Abstract：
:Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, we investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult male Long-Evans rats (N = 10/dose) received a single i.p. injection of saline, 200, 400 or 800 mg/kg sulfolane. Motor activity in figure-of-eight mazes was assessed 1 h after dosing in testing rooms maintained at either 20.8 degrees C or at 32.3 degrees C. At the warm ambient temperature, sulfolane produced hypoactivity but not hypothermia. At the cooler temperature, sulfolane-induced hypoactivity was more pronounced, and rats were hypothermic. Therefore, a behavioral change could be detected at sublethal dosages of sulfolane in the absence of hypothermia.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Ruppert PH,Dyer RSdoi
10.1016/0378-4274(85)90018-9subject
Has Abstractpub_date
1985-11-01 00:00:00pages
111-6issue
2-3eissn
0378-4274issn
1879-3169pii
0378-4274(85)90018-9journal_volume
28pub_type
杂志文章abstract：:Sulphur mustard (SM) is a blistering agent that causes debilitating damage to the skin, eyes and respiratory system. In cases of severe exposure, immunodepletion can occur as well as death, due to secondary infections. The toxicity of SM is thought to be mediated in part by the alkylation of nucleic acids and proteins...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.11.009
更新日期：2012-02-25 00:00:00
abstract：:Several in vivo and in vitro studies have assessed methods of evaluating the cardio toxicity of compounds during drug development due to its importance for predicting human toxicity. However, in vivo/in vitro relationships have not yet been reported using a zebrafish model. This study determined the bradycardia of 15 ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.10.018
更新日期：2013-01-10 00:00:00
abstract：:Humans are typically exposed to mixtures of substances, whereby their bioactivity can be significantly altered by co-occurring compounds. Thus, over the last years, research on combinatory effects has gained increasing attention. In particular, several xenoestrogens have been recently reported to interact synergistica...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.10.025
更新日期：2020-02-01 00:00:00
abstract：:Cadmium specifically modify amine metabolism at the central nervous system and pituitary hormone secretions. Thus, the physiological functions controlled by these hormones can be modulated by cadmium. This xenobiotic is associated with deleterious effects on the gonadal function and with changes in the secretory patte...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(99)00159-9
更新日期：1999-11-22 00:00:00
abstract：:Fungi of the genus Alternaria infest many agricultural crops and produce numerous mycotoxins, of which altertoxin II (ATX II) is one of the most mutagenic metabolites. ATX II carries an epoxide group but the formation of DNA adducts has not been demonstrated to date. We report now that ATX II gives rise to two covalen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2020.05.018
更新日期：2020-10-01 00:00:00
abstract：:Human saliva offers a unique noninvasive approach for populational study. Purposes of this study were to investigate the feasibility of using saliva manganese (Mn) concentration as a biomarker of Mn exposure among career welders and to study the variations of Mn, copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) in ...
journal_title：Toxicology letters
pub_type： 杂志文章,多中心研究
doi：10.1016/j.toxlet.2007.10.003
更新日期：2008-01-04 00:00:00
abstract：:Triptolide (TP) is the main ingredient of Chinese herb Tripterygium wilfordii Hook f. (TWHF). Despite of its multifunction in pharmaceutics, accumulating evidences showed that TP caused obvious hepatotoxicity in clinic. The current study investigated the role of Notch1 signaling in TP-induced hepatotoxicity. Our data ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.10.024
更新日期：2019-01-01 00:00:00
abstract：:The objective of this research was to develop a mathematical description of uptake of aromatic and aliphatic hydrocarbons into the stratum corneum of human skin in vivo. A simple description based on Fick's laws of diffusion was used to predict the spatiotemporal variation of naphthalene, 1- and 2-methylnaphthalene, u...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.03.005
更新日期：2008-05-30 00:00:00
abstract：:Short-term exposure to elevated levels of particulate matter is associated with increased respiratory and cardiovascular mortality and morbidity. However, the mechanisms underlying these effects are still unclear. Recent studies have suggested that inhaled ultrafine particles are able to translocate into the bloodstre...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.09.006
更新日期：2008-01-04 00:00:00
abstract：:Cytotoxicity in terms of haemolytic potency in vitro of eight surfactants failed to correlate with in vivo rabbit eye irritancy. Ability of the same surfactants to block spontaneous contractions of mouse and rabbit isolated ileum (especially the latter), correlated better with in vivo findings in rabbit eyes. Effectiv...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90062-0
更新日期：1983-08-01 00:00:00
abstract：:Effects of isoflavones on estrogen sensitive tissues are discussed controversially. This study was designed to investigate tissue specific effects of an isoflavone exposure through different periods of life in female Wistar rats and to compare the effects of genistein (GEN) to those of mixed dietary isoflavones, GEN a...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.08.019
更新日期：2009-12-15 00:00:00
abstract：:New metabolites of styrene, three isomeric vinylphenylmercapturic acids (2-, 3-, and 4-VPMA), were recently identified by LC-ESI-MS in the urine of mice. In this study, 4-VPMA together with traces of 2- and 3-VPMA were found also in the urine of hand-lamination workers, which were exposed to styrene vapours at concent...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.06.012
更新日期：2012-09-03 00:00:00
abstract：:In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible tools for predicting the toxicity of chemicals when little or no empirical data are available. A fundamental understanding of toxicological principles has been considered an important com...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(95)03374-t
更新日期：1995-09-01 00:00:00
abstract：:Cimetidine, a widely prescribed, potent histamine H2-receptor antagonist, is unrelatedly a mild antiandrogen. Since perinatal androgens are essential for normal masculine imprinting, we wanted to determine if maternally administered cimetidine interfered with the development of the male offspring's sex-dependent, hepa...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(91)90030-a
更新日期：1991-01-01 00:00:00
abstract：:Pyrethroids, a group of insecticides with high efficiency, low toxicity and wide spectrum, are used for pest control in agriculture. Here, we administered two representative pyrethroids (cypermethrin and deltamethrin) and an equal volume of vehicle (corn oil) to the pregnant ICR mice. This study investigated the effec...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.01.019
更新日期：2018-05-01 00:00:00
abstract：:Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90057-6
更新日期：1981-02-01 00:00:00
abstract：:In order to gain basic understanding in the ecotoxicity of endocrine disrupting chemicals or EDCs (including natural chemicals and some pharmaceuticals), many international research groups are currently testing these chemicals using aquatic invertebrates. This paper discusses relevant examples to address key questions...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(02)00046-2
更新日期：2002-05-10 00:00:00
abstract：:The tobacco smoking habit interferes with the innate host defence system against infections. Recurrent infections accelerated the functional respiratory decline. The present study assessed the effects of ceftaroline on TLR2 and TLR4 and on pro-inflammatory responses in airway epithelial cells (16HBE cell line and prim...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.06.2105
更新日期：2016-09-06 00:00:00
abstract：:The main aim of the study was to identify the critical periods of susceptibility for itraconazole-mediated teratogenesis in the mouse. Pregnant ICR (CD-1) mice received a single oral administration of itraconazole at 50 mg/kg b.w., 150 mg/kg b.w. or 250 mg/kg b.w. on gestation day 8, 9, 10, 11 or 12. Control animals w...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.08.004
更新日期：2006-11-01 00:00:00
abstract：:Heart rate (HR) and body core temperature (Tco) were monitored in unanesthetized, unrestrained adult Sprague-Dawley rats following intraperitoneal administration of 0, 10, 30, or 60 mg/kg of the pesticide chlordimeform (CDM). Significant non-dose-related decreases were observed in both HR and Tco in all treated groups...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(87)90208-6
更新日期：1987-02-01 00:00:00
abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90042-9
更新日期：1980-12-01 00:00:00
abstract：:There are multiple lines of evidence showing that environmental toxicants including pesticides may contribute to neuronal cell death. Fipronil (FPN) is a phenylpyrazole insecticide that acts on insect GABA receptors. Although the action of FPN is restricted to insect neuronal or muscular transmitter systems, a few stu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.02.022
更新日期：2012-05-20 00:00:00
abstract：:The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most potent risk factor among tobacco-related carcinogens in lung cancer progression and outcomes. Although genetic mutations and chromosome instability have been detected in NNK-induced lung tumors, the oncogenic mechanisms o...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.09.019
更新日期：2017-11-05 00:00:00
abstract：:The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90137-5
更新日期：1981-04-01 00:00:00
abstract：:Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a hig...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(87)90008-7
更新日期：1987-10-01 00:00:00
abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...
journal_title：Toxicology letters
pub_type： 历史文章,杂志文章
doi：10.1016/j.toxlet.2018.04.017
更新日期：2018-09-01 00:00:00
abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(91)90142-s
更新日期：1991-07-01 00:00:00
abstract：:In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.04.031
更新日期：2009-11-12 00:00:00
abstract：:To understand the underlying mechanism for apoptosis induced by titanium dioxide nanoparticles (TNP), human airway epithelial cell line was cultured to investigate the relevant apoptosis pathways. Our results showed that the levels of reactive oxygen species and morphological apoptosis increased in a dose-dependent ma...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.03.014
更新日期：2010-06-16 00:00:00
abstract：:To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(90)90187-q
更新日期：1990-12-01 00:00:00
