Abstract：
:Cultured human proximal tubule cell monolayers maintained on permeable supports were treated simultaneously with the aminoglycoside antibiotic, gentamicin, and poly-L-aspartic acid (PAA), an inhibitor of aminoglycoside nephrotoxicity. Following 4 days of exposure, cell monolayers were placed into Ussing chambers to allow monitoring of transepithelial electrical properties. For each of the three cell isolates examined, aminoglycoside-induced alterations in electrogenic transport, reflected by changes in short-circuit current (Isc), as well as alterations in paracellular properties, indicated by changes in transepithelial electrical resistance (RT), were diminished in the presence of PAA. Alterations resulting from selective basolateral exposure to gentamicin were unchanged in the case of apically applied PAA and attenuated only when PAA acid was added basolaterally. This is the first demonstration of PAA inhibition of aminoglycoside-induced cellular alterations involving human cells.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Todd JH,Hottendorf GHdoi
10.1016/s0378-4274(96)03858-1subject
Has Abstractpub_date
1997-02-07 00:00:00pages
217-21issue
2-3eissn
0378-4274issn
1879-3169pii
S0378-4274(96)03858-1journal_volume
90pub_type
杂志文章abstract：:Neurobehavioral effects of polychlorinated biphenyls (PCBs) at environmental levels of exposure have been reported in cross-sectional and prospective studies in infants and children. However, observations differ for effect spectrum, persistence and effective matrix (cord plasma, maternal plasma or milk). In order to i...
journal_title：Toxicology letters
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更新日期：1998-12-28 00:00:00
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journal_title：Toxicology letters
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更新日期：2015-01-22 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.05.015
更新日期：2016-07-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2011-06-24 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2012-05-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2008-01-04 00:00:00
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journal_title：Toxicology letters
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更新日期：1998-12-28 00:00:00
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journal_title：Toxicology letters
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更新日期：2003-02-18 00:00:00
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journal_title：Toxicology letters
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更新日期：2002-02-07 00:00:00
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journal_title：Toxicology letters
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更新日期：1990-02-01 00:00:00
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journal_title：Toxicology letters
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doi：10.1016/j.toxlet.2011.04.010
更新日期：2011-09-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.06.015
更新日期：2010-10-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1998-01-16 00:00:00
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journal_title：Toxicology letters
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更新日期：1991-08-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2008-11-10 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章,多中心研究
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更新日期：2008-01-04 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2011-02-25 00:00:00
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journal_title：Toxicology letters
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更新日期：1982-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2000-04-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1991-04-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1997-07-21 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.08.014
更新日期：2016-11-30 00:00:00
abstract：:The oral LD50 of hymenoxon in Swiss white mice was found to be 241 +/- 37 mg/kg. No significant sex differences were observed. Pretreatment of male mice for 3 days using doses of 50 and 100 mg/kg hymenoxon failed to alter significantly pentobarbital sleeping time. Hymenoxon was found to be a direct-acting mutagen in t...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90016-3
更新日期：1981-12-01 00:00:00
abstract：:The aim of this study is to predict dermal permeability of four phenolic biocides in four different formulations using a linear solvation energy relationship (LSER) approach, with a calibrated flow through diffusion cell system. Mathematical descriptors were determined in the laboratory, by mathematical computations, ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.09.005
更新日期：2007-12-10 00:00:00
