Abstract:
:The effect of zinc (Zn) administration on the uptake and retention of cadmium (Cd), copper (Cu) and Zn in liver, kidneys and testes of cadmium exposed rats was investigated. Exposure to Cd caused a significant increase in the uptake of these metals in the 3 organs. The administration of Zn after the Cd exposure had little effect on the level of these metals.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Behari JR,Tandon SKdoi
10.1016/0378-4274(80)90165-4subject
Has Abstractpub_date
1980-02-01 00:00:00pages
151-4issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(80)90165-4journal_volume
5pub_type
杂志文章abstract::Prior research suggests that sex hormones and metabolic changes, such as obesity and hyperglycemia, can alter renal transporter expression in rodents. The purpose of this study was to characterize the expression of kidney efflux transporters and regulatory transcription factors in response to Type I diabetes and pregn...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.04.008
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abstract::Whole-body inhalation exposures to N,N-dimethylacetamide (DMAC) were conducted with male rats (Crl:CD BR) and mice (Crl:CD-1 (ICR)BR). Exposure concentrations were 50, 150, 300 and 500 ppm. The exposure routines consisted of single 1-, 3-, or 6-h exposures and ten 6-h exposures (10 exposure days in 2 weeks). Area unde...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90061-2
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.03.005
更新日期:2013-05-23 00:00:00
abstract::Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1989-02-01 00:00:00
abstract::Aim of this pilot study was to correlate the human exposure to formaldehyde (F) with N-methylenvaline, a molecular adduct formed by addiction of F to the N-terminal valine in hemoglobin. A group of 21 subjects employed in a plywood factory and a laminate factory, and occupationally exposed to F, together with a group ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.07.016
更新日期:2006-02-08 00:00:00
abstract::Cisplatin, a widely used chemotherapeutic drug, causes ototoxicity in a large percentage of patients. The purpose of this study was to determine the efficacy of epicatechin (EC) as an otoprotective agent to prevent cisplatin toxicity and to investigate the molecular mechanism of EC. The effects of EC on cisplatin-indu...
journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2009-12-15 00:00:00
abstract::Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.06.032
更新日期:2014-08-17 00:00:00
abstract::Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 80 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Pretreatment with the gamma-glutamyltransp...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
abstract::The effects of halothane, 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) and 1,1-dichloro-1-fluoroethane (HCFC-141b) on the P450 system in olfactory and hepatic microsomes of bovine and rat have been investigated. In the in vitro experiments, all three compounds decreased olfactory CYP-dependent activities in microsome...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00323-x
更新日期:2001-10-15 00:00:00
abstract::Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of infl...
journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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更新日期:1980-03-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2010.04.011
更新日期:2010-07-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.03.005
更新日期:2008-05-30 00:00:00
abstract::The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg produced a concentration-dependent increase in the spontaneous efflux of DA which was independent of the availability of Ca2+ in the superfusion medium. The Ca(2+)-de...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(96)03787-3
更新日期:1996-12-01 00:00:00
abstract::Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety a...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2007.07.006
更新日期:2007-09-10 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.06.028
更新日期:2011-09-10 00:00:00
abstract::Zinc chloride (0.01 mM kept for 3h) is not toxic to cultured cerebellar granule neurons (CGNs) while kainate (0.1mM kept for 3h) demonstrates some but very low toxicity towards these cells. Measurements of the relative intraneuronal zinc ion concentration showed that increase in [Zn(2+)](i) under the simultaneous acti...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.10.003
更新日期:2012-01-05 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.07.006
更新日期:2006-01-25 00:00:00
abstract::Developmental toxicity testing according to current international guidelines involves exposure of pregnant animals, mostly rats and rabbits, and subsequent assessment of toxic effects in their fetuses. Alternative methods have been developed since the early 1980s. They include cell differentiation assays using either ...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/j.toxlet.2003.12.029
更新日期:2004-04-01 00:00:00
abstract::Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. These findings provoked the present in vitro study which was designed to determine the inhibition, aging, spontaneou...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.10.009
更新日期:2011-01-15 00:00:00
abstract::Lead (Pb) exposure during development impairs a variety of cognitive, behavioral and neurochemical processes resulting in deficits in learning, memory, attention, impulsivity and executive function. Numerous studies have attempted to model this effect of Pb in rodents, with the majority of studies focusing on hippocam...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.01.011
更新日期:2016-03-30 00:00:00