Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells.

abstract：:There has been a significant evolution in the clinical management of the poisoned patient over the last decade. Interventions that were once the cornerstone of treating the poisoned patient have become passé or have come under intense scrutiny. The advent of evidence-based medicine has forced clinical scientists to re...

journal_title：Toxicology letters

authors： Krenzelok EP

更新日期：2002-02-28 00:00:00

abstract：:Retinoic acid, an oxidative metabolite of vitamin A, is involved in the control of many biological processes including embryonic development and excess as well as deficiency of retinoids has been found to be teratogenic. The effects of retinoids in normal as well as abnormal development may be mediated by two members ...

journal_title：Toxicology letters

authors： Nau H

更新日期：1995-12-01 00:00:00

abstract：:In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p. Hepatoxicity was assessed b...

journal_title：Toxicology letters

authors： Carlson GP

更新日期：1996-06-01 00:00:00

abstract：:Fenvalerate (Fen), widely used for its high insecticidal potency and low mammalian toxicity, is classified as an endocrine-disrupting chemical. Recently, Fen has received great attention for its adverse effects on human reproductive health. In this study, we found that Fen (10 microM) had a stimulatory effect on the g...

journal_title：Toxicology letters

authors： Gao X,Yu L,Castro L,Moore AB,Hermon T,Bortner C,Sifre M,Dixon D

更新日期：2010-07-15 00:00:00

abstract：:Nickel (Ni) can disorder testosterone synthesis in rat Leydig cells, whereas the mechanisms remain unclear. The aim of this study was to investigate the role of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) in Ni-induced disturbance of testosterone synthesis in rat Leydig cells. The testo...

journal_title：Toxicology letters

authors： Han A,Zou L,Gan X,Li Y,Liu F,Chang X,Zhang X,Tian M,Li S,Su L,Sun Y

更新日期：2018-06-15 00:00:00

abstract：:The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination behaviour in simple solutions and assess the effects of complex formation upon skin permeatio...

journal_title：Toxicology letters

authors： Staff K,Brown MB,Chilcott RP,Hider RC,Jones SA,Kong XL

更新日期：2011-05-10 00:00:00

abstract：:There is potential for oral exposure of humans to styrene (ST) such as from migration of residual levels in polystyrene food containers. After absorption, ST is metabolised to styrene-7,8-oxide (SO), an alkylating epoxide. Hence, a comparison of blood burdens of SO resulting from oral exposures to ST was made with SO ...

journal_title：Toxicology letters

authors： Filser JG,Gelbke HP

更新日期：2016-04-15 00:00:00

abstract：:Long-term excessive intake of fluoride (F) could lead to chronic fluorosis. To explore the underlying molecular mechanisms, present study is designed to elucidate the effect of fluoride on proteome expression of bone in sodium fluoride (NaF)-treated SD rats. Hematoxylin and eosin (H&E) staining was used to determine t...

journal_title：Toxicology letters

authors： Wei Y,Zeng B,Zhang H,Chen C,Wu Y,Wang N,Wu Y,Zhao D,Zhao Y,Iqbal J,Shen L

更新日期：2018-07-01 00:00:00

abstract：:In recent years physiologically based pharmacokinetic (PBPK) modeling has found frequent application in risk assessments where PBPK models serve as important adjuncts to studies on modes of action of xenobiotics. In this regard, studies on mode of action provide insight into both the sites/mechanisms of action and the...

journal_title：Toxicology letters

authors： Andersen ME

更新日期：2003-02-18 00:00:00

abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...

journal_title：Toxicology letters

authors： Soni M,Nomiyama H,Nomiyama K

更新日期：1990-12-01 00:00:00

abstract：:Iodinated contrast media (CM) can induce apoptosis and necrosis of renal tubular cells. The injuries of endothelial cells induced by CM on the systemic condition have not been fully understood. To assess the toxic effects of non-ionic CM on the glomerular and aortic endothelial cells, iopromide and iodixanol, two kind...

journal_title：Toxicology letters

authors： Zhao Y,Tao Z,Xu Z,Tao Z,Chen B,Wang L,Li C,Chen L,Jia Q,Jia E,Zhu T,Yang Z

更新日期：2011-05-10 00:00:00

abstract：:Prenatal stress is known to affect the development of the brain, and exaggerate the developmental toxicity of chemicals. Many studies of developmental neurotoxicity (DNT) use pregnant rodents mated at the supplier, which consequently suffer from the stress of shipping and of environmental changes. Here, we demonstrate...

journal_title：Toxicology letters

authors： Ogawa T,Kuwagata M,Hori Y,Shioda S

更新日期：2007-11-01 00:00:00

abstract：:Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and...

journal_title：Toxicology letters

authors： Bolden AL,Rochester JR,Kwiatkowski CF

更新日期：2017-10-05 00:00:00

abstract：:Triphenyltin (TPT) is an organotin compound and may be an endocrine disruptor, impairing the male reproductive system. However, the effect of short-term TPT exposure on stem Leydig cell regeneration later on remains unknown. Here, we show that TPT affects stem Leydig cell regeneration in the adult rat testis. Adult ma...

journal_title：Toxicology letters

authors： Ni C,Fang Y,Chen X,Wu K,Li H,Wang Y,Zhenkun L,Lian Q,Ge RS

更新日期：2019-05-15 00:00:00

abstract：:The effects of zinc on the lipid components of carp erythrocytes (Cyprinus carpio L.) were studied on red blood cells exposed to ZnSO4 (0.01-1 mM) for 20 h. The temperatures of the incubation medium were 5 and 20 degrees C for carp collected in winter and summer, respectively. It was observed that increase in the conc...

journal_title：Toxicology letters

authors： Teresa G,Anna A,Maria P,Zofia J,Gerard B

更新日期：2002-06-07 00:00:00

abstract：:The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. H...

journal_title：Toxicology letters

authors： Nandan SD,Rao MS

更新日期：1982-11-01 00:00:00

abstract：:Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cell...

journal_title：Toxicology letters

authors： Kim HG,Hwang YP,Jeong HG

更新日期：2009-05-22 00:00:00

abstract：:Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...

journal_title：Toxicology letters

authors： Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sawada N,Mori M

更新日期：1999-07-30 00:00:00

abstract：:The possible embryotoxic effects of cyclohexylamine hydrochloride doses (expressed as free base) of 10, 30 and 100 mg/kg of body weight per day administered orally in water to mice and rats from the 6th to 15th day post-coitum were investigated. Treatment with daily doses of up to 100 mg/kg of body weight to mice and ...

journal_title：Toxicology letters

authors： Lorke D,Machemer L

更新日期：1983-06-01 00:00:00

abstract：:Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing...

journal_title：Toxicology letters

authors： Chung WG,Yu IJ,Park CS,Lee KH,Roh HK,Cha YN

更新日期：1999-01-11 00:00:00

abstract：:The elution profile of urine from rats given 63Ni i.p. using a Sephadex G-25 column was studied to investigate the chemical form and pattern of nickel (Ni) excretion. Ni was excreted probably as a mixture of complexes with chemical constituents of urine (molecular weight 200-250) within 24 h after 63Ni injection. 63Ni...

journal_title：Toxicology letters

authors： Verma HS,Behari JR,Tandon SK

更新日期：1980-03-01 00:00:00

abstract：:Chromium (Cr) is widely used in industry, making its toxicity a matter of concern. Although hexavalent Cr [Cr(VI)] can promote cancer cell proliferation in several cancers, there is little evidence implicating Cr(VI) in cancer cell migration, especially in prostate cancer. We show that the Cr concentration is higher i...

journal_title：Toxicology letters

authors： Zhang C,Cai K,Feng Q,Xu Y,Zhang Z

更新日期：2019-01-01 00:00:00

abstract：:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechani...

journal_title：Toxicology letters

authors： Feyereisen R

更新日期：1995-12-01 00:00:00

abstract：:The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

journal_title：Toxicology letters

authors： Ohhira S,Matsui H,Watanabe K

更新日期：2000-11-20 00:00:00

abstract：:Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990s. In this study, we examined the effect of organoph...

journal_title：Toxicology letters

authors： Hirosawa N,Ueyama J,Kondo T,Kamijima M,Takagi K,Fujinaka S,Hirate A,Hasegawa T,Wakusawa S

更新日期：2011-05-30 00:00:00

abstract：:Troglitazone (Tro) is a thiazolidinedione antidiabetic drug that was withdrawn from the market due to its association with idiosyncratic severe liver injury. Tro has never induced liver injury in experimental animals in vivo. It was assumed that the species differences between human and experimental animals in the pha...

journal_title：Toxicology letters

authors： Kakuni M,Morita M,Matsuo K,Katoh Y,Nakajima M,Tateno C,Yokoi T

更新日期：2012-10-02 00:00:00

abstract：:Amitriptyline hydrochloride, an antidepressant drug, was tested in mice for mutagenic effects in the somatic cells by the micronucleus test and in the germ cells by the air drying technique of Evans et al. Mice were treated orally with the drug at a dose of 70, 140 and 210 mg/kg body weight. The results indicate that ...

journal_title：Toxicology letters

authors： Chowdary PS,Rao MS

更新日期：1987-12-01 00:00:00

abstract：:Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and youn...

journal_title：Toxicology letters

authors： Patel E,Reynolds M

更新日期：2013-10-09 00:00:00

abstract：:Reports on adverse health effects related to occupational exposure to toner powder are still inconclusive. Therefore, we have previously conducted an in vitro-study to characterize the genotoxic potential of three commercially available black printer toner powders in A549 lung cells. In these cell-based assays it was ...

journal_title：Toxicology letters

authors： Könczöl M,Weiß A,Gminski R,Merfort I,Mersch-Sundermann V

更新日期：2013-02-04 00:00:00

abstract：:Increasing evidences suggest that microcystins, a kind of toxic metabolites, produced by cyanobacteria in contaminated water may contribute to the aggravation of the human colorectal carcinoma. Our previous study showed that microcystin-LR (MC-LR) exposure caused significant invasion and migration of colorectal cancer...

journal_title：Toxicology letters

authors： Ren Y,Yang M,Chen M,Zhu Q,Zhou L,Qin W,Wang T

更新日期：2017-01-04 00:00:00