Abstract:
:Gaseous butadiene (BUT) was mutagenic towards S. typhimurium strain TA 1530 when the incubation mixture was supplemented with a NADPH-fortified rat liver microsomal preparation; mutagenicity increased with the dose. A significant mutagenic effect was similarly observed when the petri dishes, containing the bacteria but no metabolic activation system, were incubated in the presence of butadiene, in a desiccator in which plates containing the S-9 rat liver fraction had been placed. This indirect mutagenic effect was attributed to the formation, by the S-9 mix, of volatile intermediate(s) that migrated and induced mutations in neighbouring bacteria.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
de Meester C,Poncelet F,Roberfroid M,Mercier Mdoi
10.1016/0378-4274(80)90179-4subject
Has Abstractpub_date
1980-08-01 00:00:00pages
125-30issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(80)90179-4journal_volume
6pub_type
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更新日期:1994-02-01 00:00:00
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更新日期:1982-08-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2013-06-07 00:00:00
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更新日期:1991-05-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1999-11-22 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2019-05-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2020.11.017
更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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doi:10.1016/j.toxlet.2009.01.001
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doi:10.1016/j.toxlet.2010.05.007
更新日期:2010-09-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-11-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90170-8
更新日期:1994-04-01 00:00:00
abstract::The lethal effects of d-amphetamine and phencyclidine (PCP) were compared when adult male mice were placed into isolated or aggregated (12 mice/cage) conditions. The LD50 of d-amphetamine decreased approx. 30-fold between isolated (87.9 mg/kg) and aggregated (2.8 mg/kg) conditions. In contrast, PCP showed only a 1.3-f...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1982-07-01 00:00:00
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journal_title:Toxicology letters
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更新日期:1998-12-28 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2016-02-03 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1994-07-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.11.004
更新日期:2018-02-01 00:00:00
abstract::N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90193-5
更新日期:1983-05-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.02.003
更新日期:2013-04-26 00:00:00