Abstract:
:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of litters, litter size, pup weight and litter weight. The body weight of pups during the lactation period in the treatment groups increased less significantly, and the survival index at postnatal day (PND) 21 of the amaranth 0.27% group was reduced. Developmental parameters, direction of swimming on PND 4 in male pups and olfactory orientation in each sex were significantly reduced in the treatment groups. The dose levels of amaranth in this study influenced some reproductive, developmental and behavioral parameters in mice.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Tanaka Tdoi
10.1016/0378-4274(92)90290-zkeywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
315-24issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(92)90290-Zjournal_volume
60pub_type
杂志文章abstract::Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2011-01-15 00:00:00
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更新日期:1989-05-01 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(98)00334-8
更新日期:1998-12-28 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(86)90151-7
更新日期:1986-11-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1992-12-01 00:00:00
abstract::In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.09.014
更新日期:2019-11-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90140-8
更新日期:1987-08-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.02.007
更新日期:2019-05-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/j.toxlet.2004.04.045
更新日期:2004-10-10 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.08.016
更新日期:2008-11-10 00:00:00
abstract::Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including nerves associated with the auditory system. Based...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.07.903
更新日期:2017-09-05 00:00:00
abstract::We investigated the effect of copper on cadmium-induced cytotoxicity on vascular endothelial cells from bovine aorta in a culture system. Cytotoxicity was evaluated by the [3H]adenine release assay and the histological observation. After a 24-h incubation, cadmium exhibited a significant cytotoxicity on confluent cult...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(92)90103-q
更新日期:1992-10-01 00:00:00
abstract::Safety assessment procedures still rely heavily if not exclusively on the results of tests carried out in laboratory animals, then extrapolated to man. There are few examples of environmental compounds examined extensively enough in both man and animals to permit a critical comparison of the accuracy of such risk asse...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(92)90236-d
更新日期:1992-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:2018-01-05 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.10.010
更新日期:2016-02-26 00:00:00
abstract::Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.02.003
更新日期:2010-05-04 00:00:00
abstract::Ebselen is a seleno-organic compound that causes cell death in several cancer cell types. The mechanisms underlying its deleterious effects have not been fully elucidated. In this study, the effects of ebselen (1 μM-40 μM) on AR42J tumor cells have been examined. Cell viability was studied using AlamarBlue(®) test. Ce...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.07.025
更新日期:2014-09-17 00:00:00
abstract::Blood lead concentrations (Pb-B, microgram/100 ml) was measured in children and adults, both sexes, living in and around Liège (control group, n = 859) and in the urban center of Verviers (exposed group, n = 568) where houses with lead piping are supplied with corrosive drinking water. In control children, the mean Pb...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90077-1
更新日期:1981-01-01 00:00:00
abstract::Interstitial pulmonary fibrosis is characterized by an abnormal accumulation of fibroblasts with a resultant increase in lung collagen content. Previous research has implied a possible involvement of the T-lymphocyte in this process. We used cyclosporin A (Cy A), a known immunosuppressant, to deplete T-lymphocyte-depe...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(85)90162-6
更新日期:1985-08-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(93)90066-7
更新日期:1993-04-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(88)90003-3
更新日期:1988-04-01 00:00:00
abstract::Many studies have linked ambient fine particulate matter (aerodynamic diameters less than 2.5 μm, PM₂.₅) air pollution to increased morbidity and mortality of cardiovascular diseases in the general population, but the biologic mechanisms of these associations are yet to be elucidated. In this study, we aimed to evalua...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.05.014
更新日期:2012-07-20 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2006.08.020
更新日期:2007-02-28 00:00:00