by detecting blood Cr and other metal ion concentrations. DNA damage caused by Cr exposure was determined in terms of binucleated micronucleus frequency (BNMN) and mtDNA copy number. Finally, a Sequenom MassARRAY platform was applied to inspect the DNA methylation levels of mitochondrially encoded tRNA phenylalanine (MT-TF), mitochondrially encoded 12S RNA (MT-RNR1), and long interspersed nucleotide element-1 (LINE-1) genes. The blood Cr ion concentration and micronucleus frequency of the Cr-exposed group were higher than those of the control group, whereas the mtDNA copy number remained unchanged. The methylation levels of MT-TF and MT-RNR1 but not LINE-1 were significantly lower in Cr-exposed workers. Pearson correlation analysis showed that workers with higher blood Cr ion concentrations exhibited lower MT-TF and MT-RNR1 gene methylation, and multiple linear regression analysis indicated that CpG sites 1 and 2 in MT-TF and CpG site 6 in MT-RNR1 were affected. These results suggested that methylation level of mtDNA has the possibility of acting as an alternative effect biomarker for Cr exposure.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Yang L,Xia B,Yang X,Ding H,Wu D,Zhang H,Jiang G,Liu J,Zhuang Zdoi
10.1016/j.toxlet.2015.11.031subject
Has Abstractpub_date
2016-01-22 00:00:00pages
1-6eissn
0378-4274issn
1879-3169pii
S0378-4274(15)30126-0journal_volume
243pub_type
杂志文章abstract：:Aminoglycoside antibiotics play an integral role in antimicrobial chemotherapy. Unfortunately, these drugs are known to cause nephrotoxicity in man and experimental animals. In fact, the incidence of renal dysfunction during the course of clinical treatment with aminoglycoside antibiotics is approximately 10%. Over th...
journal_title：Toxicology letters
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更新日期：1992-12-01 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2004-05-02 00:00:00
abstract：:Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. These findings provoked the present in vitro study which was designed to determine the inhibition, aging, spontaneou...
journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2017-10-20 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(95)03482-x
更新日期：1995-12-01 00:00:00
