Guanidinoacetic acid (GAA) synthesis in rat tubular suspension as a system for evaluating gentamicin (GM) nephrotoxicity.

abstract：:When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...

journal_title：Toxicology letters

authors： Gearhart JM,Mahle DA,Greene RJ,Seckel CS,Flemming CD,Fisher JW,Clewell HJ 3rd

更新日期：1993-05-01 00:00:00

abstract：:Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it can interfere with steroid biosynthesis and metabolism. However, the mechanism is unclear. The objective of the present study is to investigate the effects of BPA on two isoforms of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2)...

journal_title：Toxicology letters

authors： Guo J,Yuan X,Qiu L,Zhu W,Wang C,Hu G,Chu Y,Ye L,Xu Y,Ge RS

更新日期：2012-11-30 00:00:00

abstract：:Numerous chemicals released into the environment by man are able to disrupt the functioning of the endocrine system by binding to estrogen receptors in estrogen-responsive cells. The ability of o,p'-dichlorodiphenyl trichloroethane (DDT) and methoxychlor to compete with estradiol for binding to estrogen receptors in M...

journal_title：Toxicology letters

authors： vom Saal FS,Nagel SC,Palanza P,Boechler M,Parmigiani S,Welshons WV

更新日期：1995-05-01 00:00:00

abstract：:The effects of vitamin C on acute paracetamol poisoning were studied in mice. Given orally at 50, 100 or 200 mg/kg, either simultaneously or 2 h after the oral administration of 875 mg/kg of paracetamol, vitamin C did not cause any decrease in the mortality rate. In similar conditions in previous experiments methionin...

journal_title：Toxicology letters

authors： Romero-Ferret C,Mottot G,Legros J,Margetts G

更新日期：1983-08-01 00:00:00

abstract：:Clinical epidemiological studies have shown that there is a link between Parkinson's disease (PD) and cancer, but how PD regulates cancer development remains unknown. In our study, the effect of metabotropic glutamate receptor 5 (mGlu5) on hepatoma was explored in a rotenone-induced PD model both in vitro and in vivo....

journal_title：Toxicology letters

authors： Bai XX,Gu L,Yang HM,Xi SS,Xia N,Zhang S,Zhang H

更新日期：2018-05-15 00:00:00

abstract：:Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative tox...

journal_title：Toxicology letters

authors： Sharma H,Hirko AC,King MA,Liu B

更新日期：2018-12-15 00:00:00

abstract：:A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...

journal_title：Toxicology letters

authors： Monteith DK,Connor TH,Benvenuto JA,Fairchild EJ,Theiss JC

更新日期：1988-03-01 00:00:00

abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

journal_title：Toxicology letters

authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

更新日期：1980-12-01 00:00:00

abstract：:Several in vivo and in vitro studies have assessed methods of evaluating the cardio toxicity of compounds during drug development due to its importance for predicting human toxicity. However, in vivo/in vitro relationships have not yet been reported using a zebrafish model. This study determined the bradycardia of 15 ...

journal_title：Toxicology letters

authors： Park MJ,Lee KR,Shin DS,Chun HS,Kim CH,Ahn SH,Bae MA

更新日期：2013-01-10 00:00:00

abstract：:The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

journal_title：Toxicology letters

authors： Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

更新日期：2014-03-21 00:00:00

abstract：:Alkyl hydroperoxide reductase 1 (Ahp1p) is a thioredoxin peroxidase of the peroxiredoxin family expressed by Saccharomyces cerevisiae. Recently, disruption of the AHP1 gene has shown that the gene is not essential for yeast growth on glucose medium but revealed a high sensitivity of null mutants to organic peroxides, ...

journal_title：Toxicology letters

authors： Nguyên-nhu NT,Knoops B

更新日期：2002-10-05 00:00:00

abstract：:Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

journal_title：Toxicology letters

authors： Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

更新日期：2016-02-03 00:00:00

abstract：:Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...

journal_title：Toxicology letters

authors： Trombetta D,Mondello MR,Cimino F,Cristani M,Pergolizzi S,Saija A

更新日期：2005-12-15 00:00:00

abstract：:The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antid...

journal_title：Toxicology letters

authors： Achanta S,Chintagari NR,Brackmann M,Balakrishna S,Jordt SE

更新日期：2018-09-01 00:00:00

abstract：:The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

journal_title：Toxicology letters

authors： Morton DM

更新日期：1998-12-28 00:00:00

abstract：:The main objective of this work was to assess the potentiality of in vitro models to study and understand the uranium-induced cytotoxicity on renal cells. Cytotoxicity and morphological studies were performed in a tubular proximal original established cell line (LLC-PK1 cell line). Dose-dependent cytotoxicity response...

journal_title：Toxicology letters

authors： Mirto H,Hengé-Napoli MH,Gibert R,Ansoborlo E,Fournier M,Cambar J

更新日期：1999-02-22 00:00:00

abstract：:Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...

journal_title：Toxicology letters

authors： Sutjarit S,Nakayama SM,Ikenaka Y,Ishizuka M,Banlunara W,Rerkamnuaychoke W,Kumagai S,Poapolathep A

更新日期：2014-08-17 00:00:00

abstract：:The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseas...

journal_title：Toxicology letters

authors： Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy B

更新日期：2001-03-31 00:00:00

abstract：:Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...

journal_title：Toxicology letters

authors： Jaiswal PK,Srivastava S,Gupta J,Thakur IS

更新日期：2012-10-17 00:00:00

abstract：:Morphological malformations induced by tributyltin (TBT) exposure during embryonic development have already been characterized in various taxonomic groups, but, nonetheless, the molecular processes underlying these changes remain obscure. The present study provides the first genome-wide screening for differentially ex...

journal_title：Toxicology letters

authors： Scheider J,Afonso-Grunz F,Jessl L,Hoffmeier K,Winter P,Oehlmann J

更新日期：2018-03-01 00:00:00

abstract：:The effect of endotoxin pretreatment (1 mg/kg body weight, i.p., once daily for 2 days) on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine has been studied in albino rats. When given alone, endotoxin did not produce any visibly discernible gastric lesions. It produced a significant augmenta...

journal_title：Toxicology letters

authors： Tariq M

更新日期：1987-06-01 00:00:00

abstract：:Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...

journal_title：Toxicology letters

authors： Winder C

更新日期：2002-03-10 00:00:00

abstract：:Sulfur mustard (SM) is a highly toxic chemical warfare agent, which produces blisters after skin contact. Treatment of SM-induced adverse health effects, such as cutaneous blistering, ulceration, and inflammation remains a challenging task. Antidotes or specific therapeutic measures are lacking. Some drugs (e.g. cyclo...

journal_title：Toxicology letters

authors： Wagner S,Lang S,Popp T,Schmidt A,Thiermann H,Steinritz D,Kehe K

更新日期：2019-09-15 00:00:00

abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...

journal_title：Toxicology letters

authors： Jaurand MC,Magne L,Bignon J

更新日期：1983-02-01 00:00:00

abstract：:To investigate mechanisms of neuronal cell death in response to chlorpyrifos (CPF), a pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH-SY5Y cells treated with CPF. CPF treatment produced cytotoxic effects that appeared to involve an increase in ROS. In addition, CPF treatment activated...

journal_title：Toxicology letters

authors： Ki YW,Park JH,Lee JE,Shin IC,Koh HC

更新日期：2013-04-26 00:00:00

abstract：:Single doses of primaquine did not produce methemoglobinemia in beagle bitches. Repeated daily administration for 12 days produced a gradually rising level of methemoglobin over that time period, unaccompanied by depletion of erythrocytic reduced glutathione. Primaquine was mutagenic in the Ames test in Salmonella typ...

journal_title：Toxicology letters

authors： Marrs TC,Bright JE,Morris BC

更新日期：1987-05-01 00:00:00

abstract：:The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

journal_title：Toxicology letters

authors： Ohhira S,Matsui H,Watanabe K

更新日期：2000-11-20 00:00:00

abstract：:The lethal effects of d-amphetamine and phencyclidine (PCP) were compared when adult male mice were placed into isolated or aggregated (12 mice/cage) conditions. The LD50 of d-amphetamine decreased approx. 30-fold between isolated (87.9 mg/kg) and aggregated (2.8 mg/kg) conditions. In contrast, PCP showed only a 1.3-f...

journal_title：Toxicology letters

authors： Landauer MR,Balster RL

更新日期：1982-07-01 00:00:00

abstract：:Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

journal_title：Toxicology letters

authors： Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

更新日期：2014-04-07 00:00:00

abstract：:In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...

journal_title：Toxicology letters

authors： Leng G,Lewalter J

更新日期：2002-08-05 00:00:00