Abstract:
:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholic aortas to agonists were comparable. NS and AS induced contractions on normal aorta, but the responses of alcoholic aortas were lower; contractions induced by AS on both aortas were larger than those induced by NS. AS decreased verapamil-induced relaxation more than NS. A pressor circulating factor might be responsible.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Baños G,Lopez-Zetina P,Franco Mdoi
10.1016/0378-4274(94)03180-0subject
Has Abstractpub_date
1995-02-01 00:00:00pages
1-9issue
1eissn
0378-4274issn
1879-3169pii
0378-4274(94)03180-0journal_volume
76pub_type
杂志文章abstract::Dopaminergic system dysfunction is proved to be a possible mechanism in acrylamide (ACR) -induced neurotoxicity. The neurotransmitter dopamine (DA) has an increasingly important role in the dopaminergic system. Thus, the goal of this study is to evaluate effects of ACR on dopamine and its metabolite levels, dopamine t...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2012.09.020
更新日期:2012-11-23 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:1998-11-23 00:00:00
abstract::Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. These findings provoked the present in vitro study which was designed to determine the inhibition, aging, spontaneou...
journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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abstract::Primary cultures of rat hepatocytes were exposed to 3 or 30 microM stable cadmium (Cd) in the presence or absence of 1.8 or 3.6 mM calcium (Ca). The presence of Ca significantly reduced the efflux of lactate dehydrogenase (LDH) from cells regardless of Cd concentration or exposure time. During a 3-h time interval, the...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2015.09.014
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:2020-05-15 00:00:00