当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > Differential mechanisms of action are involved in chlorpyrifos effects in estrogen-dependent or -independent breast cancer cells exposed to low or high concentrations of the pesticide.

Differential mechanisms of action are involved in chlorpyrifos effects in estrogen-dependent or -independent breast cancer cells exposed to low or high concentrations of the pesticide.

Abstract：

:It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action employing MCF-7 and MDA-MB-231 breast cancer cell lines. We have also analyzed CPF action on the cell cycle distribution and the cyclins that are implicated in G1-S and intra-S checkpoints. Finally, the action on cell death and ROS production were studied. We demonstrated the ability of CPF 0.05μM to induce cell proliferation through ERα in hormone-dependent breast cancer cells. In contrast, CPF 50μM induces intra-S arrest modifying checkpoints proteins, through a mechanism that may involve changes in redox balance in MCF-7. In MDA-MB-231, we have found that CPF 50μM produces an arrest in G2/M phase which could be related to the capacity of the pesticide for binding to tubulin sites altering microtubules polymerization. Altogether, our results provide new evidences on the action of the pesticide CPF as an environmental breast cancer risk factor due to the effects that causes on the mechanisms that modulate breast cell proliferation.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

doi

10.1016/j.toxlet.2012.06.017

subject

Has Abstract

pub_date

2012-09-03 00:00:00

pages

184-93

issue

2

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(12)01188-5

journal_volume

213

pub_type

杂志文章

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