Abstract:
:Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA synthesis was significantly suppressed with 1 mM GM; (2) GM-induced decrease in GAA synthesis was recognized during incubation longer than 15 min; (3) furosemide significantly enhanced the suppression of GAA synthesis by GM. The results obtained parallel with those in the whole animal thus making GAA synthesis in tubular suspension a valid system for evaluating the GM-induced proximal tubular damage.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Takeda M,Jung KY,Sekine T,Endou H,Koide Hdoi
10.1016/0378-4274(95)03411-0subject
Has Abstractpub_date
1995-11-15 00:00:00pages
85-9issue
2-3eissn
0378-4274issn
1879-3169pii
0378-4274(95)03411-0journal_volume
81pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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pub_type: 杂志文章
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