Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60.

abstract：:The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effect of the OP Crotylsarin (CRS) on respir...

journal_title：Toxicology letters

authors： Klein-Rodewald T,Seeger T,Dutschmann M,Worek F,Mörschel M

更新日期：2011-09-25 00:00:00

abstract：:In male Sprague-Dawley rats, motor and sensory conduction velocities (MNCV and SNCV) of the tail nerve decreased significantly as a result of oral administration of 400 and 200 mg/kg of 2,5 hexanedione (2,5-HD) once daily, 5 days a week for up to 7 and 15 weeks, respectively; and of whole-body exposure to 300 ppm of v...

journal_title：Toxicology letters

authors： Gagnaire F,Nicot T,Zissu D,Bonnet P,de Ceaurriz J

更新日期：1986-01-01 00:00:00

abstract：:Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...

journal_title：Toxicology letters

authors： Zhou J,Geng F,Xu J,Peng L,Ye X,Yang D,Zhao J,Sun Q

更新日期：2019-11-01 00:00:00

abstract：:Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

journal_title：Toxicology letters

authors： De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

更新日期：1995-10-01 00:00:00

abstract：:EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

journal_title：Toxicology letters

authors： Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

更新日期：1984-07-01 00:00:00

abstract：:There are numerous observations of pharmaceuticals (or their metabolites) as contaminants in wastewater, surface water and groundwater. This implies a potential for indirect human exposure to pharmaceuticals via drinking water supplies. Various effect benchmarks may be employed in an evaluation of the significance of ...

journal_title：Toxicology letters

authors： Webb S,Ternes T,Gibert M,Olejniczak K

更新日期：2003-05-15 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:Little information is available upon the effects of carbon nanotubes (CNT) on the airway barrier. Here we study the barrier function of Calu-3 human airway epithelial cells, grown on permeable filters, after the exposure to commercial single-walled or multi-walled CNT, produced through chemical vapour deposition. To a...

journal_title：Toxicology letters

authors： Rotoli BM,Bussolati O,Bianchi MG,Barilli A,Balasubramanian C,Bellucci S,Bergamaschi E

更新日期：2008-05-05 00:00:00

abstract：:The proceedings in this volume suggest several important future research needs. Research is needed to validate modeling in toxicology in order to support the use of the general approach of modeling, either for structure-activity relationships (SAR) or physiologically based pharmacokinetics (PBPK), by regulators. Resea...

journal_title：Toxicology letters

authors： Menzel DB

更新日期：1995-09-01 00:00:00

abstract：:The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We re...

journal_title：Toxicology letters

authors： Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo A

更新日期：2017-01-04 00:00:00

abstract：:L-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H₂O₂), were characterized with lower l...

journal_title：Toxicology letters

authors： Lemire J,Mailloux R,Darwich R,Auger C,Appanna VD

更新日期：2011-06-24 00:00:00

abstract：:The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods ...

journal_title：Toxicology letters

authors： Hasegawa K,Miwa S,Tsutsumiuchi K,Taniguchi H,Miwa J

更新日期：2004-09-10 00:00:00

abstract：:Toluene diisocyanate (TDI), a highly reactive industrial chemical is a leading cause of occupational asthma in westernized countries. It has also been reported to be a skin sensitizer in mice and guinea pigs although instances of skin sensitivity in humans are rare. It is uncertain if skin-contact is necessary to init...

journal_title：Toxicology letters

authors： Ebino K,Ueda H,Kawakatsu H,Shutoh Y,Kosaka T,Nagayoshi E,Lemus R,Karol MH

更新日期：2001-04-08 00:00:00

abstract：:Dichloromethane (DCM) elimination and carboxyhemoglobin (COHb) generation were examined in adult female SD rats pretreated with a glutathione (GSH) depletor(s). Rats were treated with either buthionine sulfoximine (BSO; 2 mmol/kg, i.p.), diethylmaleate (DEM; 3 mmol/kg, i.p.), phorone (PHO; 1 mmol/kg, i.p.) or BSO plus...

journal_title：Toxicology letters

authors： Oh SJ,Kim SK,Kim YC

更新日期：2002-03-24 00:00:00

abstract：:When cells from the human cell line NHIK3025 were cultured for 4 days, with hexavalent chromium (K2Cr2O7) at a concentration of 8 . 10(-7)M, the relative cell number was reduced to 38%. This effect of hexavalent chromium was abolished if ascorbic acid and chromate were added simultaneously to the incubation medium, bu...

journal_title：Toxicology letters

authors： Jakobsen K,Eik-Nes KB

更新日期：1982-09-01 00:00:00

abstract：:In this study, the effects of exposure to a 900 megahertz (MHz) electromagnetic field (EMF) on serum thyroid stimulating hormone (TSH) and triiodothronine-thyroxin (T3-T4) hormones levels of adult male Sprague-Dawley rats were studied. Thirty rats were used in three independent groups, 10 of which were control (withou...

journal_title：Toxicology letters

authors： Koyu A,Cesur G,Ozguner F,Akdogan M,Mollaoglu H,Ozen S

更新日期：2005-07-04 00:00:00

abstract：:Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER). Many lines of evidence reveal that BPA has an impact as an endocrine disruptor even at low doses. However, its binding to ER and hormonal activity is extremely weak, making the intrinsic significance ...

journal_title：Toxicology letters

authors： Takayanagi S,Tokunaga T,Liu X,Okada H,Matsushima A,Shimohigashi Y

更新日期：2006-12-01 00:00:00

abstract：:Glutathione (GSH) levels, glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) as antioxidant defense system were evaluated in CHO-K1 cells after beauvericin (BEA) exposure. The effect of N-acetyl-cysteine (NAC) pre-treatment was assessed. GSH levels significantly decrease 18% a...

journal_title：Toxicology letters

authors： Mallebrera B,Font G,Ruiz MJ

更新日期：2014-05-02 00:00:00

abstract：:Effective emergency preparedness and response planning are needed to assist responders in making sound decisions under the stressful and confusing conditions accompanying a major accidental release of hazardous materials. One of the most important decisions to be made is the extent and duration of the evacuation of pe...

journal_title：Toxicology letters

authors： Wiener RK,Shaver DK

更新日期：1989-12-01 00:00:00

abstract：:Serum corticosterone levels were determined at intervals after i.p. injection of 1.8 mg cadmium (Cd)/kg body weight. Thymus weight decreased significantly 3 days after injection. The effect of Cd injection on serum corticosterone levels was almost indistinguishable from that of saline injection. Further, Cd-induced th...

journal_title：Toxicology letters

authors： Yamada YK,Murakami N,Shimizu F,Kubota K

更新日期：1982-08-01 00:00:00

abstract：:Cytochrome P4501A1 is involved in the metabolism of carcinogenic polycyclic aromatic hydrocarbons; therefore, its inhibition interferes with the carcinogenesis process induced by these compounds in rats. The human and rat CYP1A1 differ by 21% in amino acid sequence, including the active site of the enzyme; this differ...

journal_title：Toxicology letters

authors： Santes-Palacios R,Romo-Mancillas A,Camacho-Carranza R,Espinosa-Aguirre JJ

更新日期：2016-09-06 00:00:00

abstract：:Nitrogen mustard (HN-2), also known as mechlorethamine, is an alkylating anticancer agent as well as blister inducing chemical warfare agent. We evaluated the cytoprotective efficacy of amifostine, DRDE-07 and their analogues, and other antidotes of mustard agents against HN-2. Administration of 1 LD(50) of HN-2 (20mg...

journal_title：Toxicology letters

authors： Sharma M,Vijayaraghavan R,Gautam A

更新日期：2009-08-10 00:00:00

abstract：:Children may be inherently more vulnerable than adults to the lethal effects associated with chemical warfare nerve agent (CWNA) exposure because of their closer proximity to the ground, smaller body mass, higher respiratory rate, increased skin permeability and immature metabolic systems. Unfortunately, there have on...

journal_title：Toxicology letters

authors： Wright LK,Lee RB,Vincelli NM,Whalley CE,Lumley LA

更新日期：2016-01-22 00:00:00

abstract：:The aim of this study was to investigate the hepatotoxic effect and its underlying mechanism of aloe emodin (AE). AE was docked with the targets of NF-κB inflammatory pathway and P53 apoptosis pathway respectively by using molecular docking technique. To verify the results of molecular docking and further investigate ...

journal_title：Toxicology letters

authors： Quan Y,Gong L,He J,Zhou Y,Liu M,Cao Z,Li Y,Peng C

更新日期：2019-05-15 00:00:00

abstract：:288 BALB/c male mice were allocated to: Group 1-control; Group 2-500 ppm of 2-acetylaminofluorene (2-AAF) in the food, with control water; Group 4-500 ppm of 2-AAF in the food and 250 mg/100 ml of vitamin C in the water; and Group 3-control food and 250 mg% of vitamin C in the water. Major histopathologic changes at t...

journal_title：Toxicology letters

authors： Frith CH,Rule J,Kodell RL

更新日期：1980-09-01 00:00:00

abstract：:The aim of this study was to establish an air-liquid interface (ALI) culture of precision-cut lung slices (PCLS) for direct exposure of lung cells to gaseous contaminants. Nitrogen dioxide (NO(2)) and ozone (O(3)) were selected as model gas compounds. Acute pro-inflammatory and toxic effects of NO(2) and O(3) on live ...

journal_title：Toxicology letters

authors： Switalla S,Knebel J,Ritter D,Krug N,Braun A,Sewald K

更新日期：2010-07-01 00:00:00

abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

journal_title：Toxicology letters

authors： Sastry KV,Sunita K

更新日期：1983-04-01 00:00:00

abstract：:Regions with heavy industry are in many ways regions of crisis. The health of the population is primarily affected by the different air pollutants. Dust, with all its organic (dioxins and furans) and inorganic (heavy metals) contents, makes up the greatest part of the air-borne pollutants. The influence on health of e...

journal_title：Toxicology letters

authors： Marth E,Haselbacher-Marko S,Schaffler K

更新日期：1996-11-01 00:00:00

abstract：:Enzymatic activities of Na+/K+-ATPase and Mg2+ -ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to prevent and recover the CuSO4-induced inhibition. The influence of experimentally added CuSO4 and E...

journal_title：Toxicology letters

authors： Vasić V,Jovanović D,Krstić D,Nikezić G,Horvat A,Vujisić L,Nedeljković N

更新日期：1999-10-29 00:00:00

abstract：:In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat (HVF), rich in trans isomers, being found in processed foods. Studies involving IF have shown deleterious influences on the metabolic system, similarly to HVF, whereas no studies regarding its influence on the central nervous...

journal_title：Toxicology letters

authors： D'avila LF,Dias VT,Vey LT,Milanesi LH,Roversi K,Emanuelli T,Bürger ME,Trevizol F,Maurer HL

更新日期：2017-07-05 00:00:00