Abstract：
:Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cells was investigated. In cell viability assays and cell proliferation assays, kahweol exhibited anti-proliferative and pro-apoptotic effects on A549 cells in a time- and dose-dependent manner. Kahweol considerably inhibited the expression of Bcl-2 but increased that of Bax; it also stimulated the cleavage of caspase-3 and PARP (poly ADP-ribose polymerase). In addition, kahweol-induced apoptosis was confirmed by TUNEL assays. Furthermore, kahweol inhibited dose-dependent phosphorylation of signal transducer and activator of transcription 3 (STAT3). An overexpression in STAT3 led to resistance to kahweol-induced apoptosis, suggesting that STAT3 was a critical target of kahweol. These findings suggest that kahweol inhibited A549 cell growth and induced apoptosis via down-regulation of STAT3 signaling pathway.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kim HG,Hwang YP,Jeong HGdoi
10.1016/j.toxlet.2009.01.022subject
Has Abstractpub_date
2009-05-22 00:00:00pages
28-34issue
1eissn
0378-4274issn
1879-3169pii
S0378-4274(09)00052-6journal_volume
187pub_type
杂志文章abstract：:The effect of paraquat on lung subcellular calcium transport was studied in male Sprague-Dawley rats. With a high dose of 30 mg/kg given i.p., a significant decrease in the lung mitochondrial and microsomal calcium uptake at 24, 48, and 72 h after paraquat was observed. Trend of recovery was evident at 96 h in the sur...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90117-8
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVES:Determine uptake of furan, a potential human carcinogen, in waterpipe tobacco (WPT) smokers in home settings. METHODS:We analysed data from a US convenience sample of 50 exclusive WPT smokers, mean age 25.3 years, and 25 non-smokers, mean age 25.5 years. For WPT smokers, data were collected at a home visit ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2020.08.002
更新日期：2020-10-15 00:00:00
abstract：:Adrenal weight and the concentration of corticosterone and glucose in plasma of male Wistar rats, dosed orally with fenitrothion (7.25 or 14.5 mg/kg/day) for 28 days were investigated. A significant increase in the relative weight of adrenals was observed 2 weeks after treatment commenced, but was preceded by an incre...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90126-6
更新日期：1982-04-01 00:00:00
abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(90)90185-o
更新日期：1990-12-01 00:00:00
abstract：:The distribution of 54Mn in various organs of pregnant rats and of their 19-day-old fetuses and in non-pregnant female rats of various ages has been studied 18 h after an i.v. injection of 54MnCl2. The results indicate that early neonates are more susceptible to manganese (Mn) than the growing rats. The localization o...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90026-0
更新日期：1980-05-01 00:00:00
abstract：:This study aims to determine whether quercetin elicits a protective effect against the toxicity of chronic exposure to low-level DDVP using metabonomic technology. Rats were randomly assigned into the control, DDVP-treated, quercetin-treated, and quercetin plus DDVP-treated groups. DDVP and quercetin were given to rat...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.12.017
更新日期：2014-03-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.05.007
更新日期：2013-07-31 00:00:00
abstract：:Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative biochemical, pathologic and...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(95)03409-9
更新日期：1995-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.03.006
更新日期：2005-07-04 00:00:00
abstract：:Ursolic acid (UA), a pentacyclic triterpene acid, is reported to have inducing activity of hepatic metallothionein (MT) which responsible for the detoxification of heavy metals; however, the mechanism underlying its effects is poorly understood. To further determine the underlying mechanism of UA, this study investiga...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.11.002
更新日期：2005-03-15 00:00:00
abstract：:Reactivity of phenoxyl radicals towards biomolecules (proteins, nucleic acids and lipids) is essential for antioxidant (protective) versus prooxidant (cytotoxic) effects of phenolic compounds (antioxidants, phytochemicals, environmental pollutants and toxic chemicals). The present study demonstrates for the first time...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03767-8
更新日期：1996-10-01 00:00:00
abstract：:Alternaria spp. are ubiquitous molds that are able to produce toxic secondary metabolites which may contaminate food globally. One of those is the mycotoxin altertoxin II (ATX-II), a genotoxic and mutagenic compound. In recent years, different flavonoids that may co-occur with mycotoxins in food were demonstrated to t...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.12.002
更新日期：2018-03-01 00:00:00
abstract：:Early life exposure to certain kinds of chemicals is of concern because of a possible increase in cancer risk, but relevant data are limited. In the present experiment, modifying effects of prepubertal administration of potassium perchlorate (KClO(4)) and tetrabromobisphenol A (TBBPA) on susceptibility to multi-organ ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.12.013
更新日期：2009-03-28 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,多中心研究
doi：10.1016/j.toxlet.2013.04.008
更新日期：2013-06-20 00:00:00
abstract：:Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-Dawley (SD) rats were used to establish animal models...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.12.004
更新日期：2017-01-15 00:00:00
abstract：:To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most imp...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.04.002
更新日期：2012-08-13 00:00:00
abstract：:The aim of this study was to investigate the oxidative effects of Fe(2)O(3), benzo(a)pyrene (B(a)P) and pyrene, alone or in association (B(a)P or pyrene coated onto Fe(2)O(3) particles), in normal human embryonic lung epithelial cells (L132) in culture. We evaluated: (i) membrane integrity, through fatty acid release ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(00)00231-9
更新日期：2000-09-30 00:00:00
abstract：:In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.04.031
更新日期：2009-11-12 00:00:00
abstract：:Since a number of food and food products contain 2,4-hexadienal (HX), an unsaturated aldehyde, human exposure to HX is likely. Long term HX feeding to rodents induces forestomach cancers. Aldehyde dehydrogenases (ALDH) are key enzymes in the stomach for the metabolism of aldehydes. We examined the effect of short term...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(02)00334-x
更新日期：2003-01-13 00:00:00
abstract：:Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90057-6
更新日期：1981-02-01 00:00:00
abstract：:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03637-5
更新日期：1996-04-01 00:00:00
abstract：:Dysregulated cell proliferation and tumorigenesis is frequently encountered in several cancers including hepatocellular carcinogenesis (HCC). Thus, agents that inhibit cell proliferation and restrain hepatic tumorigenesis through cell cycle regulation have a beneficial effect in the treatment of hepatocellular carcino...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.08.018
更新日期：2013-10-23 00:00:00
abstract：:Over the last twenty years research has provided an important insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of immunostimulating drugs and adjuvants. In this article we provide an update of the present knowledge relating to the various par...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2011.03.001
更新日期：2011-06-10 00:00:00
abstract：:PFAS are man-made compounds that are highly spread in the environment. Human dietary exposure to such contaminants is of high concern as they may accumulate in the food chain. Different studies already demonstrated the importance of the fish consumption in the dietary exposure of these molecules and the potential incr...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.07.028
更新日期：2014-12-01 00:00:00
abstract：:There have been many concerns about the possible adverse effects of thyroid hormone-disrupting chemicals in the environment. Because thyroid hormones are essential for regulating the growth and differentiation of many tissues, disruption of thyroid hormones during the neonatal period of an organism might lead to perma...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.01.005
更新日期：2018-04-01 00:00:00
abstract：:Drug-induced liver injury (DILI) is a major problem in drug development. Although some in vitro methods assessing DILI risk that utilize hepatic cell death or cellular stress as markers have been developed, the predictive ability of these tests is low. In this study, we sought to develop a novel cell-based assay for t...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.10.029
更新日期：2016-01-22 00:00:00
abstract：:The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90163-6
更新日期：1981-11-01 00:00:00
abstract：:Dimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing at the forefront. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. Therefore, the aim of the presented study was to determine the human NAT and ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.11.033
更新日期：2014-02-10 00:00:00
abstract：:Morusin is a prenylated flavonoid that has been isolated from the root bark of the mulberry tree (Morus species, Moraceae), a Chinese traditional medicine. It has been synthesized by our laboratory from commercially available phloroglucinol, and has demonstrated to possess antitumor effects of cell lines including A54...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.11.031
更新日期：2015-01-22 00:00:00
abstract：:Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effect...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90003-3
更新日期：1988-04-01 00:00:00
