Guanidinoacetic acid (GAA) synthesis in rat tubular suspension as a system for evaluating gentamicin (GM) nephrotoxicity.

Abstract:

:Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA synthesis was significantly suppressed with 1 mM GM; (2) GM-induced decrease in GAA synthesis was recognized during incubation longer than 15 min; (3) furosemide significantly enhanced the suppression of GAA synthesis by GM. The results obtained parallel with those in the whole animal thus making GAA synthesis in tubular suspension a valid system for evaluating the GM-induced proximal tubular damage.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Takeda M,Jung KY,Sekine T,Endou H,Koide H

doi

10.1016/0378-4274(95)03411-0

subject

Has Abstract

pub_date

1995-11-15 00:00:00

pages

85-9

issue

2-3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(95)03411-0

journal_volume

81

pub_type

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