Abstract:
:The mutagenicity of four chemical compounds to strain TA100 of S. typhimurium was affected differently by liver S-9 preparations from untreated Sprague-Dawley rats and from rainbow trout (Salmogairdneri). These two species were equally effective in decreasing the direct mutagenicity of sodium dichromate. Rat preparations were totally inactive and trout preparations were slightly active in producing mutagenic metabolites from benzo(a)pyrene (BP). Conversely, rat homogenates were significantly more efficient in activating aflatoxin B1 (AFB1) and, in particular, 2-aminofluorene (2-AF).
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
de Flora S,Zanacchi P,Bennicelli C,Arillo Adoi
10.1016/0378-4274(82)90228-4subject
Has Abstractpub_date
1982-03-01 00:00:00pages
345-9issue
4eissn
0378-4274issn
1879-3169pii
0378-4274(82)90228-4journal_volume
10pub_type
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journal_title:Toxicology letters
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doi:10.1016/0378-4274(88)90149-x
更新日期:1988-11-01 00:00:00
abstract::The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under th...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:1992-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.06.017
更新日期:2012-09-03 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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abstract::This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroe...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2004-04-21 00:00:00
abstract::Melamine can cause urinary stones related to nephropathy of the kidney and hyperplasia or carcinoma of the bladder, but the mechanism of stone formation is not well understood. In this study, male rats were administered melamine for thirteen weeks to establish melamine bladder stone models and the stones were analysed...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.05.017
更新日期:2012-08-03 00:00:00
abstract::The effect of zinc (Zn) administration on the uptake and retention of cadmium (Cd), copper (Cu) and Zn in liver, kidneys and testes of cadmium exposed rats was investigated. Exposure to Cd caused a significant increase in the uptake of these metals in the 3 organs. The administration of Zn after the Cd exposure had li...
journal_title:Toxicology letters
pub_type: 杂志文章
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abstract::Oxidative stress has been pointed as an important molecular mechanism for liver injury in methylmercury (MeHg) poisoning. Ebselen, a seleno-organic compound that possesses anti-oxidant properties, is a useful therapeutic agent used in clinical situations involving oxidative stress. Here, we examined the possible in vi...
journal_title:Toxicology letters
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更新日期:2004-02-02 00:00:00
abstract::Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a hig...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2009.04.020
更新日期:2009-08-25 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(90)90150-k
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2009-06-22 00:00:00
abstract::A physiologically based pharmacokinetic (PBPK) model describing the disposition of 2-butoxyethanol (2-BE) was developed in order to predict the urinary concentration of its major metabolite, butoxyacetic acid (BAA) under a range of exposure scenarios. Based on Corley et al. [Corley, R.A., Bormett, G.A., Ghanayem, B.I....
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pub_type: 杂志文章
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更新日期:2006-04-10 00:00:00
abstract::Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg(0). In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were stu...
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pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2006.12.003
更新日期:2007-02-28 00:00:00