Guanidinoacetic acid (GAA) synthesis in rat tubular suspension as a system for evaluating gentamicin (GM) nephrotoxicity.


:Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA synthesis was significantly suppressed with 1 mM GM; (2) GM-induced decrease in GAA synthesis was recognized during incubation longer than 15 min; (3) furosemide significantly enhanced the suppression of GAA synthesis by GM. The results obtained parallel with those in the whole animal thus making GAA synthesis in tubular suspension a valid system for evaluating the GM-induced proximal tubular damage.


Toxicol Lett


Toxicology letters


Takeda M,Jung KY,Sekine T,Endou H,Koide H




Has Abstract


1995-11-15 00:00:00














  • Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE).

    abstract::When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Gearhart JM,Mahle DA,Greene RJ,Seckel CS,Flemming CD,Fisher JW,Clewell HJ 3rd

    更新日期:1993-05-01 00:00:00

  • Inhibition of human and rat 11β-hydroxysteroid dehydrogenases activities by bisphenol A.

    abstract::Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it can interfere with steroid biosynthesis and metabolism. However, the mechanism is unclear. The objective of the present study is to investigate the effects of BPA on two isoforms of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2)...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Guo J,Yuan X,Qiu L,Zhu W,Wang C,Hu G,Chu Y,Ye L,Xu Y,Ge RS

    更新日期:2012-11-30 00:00:00

  • Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behaviour in male mice.

    abstract::Numerous chemicals released into the environment by man are able to disrupt the functioning of the endocrine system by binding to estrogen receptors in estrogen-responsive cells. The ability of o,p'-dichlorodiphenyl trichloroethane (DDT) and methoxychlor to compete with estradiol for binding to estrogen receptors in M...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: vom Saal FS,Nagel SC,Palanza P,Boechler M,Parmigiani S,Welshons WV

    更新日期:1995-05-01 00:00:00

  • Effect of vitamin C on acute paracetamol poisoning.

    abstract::The effects of vitamin C on acute paracetamol poisoning were studied in mice. Given orally at 50, 100 or 200 mg/kg, either simultaneously or 2 h after the oral administration of 875 mg/kg of paracetamol, vitamin C did not cause any decrease in the mortality rate. In similar conditions in previous experiments methionin...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Romero-Ferret C,Mottot G,Legros J,Margetts G

    更新日期:1983-08-01 00:00:00

  • Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model.

    abstract::Clinical epidemiological studies have shown that there is a link between Parkinson's disease (PD) and cancer, but how PD regulates cancer development remains unknown. In our study, the effect of metabotropic glutamate receptor 5 (mGlu5) on hepatoma was explored in a rotenone-induced PD model both in vitro and in vivo....

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Bai XX,Gu L,Yang HM,Xi SS,Xia N,Zhang S,Zhang H

    更新日期:2018-05-15 00:00:00

  • Role of NADPH oxidase in cooperative reactive oxygen species generation in dopaminergic neurons induced by combined treatment with dieldrin and lindane.

    abstract::Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative tox...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sharma H,Hirko AC,King MA,Liu B

    更新日期:2018-12-15 00:00:00

  • The mutagenicity of urine fractions from patients administered antineoplastic therapy.

    abstract::A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Monteith DK,Connor TH,Benvenuto JA,Fairchild EJ,Theiss JC

    更新日期:1988-03-01 00:00:00

  • Correlation of liver tumor morphology and weight to incidence of pulmonary metastases in the mouse.

    abstract::Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

    更新日期:1980-12-01 00:00:00

  • Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests.

    abstract::Several in vivo and in vitro studies have assessed methods of evaluating the cardio toxicity of compounds during drug development due to its importance for predicting human toxicity. However, in vivo/in vitro relationships have not yet been reported using a zebrafish model. This study determined the bradycardia of 15 ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Park MJ,Lee KR,Shin DS,Chun HS,Kim CH,Ahn SH,Bae MA

    更新日期:2013-01-10 00:00:00

  • Hemoglobin adducts as biomarkers of estrogen homeostasis: elevation of estrogenquinones as a risk factor for developing breast cancer in Taiwanese women.

    abstract::The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

    更新日期:2014-03-21 00:00:00

  • Alkyl hydroperoxide reductase 1 protects Saccharomyces cerevisiae against metal ion toxicity and glutathione depletion.

    abstract::Alkyl hydroperoxide reductase 1 (Ahp1p) is a thioredoxin peroxidase of the peroxiredoxin family expressed by Saccharomyces cerevisiae. Recently, disruption of the AHP1 gene has shown that the gene is not essential for yeast growth on glucose medium but revealed a high sensitivity of null mutants to organic peroxides, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nguyên-nhu NT,Knoops B

    更新日期:2002-10-05 00:00:00

  • Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test.

    abstract::Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

    更新日期:2016-02-03 00:00:00

  • Toxic effect of nickel in an in vitro model of human oral epithelium.

    abstract::Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Trombetta D,Mondello MR,Cimino F,Cristani M,Pergolizzi S,Saija A

    更新日期:2005-12-15 00:00:00

  • TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.

    abstract::The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antid...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Achanta S,Chintagari NR,Brackmann M,Balakrishna S,Jordt SE

    更新日期:2018-09-01 00:00:00

  • Importance of species selection in drug toxicity testing.

    abstract::The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Morton DM

    更新日期:1998-12-28 00:00:00

  • Intracellular behaviour of uranium(VI) on renal epithelial cell in culture (LLC-PK1): influence of uranium speciation.

    abstract::The main objective of this work was to assess the potentiality of in vitro models to study and understand the uranium-induced cytotoxicity on renal cells. Cytotoxicity and morphological studies were performed in a tubular proximal original established cell line (LLC-PK1 cell line). Dose-dependent cytotoxicity response...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Mirto H,Hengé-Napoli MH,Gibert R,Ansoborlo E,Fournier M,Cambar J

    更新日期:1999-02-22 00:00:00

  • Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice.

    abstract::Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sutjarit S,Nakayama SM,Ikenaka Y,Ishizuka M,Banlunara W,Rerkamnuaychoke W,Kumagai S,Poapolathep A

    更新日期:2014-08-17 00:00:00

  • Role of inflammation in chemical-induced hepatotoxicity.

    abstract::The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseas...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy B

    更新日期:2001-03-31 00:00:00

  • Dibenzofuran induces oxidative stress, disruption of trans-mitochondrial membrane potential (ΔΨm) and G1 arrest in human hepatoma cell line.

    abstract::Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jaiswal PK,Srivastava S,Gupta J,Thakur IS

    更新日期:2012-10-17 00:00:00

  • Morphological and transcriptomic effects of endocrine modulators on the gonadal differentiation of chicken embryos: The case of tributyltin (TBT).

    abstract::Morphological malformations induced by tributyltin (TBT) exposure during embryonic development have already been characterized in various taxonomic groups, but, nonetheless, the molecular processes underlying these changes remain obscure. The present study provides the first genome-wide screening for differentially ex...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Scheider J,Afonso-Grunz F,Jessl L,Hoffmeier K,Winter P,Oehlmann J

    更新日期:2018-03-01 00:00:00

  • Effect of a low-dose endotoxin pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine in rats.

    abstract::The effect of endotoxin pretreatment (1 mg/kg body weight, i.p., once daily for 2 days) on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine has been studied in albino rats. When given alone, endotoxin did not produce any visibly discernible gastric lesions. It produced a significant augmenta...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tariq M

    更新日期:1987-06-01 00:00:00

  • Mechanisms of multiple chemical sensitivity.

    abstract::Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Winder C

    更新日期:2002-03-10 00:00:00

  • Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes.

    abstract::Sulfur mustard (SM) is a highly toxic chemical warfare agent, which produces blisters after skin contact. Treatment of SM-induced adverse health effects, such as cutaneous blistering, ulceration, and inflammation remains a challenging task. Antidotes or specific therapeutic measures are lacking. Some drugs (e.g. cyclo...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wagner S,Lang S,Popp T,Schmidt A,Thiermann H,Steinritz D,Kehe K

    更新日期:2019-09-15 00:00:00

  • Mechanism of haemolysis by chrysotile fibres.

    abstract::Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jaurand MC,Magne L,Bignon J

    更新日期:1983-02-01 00:00:00

  • JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis.

    abstract::To investigate mechanisms of neuronal cell death in response to chlorpyrifos (CPF), a pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH-SY5Y cells treated with CPF. CPF treatment produced cytotoxic effects that appeared to involve an increase in ROS. In addition, CPF treatment activated...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ki YW,Park JH,Lee JE,Shin IC,Koh HC

    更新日期:2013-04-26 00:00:00

  • Methemoglobinogenic potential of primaquine and its mutagenicity in the Ames test.

    abstract::Single doses of primaquine did not produce methemoglobinemia in beagle bitches. Repeated daily administration for 12 days produced a gradually rising level of methemoglobin over that time period, unaccompanied by depletion of erythrocytic reduced glutathione. Primaquine was mutagenic in the Ames test in Salmonella typ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Marrs TC,Bright JE,Morris BC

    更新日期:1987-05-01 00:00:00

  • Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice.

    abstract::The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ohhira S,Matsui H,Watanabe K

    更新日期:2000-11-20 00:00:00

  • The effects of aggregation on the lethality of phencyclidine in mice.

    abstract::The lethal effects of d-amphetamine and phencyclidine (PCP) were compared when adult male mice were placed into isolated or aggregated (12 mice/cage) conditions. The LD50 of d-amphetamine decreased approx. 30-fold between isolated (87.9 mg/kg) and aggregated (2.8 mg/kg) conditions. In contrast, PCP showed only a 1.3-f...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Landauer MR,Balster RL

    更新日期:1982-07-01 00:00:00

  • Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles.

    abstract::Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

    更新日期:2014-04-07 00:00:00

  • Polymorphism of glutathione S-transferases and susceptibility to acrylonitrile and dimethylsulfate in cases of intoxication.

    abstract::In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Leng G,Lewalter J

    更新日期:2002-08-05 00:00:00