Abstract：
:The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We report the biodistribution of titanium in healthy young adults (12-13-week-old) and in elderly rats (19-month-old) exposed to 10mg/m3 of a TiO2 nanostructured aerosol 6h/day, 5days/week for 4 weeks. We measured Ti content in major organs using inductively coupled plasma mass spectrometry immediately and up to 180days after the end of exposure. Large amounts of titanium were initially found in lung which were slowly cleared during the post-exposure period. From day 28, a small increase of Ti was found in the spleen and liver of exposed young adult rats. Such an increase was however never found in their blood, kidneys or brain. In the elderly group, translocation to extra-pulmonary organs was significant at day 90. Ti recovered from the spleen and liver of exposed elderly rats was higher than in exposed young adults. These data suggest that TiO2 NPs may translocate from the lung to extra-pulmonary organs where they could possibly promote systemic health effects.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo Adoi
10.1016/j.toxlet.2016.11.009subject
Has Abstractpub_date
2017-01-04 00:00:00pages
61-69eissn
0378-4274issn
1879-3169pii
S0378-4274(16)33303-3journal_volume
265pub_type
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