Abstract:
:The molecular basis of the interindividual differences of normal individuals to ionizing radiation is poorly understood. Several studies in telomerase KO mice with short telomeres have uncovered an inverse relationship between telomere length and radiation sensitivity. The present work aims to determine if chromosome radiosensitivity is correlated with telomere length in healthy individuals. With this purpose, individual radiosensitivity was determined by the micronucleus assay in peripheral blood lymphocytes from two groups of individuals of the same age but with highly heterogeneous telomere length, selected from a population of 181 individuals where we previously measured telomere length. Our study demonstrates that telomere length modulates chromosome in vitro radiosensitivity in healthy individuals as the group with short telomeres presented higher frequencies of ionizing radiation-induced micronuclei when compared to the long telomeres group. This result supports the conclusion that individual telomere length acts as biomarker of individual chromosome instability upon exposure to ionizing radiation.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Castella M,Puerto S,Creus A,Marcos R,Surralles Jdoi
10.1016/j.toxlet.2007.05.012subject
Has Abstractpub_date
2007-07-30 00:00:00pages
29-36issue
1-2eissn
0378-4274issn
1879-3169pii
S0378-4274(07)00151-8journal_volume
172pub_type
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