Stimulation of DNA synthesis after a single administration of cadmium nitrate.

Abstract:

:The effect of a single intravenous (i.v.) injection of cadmium nitrate was investigated in livers of male Wistar rats. A significant increase in liver weight, accompanied by an elevation of total hepatic DNA content was observed. DNA synthesis as measured by the incorporation of [3H]thymidine, was found to be 6 times greater than the control, at 24 h after treatment, and remained elevated over a period of 72 h. This elevation in DNA synthesis was not a consequence of cell necrosis, since no increase of serum glutamate-pyruvate transaminase (SGPT) activity was observed.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Ledda-Columbano GM,Columbano A,Coni PP,Vargiu M,Liguori C,Pani P

doi

10.1016/0378-4274(84)90020-1

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

267-72

issue

3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(84)90020-1

journal_volume

23

pub_type

杂志文章
  • Yohimbine prevents the effect of morphine on the redox status of neuroblastomaxglioma NG108-15 cells.

    abstract::The alpha(2)-adrenoceptor antagonist yohimbine is known to interact with the effects of opioid receptor agonists in vivo, and thus could modulate the action of morphine-like analgesics. The focus of the present work was to further study these interactions in a cell culture endowed with opioid and alpha(2)-adrenoceptor...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.05.010

    authors: Polanco MJ,Alguacil LF,Albella B,Segovia JC,González-Martín C

    更新日期:2009-09-10 00:00:00

  • Dietary pyrrolizidine (Senecio) alkaloids and tissue distribution of copper and vitamin A in broiler chickens.

    abstract::The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fe...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90017-e

    authors: Huan J,Cheeke PR,Lowry RR,Nakaue HS,Snyder SP,Whanger PD

    更新日期:1992-09-01 00:00:00

  • An assessment of the genotoxicity of vanadium.

    abstract::The activities of vanadium oxide (V2O3), vanadyl sulfate (VOSO4) and ammonium metavanadate (NH4VO3) in inducing sister chromatid exchange (SCE) and chromosomal aberrations (CAb) were assayed in Chinese hamster ovary cells. The toxic concentrations (TC50) for these compounds were found to be 25, 23 and 16 micrograms el...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(90)90026-i

    authors: Owusu-Yaw J,Cohen MD,Fernando SY,Wei CI

    更新日期:1990-02-01 00:00:00

  • Chromosome damage induced by carboplatin (CBDCA).

    abstract::The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)03202-i

    authors: González Cid M,Mudry M,Larripa I

    更新日期:1995-03-01 00:00:00

  • A repeated dose study of the toxicity of CR applied to the skin of mice.

    abstract::Dibenz (b,f)-1-4 oxazepine (CR) was applied to the skin of C3H and Porton-strain mice, daily for 12 weeks. After a further 80 weeks the animals were sacrificed and examined grossly and histologically. The results were compared with appropriate solvent and untreated controls. No abnormalities were found that could be a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:

    authors: Marrs TC,Gray MI,Colgrave HF,Gall D

    更新日期:1982-10-01 00:00:00

  • Dichlorodiphenyltrichloroethane suppresses neurite outgrowth and induces apoptosis in PC12 pheochromocytoma cells.

    abstract::It is well known that dichlorodiphenyltrichloroethane (DDT) is used as an insecticide and prevents many people in the tropical zone from devastating malaria. On the other hand, a number of reports have indicated that it may act as an endocrine disruptor and also has possible carcinogenic effects. However, the effects ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00401-0

    authors: Shinomiya N,Shinomiya M

    更新日期:2003-02-03 00:00:00

  • Ageing, a factor aggravating chronic toxicity of cadmium.

    abstract::Two groups, each of 4 rabbits, 17 and 4 months old, respectively, were given s.c. administrations of cadmium (Cd) at a dose level of 0.5 mg/kg/day 6 times per week for up to 32 weeks. In 17-month-old rabbits, low-molecular-weight proteinuria appeared in the 3rd week, proteinuria, glycosuria and anemia in the 6th week;...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90123-x

    authors: Nomiyama K,Nomiyama H,Yotoriyama M

    更新日期:1980-09-01 00:00:00

  • Hemoglobin adducts as biomarkers of estrogen homeostasis: elevation of estrogenquinones as a risk factor for developing breast cancer in Taiwanese women.

    abstract::The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.01.004

    authors: Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

    更新日期:2014-03-21 00:00:00

  • Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.

    abstract::New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.01.010

    authors: Richter LHJ,Herrmann J,Andreas A,Park YM,Wagmann L,Flockerzi V,Müller R,Meyer MR

    更新日期:2019-05-01 00:00:00

  • Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice.

    abstract::Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days sub...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90141-9

    authors: Rattner BA,Michael SD

    更新日期:1985-01-01 00:00:00

  • The effect of different anesthetics on tumor cytotoxicity by natural killer cells.

    abstract::A number of retrospective studies have suggested that choice of anesthetic drugs during surgical tumor resection might affect tumor recurrence/metastasis, or outcome of patients. The recent study showed that volatile anesthetics-based general anesthesia was associated with the worse outcomes than intravenous anestheti...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.12.007

    authors: Tazawa K,Koutsogiannaki S,Chamberlain M,Yuki K

    更新日期:2017-01-15 00:00:00

  • DNA damage by filtered, tar- and aerosol-free cigarette smoke in rodent cells: a novel evaluation.

    abstract::Nuclear accumulation of the tumorsuppressor protein p53 indicates the occurrence of chromatin injury (J. Cancer Res. Clin. Oncol. 1991, 117, 30; Oncogene 1993, 8, 307) and may be used as an analytical tool to detect genotoxic agents. This mechanism was used to evaluate the DNA-damaging potency (clastogenicity) of the ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03711-3

    authors: Hess RD,Brandner G

    更新日期:1996-11-01 00:00:00

  • Effects of zinc toxicity on thyroid function and histology in broiler chicks.

    abstract::Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, an...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90205-k

    authors: Dean CE,Hargis BM,Hargis PS

    更新日期:1991-08-01 00:00:00

  • Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep.

    abstract::Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and applicat...

    journal_title:Toxicology letters

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.toxlet.2019.10.021

    authors: Lautz LS,Dorne JLCM,Oldenkamp R,Hendriks AJ,Ragas AMJ

    更新日期:2020-02-01 00:00:00

  • The effect of copper deficiency on adriamycin toxicity.

    abstract::The effect of copper (Cu) deficiency on antioxidant status of liver and heart and its effect on adriamycin toxicity was assessed. Weanling rats were fed Cu-adequate (+Cu) and Cu-deficient (-Cu) diets for 3 weeks and then injected intraperitoneally once with saline or adriamycin (8 mg/kg). All -Cu rats had increased he...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90141-r

    authors: Fischer J,Johnson MA,Tackett RL

    更新日期:1991-07-01 00:00:00

  • Differential mechanisms of action are involved in chlorpyrifos effects in estrogen-dependent or -independent breast cancer cells exposed to low or high concentrations of the pesticide.

    abstract::It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.06.017

    authors: Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

    更新日期:2012-09-03 00:00:00

  • Pathogenic factors in aminoglycoside-induced nephrotoxicity.

    abstract::Aminoglycoside antibiotics play an integral role in antimicrobial chemotherapy. Unfortunately, these drugs are known to cause nephrotoxicity in man and experimental animals. In fact, the incidence of renal dysfunction during the course of clinical treatment with aminoglycoside antibiotics is approximately 10%. Over th...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(90)90067-v

    authors: Kacew S,Bergeron MG

    更新日期:1990-05-01 00:00:00

  • Hormones and testis development and the possible adverse effects of environmental chemicals.

    abstract::Development of a fetus into a phenotypic male depends, first, on testis formation and second, on hormone production by the fetal testis. Disorders of testicular hormone production or action can lead in severe cases to phenotypic abnormalities or can predispose towards impaired reproductive health. Evidence for deterio...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(01)00298-3

    authors: Sharpe RM

    更新日期:2001-03-31 00:00:00

  • Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing.

    abstract::Betel quid chewing, which contributes high concentration of safrole in saliva, is a popular oral habit in Taiwan. Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known. Here, we used LC/ESI-ITMS(n) and LC/QTOF-MS confirmed safrole-dGMP as reference standard to dete...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2008.09.013

    authors: Chung YT,Chen CL,Wu CC,Chan SA,Chi CW,Liu TY

    更新日期:2008-12-15 00:00:00

  • Strategies for use of biological markers of exposure.

    abstract::A major public health concern is the degree to which environmental or occupational exposures to exogenous chemicals result in adverse health effects. Biological markers have the potential for helping to answer this important question by providing links between markers of exposures and markers of early stages of the de...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(95)03569-9

    authors: Henderson RF

    更新日期:1995-12-01 00:00:00

  • Conceptual approaches for treatment of phosgene inhalation-induced lung injury.

    abstract::Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.10.010

    authors: Holmes WW,Keyser BM,Paradiso DC,Ray R,Andres DK,Benton BJ,Rothwell CC,Hoard-Fruchey HM,Dillman JF,Sciuto AM,Anderson DR

    更新日期:2016-02-26 00:00:00

  • Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

    abstract::Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.07.019

    authors: Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

    更新日期:2018-10-15 00:00:00

  • Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration.

    abstract::Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondrial protein that is thought to play a role in the pathophysiology of A...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.12.012

    authors: Fišar Z,Musílek K,Benek O,Hroch L,Vinklářová L,Schmidt M,Hroudová J,Raboch J

    更新日期:2021-03-15 00:00:00

  • Determination of arsenic in urine by atomic absorption spectrophotometry for biological monitoring of occupational exposure to arsenic.

    abstract::An atomic absorption spectrophotometric (AAS) method was successfully applied to analysis of urine for arsenic (As) as a measure of biological monitoring of occupational exposure to As in Vietnam. The application of the method to urine samples from 75 non-exposed control urbanites (after 2-day abstinence from sea food...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(99)00087-9

    authors: Dang TM,Tran QT,Vu KV

    更新日期:1999-09-05 00:00:00

  • Effect of pesticides on the growth of aquatic hyphomycetes.

    abstract::The effect of two herbicides (paraquat and 2,4-dichlorophenoxybutyric acid) and two fungicides (mancozeb and captafol) was studied on the growth of Flagellospora penicillioides, Lunulospora curvula and Phalangispora constricta using the poisoned-food technique. The pesticides did not produce any inhibition of growth a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(89)90058-1

    authors: Chandrashekar KR,Kaveriappa KM

    更新日期:1989-09-01 00:00:00

  • Cardiomyopathy in Soman and Sarin intoxicated rats.

    abstract::Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90192-5

    authors: Singer AW,Jaax NK,Graham JS,McLeod CG Jr

    更新日期:1987-05-01 00:00:00

  • Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats.

    abstract::Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90199-6

    authors: Jordan MC,Waller AR,Chasseaud LF,Barbhaiya RH

    更新日期:1994-03-01 00:00:00

  • Differential expression of the phthalate syndrome in male Sprague-Dawley and Wistar rats after in utero DEHP exposure.

    abstract::Exposure to phthalate esters during sexual differentiation disrupts testosterone and insulin-like three hormones resulting in malformations of androgen- and insulin-like three-dependent tissues. The current study was designed to test the hypothesis that gubernacular lesions would be more prevalent in the DEHP-treated ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2007.03.004

    authors: Wilson VS,Howdeshell KL,Lambright CS,Furr J,Earl Gray L Jr

    更新日期:2007-05-15 00:00:00

  • Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats.

    abstract::Anti-androgenic chemicals alter sexual differentiation by a variety of mechanisms, and the mechanisms between phthalate esters and p,p'-DDE are considered to be different. We performed an in utero through lactational exposure assay using dicyclohexyl phthalate and p,p'-DDE to investigate the sexual differentiation of ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.04.023

    authors: Yamasaki K,Okuda H,Takeuchi T,Minobe Y

    更新日期:2009-08-25 00:00:00

  • Toxicogenomics: challenges and opportunities.

    abstract::Toxicogenomics describes the measurement of global gene expression changes in biological samples exposed to toxicants. This new technology promises to greatly facilitate research into toxicant mechanisms, with the possibility of assisting in the detection of compounds with the potential to cause adverse health effects...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(02)00500-3

    authors: Orphanides G

    更新日期:2003-04-11 00:00:00