Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid.

abstract：:According to European laws animal testing in cosmetic industry will be prohibited in a few years and it will be replaced by alternative methods based on cell and tissue culture. Many ingredients of cosmetic formulations are potentially causes of skin inflammation and sensibilization. Since cytotoxicity is known, among...

journal_title：Toxicology letters

authors： Parodi A,Sanguineti R,Catalano M,Penco S,Pronzato MA,Scanarotti C,Bassi AM

更新日期：2010-02-01 00:00:00

abstract：:A wholesomeness feeding study was carried out in mice fed equal amounts of cod or redfish, comprising 45% of the diet. Three groups of animals received either irradiated [1.75 kGy (175 krad)] fish, non-irradiated fish or stock ration. A 90-day subchronic study, a multigeneration reproduction, a dominant lethality and ...

journal_title：Toxicology letters

authors： van Petten LE,Calkins JE,McConnell RF,Gottschalk HM,Elias PS

更新日期：1980-12-01 00:00:00

abstract：:In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p. Hepatoxicity was assessed b...

journal_title：Toxicology letters

authors： Carlson GP

更新日期：1996-06-01 00:00:00

abstract：:Exposure to cyanide from gari, a popular cassava food in West Africa, is implicated in the causation of ataxic polyneuropathy and amblyopia, but this has been questioned because cyanide was not detected in gari in a study. This study was carried out to determine if gari is a source of exposure to cyanide. Gari (150 g)...

journal_title：Toxicology letters

authors： Oluwole OS,Onabolu AO,Sowunmi A

更新日期：2002-09-05 00:00:00

abstract：:Exposition to cadmium (Cd) has been linked to bone metabolism alterations and occurrence of osteoporosis. Despite its known renal toxicity which indirectly disrupts bone metabolism through impairment of vitamin D synthesis, increasing evidence argues for the direct action of Cd on bone-forming osteoblasts. Indeed, acc...

journal_title：Toxicology letters

authors： Lizotte J,Abed E,Signor C,Malu DT,Cuevas J,Kevorkova O,Sanchez-Dardon J,Satoskar A,Scorza T,Jumarie C,Moreau R

更新日期：2012-12-17 00:00:00

abstract：:Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cell...

journal_title：Toxicology letters

authors： Kim HG,Hwang YP,Jeong HG

更新日期：2009-05-22 00:00:00

abstract：:The pregnane X receptor (PXR) has been established to induce chemoresistance and metabolic diseases. Ochratoxin A (OTA), a mycotoxin, decreases the expression of PXR protein in human primary hepatocytes. OTA is chlorinated and has a methylated lactone ring. Both structures are associated with OTA toxicity. The study w...

journal_title：Toxicology letters

authors： Shen Y,Shi Z,Fan JT,Yan B

更新日期：2020-10-10 00:00:00

abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1984-10-01 00:00:00

abstract：:The toxicity of methylmercury is sufficiently high to justify an evaluation of the risk from the consumption of contaminated food. In the method of risk assessment proposed here, distribution frequencies are assigned to the parameters in question, rather than mean values. Total body burden is estimated by numerical si...

journal_title：Toxicology letters

authors： Magnaval R,Batti R,Bouville A,Magnaval JP,Spear RC

更新日期：1982-02-01 00:00:00

abstract：:The distribution and acute lethality of i.v. administered 3 micrometers latex spheres were determined in rats. The results extend previous studies demonstrating the similarity between dog and rat in the dynamics of microspheres in these species and the inverse relationship between sphere diameter and hemodynamic toxic...

journal_title：Toxicology letters

authors： Yokel RA,Sabo JP,Simmons GH,DeLuca PP

更新日期：1981-10-01 00:00:00

abstract：:Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

journal_title：Toxicology letters

authors： Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

更新日期：2014-04-07 00:00:00

abstract：:The clinical use of gentamicin (G) is limited because of its nephrotoxic potential. The administration of G (50 mg/kg) to rats in a 10-day daily treatment gave a biphasic pattern of lactate dehydrogenase (LDH) and N-acetyl-beta-D-glucosaminidase (NAG) excretion. Alkaline phosphatase (ALP) was highly elevated during th...

journal_title：Toxicology letters

authors： Obatomi DK,Plummer DT

更新日期：1995-01-01 00:00:00

abstract：:A number of studies have demonstrated that co-exposure to low levels of melamine and cyanuric acid elicits renal toxicity due to the formation of melamine cyanurate crystals in the kidney nephrons. In this work, we investigated if co-exposure of rats to these compounds leads to alterations in the expression of the gen...

journal_title：Toxicology letters

authors： Camacho L,Kelly KP,Beland FA,Gamboa da Costa G

更新日期：2011-10-10 00:00:00

abstract：:We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

journal_title：Toxicology letters

authors： Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

更新日期：2001-03-08 00:00:00

abstract：:In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later. In DBA/2 mice, neither AHH nor transferase activit...

journal_title：Toxicology letters

authors： Nemoto N,Takayama S

更新日期：1980-01-01 00:00:00

abstract：:The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fe...

journal_title：Toxicology letters

authors： Huan J,Cheeke PR,Lowry RR,Nakaue HS,Snyder SP,Whanger PD

更新日期：1992-09-01 00:00:00

abstract：:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechani...

journal_title：Toxicology letters

authors： Feyereisen R

更新日期：1995-12-01 00:00:00

abstract：:The molecular basis of the interindividual differences of normal individuals to ionizing radiation is poorly understood. Several studies in telomerase KO mice with short telomeres have uncovered an inverse relationship between telomere length and radiation sensitivity. The present work aims to determine if chromosome ...

journal_title：Toxicology letters

authors： Castella M,Puerto S,Creus A,Marcos R,Surralles J

更新日期：2007-07-30 00:00:00

abstract：:Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...

journal_title：Toxicology letters

authors： Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sawada N,Mori M

更新日期：1999-07-30 00:00:00

abstract：:The effect of sorbic acid alone and in combination with sodium nitrite has been studied on bone marrow chromosomes of mice following 30 days oral treatment. Bone marrow of mice exposed to sorbic acid (15 mg/kg) and sorbic acid nitrite (7.5-1 mg/kg) showed an increase in mitotic index indicating that the drugs had an e...

journal_title：Toxicology letters

authors： Banerjee TS,Giri AK

更新日期：1986-05-01 00:00:00

abstract：:Trihalomethanes (THMs; chloroform, bromoform, bromodichloromethane, dibromochloromethane), formed as by-products of chlorine disinfection, are found to occur in combination in drinking water supplies. THMs are metabolized by cytochromes P-450 and are likely substrates of CYP2E1. Therefore, it is possible that mixed ex...

journal_title：Toxicology letters

authors： Luciene da Silva M,Charest-Tardif G,Krishnan K,Tardif R

更新日期：1999-05-20 00:00:00

abstract：:Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

journal_title：Toxicology letters

authors： Ali SF,Newport GD,Slikker W Jr,Bondy SC

更新日期：1987-03-01 00:00:00

abstract：:Silica exposure results in an initially acute inflammatory response followed by chronic fibrotic change. The mechanism for the maintenance of silica-induced inflammation has not been understood yet. In silica-induced acute inflammation and chronic fibrosis, various mediators such as reactive oxygen species, cytokines ...

journal_title：Toxicology letters

authors： Lim Y,Kim JH,Kim KA,Chang HS,Park YM,Ahn BY,Phee YG

更新日期：1999-09-05 00:00:00

abstract：:Coumarin and its derivatives are widely employed as a fragrance in cosmetics and skin care products. The skin absorption level and possible disruption to the skin by topical application of coumarins were evaluated in this study. Percutaneous absorption of osthole, daphnoretin, coumarin, byakangelicin, and 7-hydroxycou...

journal_title：Toxicology letters

authors： Pan TL,Wang PW,Aljuffali IA,Leu YL,Hung YY,Fang JY

更新日期：2014-04-21 00:00:00

abstract：:Activation of the cold-receptor TRPM8 by menthol or other tobacco additives can suppress natural defense reactions such as coughing that usually would become effective as involuntary resistance against the inhalation of fumes. In Europe menthol is only regulated as flavor, but can be used as additive as long as no cha...

journal_title：Toxicology letters

authors： Paschke M,Tkachenko A,Ackermann K,Hutzler C,Henkler F,Luch A

更新日期：2017-04-05 00:00:00

abstract：:The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We re...

journal_title：Toxicology letters

authors： Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo A

更新日期：2017-01-04 00:00:00

abstract：:Nonylphenol (NP) is a representative endocrine disruptor that has an adverse effect on male reproduction and posses direct hazard to Sertoli cells, but the mechanism remains incompletely elucidated. In the present study, based on the structural comparability and high affinity between NP and membrane phospholipid molec...

journal_title：Toxicology letters

authors： Gong Y,Pan X,Huang Y,Gao Z,Yu H,Han X

更新日期：2008-12-15 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:The classical way to demonstrate the efficiency of remediation is measuring the reduction of toxic compounds in the environment. Nevertheless, more important is the risk reduction in human health. To determine changing health effects, exposure and bio-effects have to be monitored at time of and during remediation. Kin...

journal_title：Toxicology letters

authors： Rolle-Kampczyk UE,Rehwagen M,Franck U,Weiss H,Krumbiegel P,Herbarth O

更新日期：2006-04-10 00:00:00

abstract：:Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

journal_title：Toxicology letters

authors： Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

更新日期：2020-10-01 00:00:00