Abstract:
:Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 80 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Pretreatment with the gamma-glutamyltranspeptidase (gamma-GT) inactivator AT-125 (Acivin, 50 mg/kg i.p., plus 50 mg/kg p.o., reduced the number of damaged tubules by 59 and 58% in mice treated with HCBD and MeHg, respectively. Pretreatment with the two beta-lyase inhibitors, amino-oxyacetic acid (AOAA, 3 x 100 mg/kg p.o.) and DL-propargylglycine (PPG, 300 mg/kg i.p. plus 300 mg/kg p.o.), reduced HCBD nephrotoxicity by 46 and 59%, respectively, but did not protect against MeHg nephrotoxicity. The results support a role for gamma-GT and beta-lyase in the mouse renal toxicity of HCBD and implicate gamma-GT but not beta-lyase in MeHg-induced nephrotoxicity in mice.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
de Ceaurriz J,Ban Mdoi
10.1016/0378-4274(90)90017-gsubject
Has Abstractpub_date
1990-02-01 00:00:00pages
249-56issue
2-3eissn
0378-4274issn
1879-3169pii
0378-4274(90)90017-Gjournal_volume
50pub_type
杂志文章abstract::The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2004-03-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(84)90169-3
更新日期:1984-03-01 00:00:00
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journal_title:Toxicology letters
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更新日期:1998-05-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(85)90032-3
更新日期:1985-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2002-07-21 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.06.002
更新日期:2015-09-02 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2006.02.003
更新日期:2006-08-20 00:00:00
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journal_title:Toxicology letters
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pub_type: 杂志文章,评审
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Toxicology letters
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更新日期:1993-03-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1999-12-20 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00340-x
更新日期:2001-05-19 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2019-12-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1998-11-23 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(89)90058-1
更新日期:1989-09-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1986-02-01 00:00:00
abstract::The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment of Reproductive Toxicity data indicated the Agency's intention for wide use of the technique. In developmental toxicity experiments, a number of factors need t...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03584-2
更新日期:1995-12-01 00:00:00