Abstract:
:Inhalation of ultrafine particulate matter (PM) in air pollution increases cardiovascular mortality by passing into systemic circulation and possibly affecting endothelial cell (EC) function. This study identified the chemical constituents, including polycyclic aromatic hydrocarbons (PAHs), in diesel exhaust particulate extracts (DEPEs) prepared from a truck run at different speeds and engine loads. The short-term effects of DEPEs alone or in combination with estradiol (E(2)) on MAPK (ERK1/2), AKT, and eNOS activation and nitric oxide (NO) production in human umbilical vein EC (HUVEC) were evaluated. Notably, DEPE from a truck run under increasing loads (L) stimulated phosphorylation of MAPK, AKT, and eNOS whereas DEPE from the truck run at increasing speeds (S) did not affect MAPK alone, but inhibited E(2)-induced MAPK and eNOS phosphorylation. Higher PAH concentrations in the DEPE L versus DEPE S samples correlate with the observed differences in cellular activities. Like E(2), DEPEs rapidly increased NO with the DEPE L sample acting additively with E(2) and then inhibiting E(2)-induced NO with longer treatment time. Like E(2), DEPEs increased trans-endothelial electrical resistance (TEER) across a monolayer of HUVEC. These data are the first characterization of rapid effects of DEPE in human EC and may indicate mechanisms for diesel exhaust in vascular function.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Sumanasekera WK,Ivanova MM,Johnston BJ,Dougherty SM,Sumanasekera GU,Myers SR,Ali Y,Kizu R,Klinge CMdoi
10.1016/j.toxlet.2007.08.014subject
Has Abstractpub_date
2007-11-01 00:00:00pages
61-73issue
1-3eissn
0378-4274issn
1879-3169pii
S0378-4274(07)00922-8journal_volume
174pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:2013-09-12 00:00:00
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2006.08.012
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.10.028
更新日期:2009-01-30 00:00:00
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pub_type: 共识发展会议,杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2004-04-21 00:00:00
abstract::Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2013-06-07 00:00:00
abstract::Bisphenol A (BPA) has one of the highest production volumes of all chemicals worldwide. It has been widely studied because of its endocrine modulating activity. In addition to dietary intake, absorption of BPA via the skin from handling thermal papers is believed to be a relevant route of exposure. We studied BPA expo...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.08.020
更新日期:2014-11-04 00:00:00
abstract:BACKGROUND:The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosi...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.02.014
更新日期:2019-06-01 00:00:00