A vasoactive serum component and reactivity of isolated rat aorta after chronic alcohol administration.

Abstract:

:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholic aortas to agonists were comparable. NS and AS induced contractions on normal aorta, but the responses of alcoholic aortas were lower; contractions induced by AS on both aortas were larger than those induced by NS. AS decreased verapamil-induced relaxation more than NS. A pressor circulating factor might be responsible.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Baños G,Lopez-Zetina P,Franco M

doi

10.1016/0378-4274(94)03180-0

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

1-9

issue

1

eissn

0378-4274

issn

1879-3169

pii

0378-4274(94)03180-0

journal_volume

76

pub_type

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