Abstract:
:Benzene is a human leukemogen, and a bone marrow toxin and carcinogen in experimental animals. The reactive intermediates involved in benzene toxicity and their mechanism(s) of action have not been clearly delineated. We have investigated the clastogenic and cytotoxic effects of trans,trans-muconaldehyde (MUC), a reactive ring-opened benzene metabolite, in mouse bone marrow cells in vivo. Micronucleus formation was significantly increased when CD-1 mice were treated ip with MUC at 4 and 6 mg/kg/day for two days. These results suggest that leukemogenesis by benzene may be attributable, in part, to MUC-related clastogenic and cytotoxic effects in the bone marrow cells.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Oshiro Y,Balwierz PS,Witz Gdoi
10.1016/s0378-4274(01)00340-xkeywords:
subject
Has Abstractpub_date
2001-05-19 00:00:00pages
159-66issue
3eissn
0378-4274issn
1879-3169pii
S037842740100340Xjournal_volume
121pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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