Phototoxicity of coproporphyrin as a novel photodynamic therapy was enhanced by liposomalization.

abstract：:It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1993-01-01 00:00:00

abstract：:Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mea...

journal_title：Toxicology letters

authors： Talaska G,Schamer M,Bailey JR,Ali SF,Scallet AC,Slikker W Jr,Paule MG

更新日期：1992-12-01 00:00:00

abstract：:Reports on adverse health effects related to occupational exposure to toner powder are still inconclusive. Therefore, we have previously conducted an in vitro-study to characterize the genotoxic potential of three commercially available black printer toner powders in A549 lung cells. In these cell-based assays it was ...

journal_title：Toxicology letters

authors： Könczöl M,Weiß A,Gminski R,Merfort I,Mersch-Sundermann V

更新日期：2013-02-04 00:00:00

abstract：:Considering of novel biochemical modulation by some foods and beverages, we have performed screening for green tea components that have enhancing effects on doxorubicin (DOX) induced antitumor activity. Components, such as caffeine, theanine, (-)-epigallocatechin gallate (EGCG) and flavonoids have inhibitory effects o...

journal_title：Toxicology letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-04-03 00:00:00

abstract：:Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD to substrate proteins. In the human genome, 16 different genes encoding for members of this emerging family of enzymes have been identified. Know...

journal_title：Toxicology letters

authors： Meli E,Pangallo M,Baronti R,Chiarugi A,Cozzi A,Pellegrini-Giampietro DE,Moroni F

更新日期：2003-04-04 00:00:00

abstract：:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...

journal_title：Toxicology letters

authors： Tanaka T

更新日期：1992-05-01 00:00:00

abstract：:Chronic feeding of male Wistar rats with food containing hexachlorobenzene (HCB) at 17.5 mmol/kg induced elevation of serum amino-transferases and bilirubin content, increase of microsomal cytochrome P-450 concentration, and decrease of 5'-nucleotidase, K+,Na+- and Mg2+-adenosine triphosphatase activities in liver pla...

journal_title：Toxicology letters

authors： Nikolaev V,Naydenova E,Kerimova M,Dimov S,Ivanov E

更新日期：1986-09-01 00:00:00

abstract：:Exposition to cadmium (Cd) has been linked to bone metabolism alterations and occurrence of osteoporosis. Despite its known renal toxicity which indirectly disrupts bone metabolism through impairment of vitamin D synthesis, increasing evidence argues for the direct action of Cd on bone-forming osteoblasts. Indeed, acc...

journal_title：Toxicology letters

authors： Lizotte J,Abed E,Signor C,Malu DT,Cuevas J,Kevorkova O,Sanchez-Dardon J,Satoskar A,Scorza T,Jumarie C,Moreau R

更新日期：2012-12-17 00:00:00

abstract：:The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effec...

journal_title：Toxicology letters

authors： Yamamoto H,Tang HW

更新日期：1996-09-01 00:00:00

abstract：:Manganese (Mn) is an essential trace element required for normal function and development. However, exposure to this metal at elevated levels may cause manganism, a progressive neurodegenerative disorder with neurological symptoms similar to idiopathic Parkinson's disease (IPD). Elevated body burdens of Mn from exposu...

journal_title：Toxicology letters

authors： Stephenson AP,Schneider JA,Nelson BC,Atha DH,Jain A,Soliman KF,Aschner M,Mazzio E,Renee Reams R

更新日期：2013-04-26 00:00:00

abstract：:It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...

journal_title：Toxicology letters

authors： Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

更新日期：2012-09-03 00:00:00

abstract：:This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in ...

journal_title：Toxicology letters

authors： van Esch BC,van Bilsen JH,Jeurink PV,Garssen J,Penninks AH,Smit JJ,Pieters RH,Knippels LM

更新日期：2013-06-20 00:00:00

abstract：:To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total c...

journal_title：Toxicology letters

authors： Peterson A,Lewné M,Walum E

更新日期：1981-10-01 00:00:00

abstract：:The liver carcinogen N-nitrosodimethylamine (NDMA) has to be metabolically activated by specific cytochromes before it can react with cellular macromolecules (e.g. proteins or DNA). Although hepatocytes are believed to be responsible for this activation, the liver tumours originate mainly from non-parenchymal cells (N...

journal_title：Toxicology letters

authors： Frei E,Kuchenmeister F,Gliniorz R,Breuer A,Schmezer P

更新日期：2001-09-15 00:00:00

abstract：:In recent years, the detrimental effects of high iodine on intelligence are gaining tons of attention, but the relationship between high iodine and neurotoxicity is controversial. This study aimed to explore whether high iodine intake may impair intelligence and the roles of apoptosis and autophagy in high iodine-indu...

journal_title：Toxicology letters

authors： Cui Y,Zhang Z,Zhang B,Zhao L,Hou C,Zeng Q,Nie J,Yu J,Zhao Y,Gao T,Wang A,Liu H

更新日期：2018-11-01 00:00:00

abstract：:Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg(0). In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were stu...

journal_title：Toxicology letters

authors： Harari R,Harari F,Gerhardsson L,Lundh T,Skerfving S,Strömberg U,Broberg K

更新日期：2012-08-13 00:00:00

abstract：:New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection...

journal_title：Toxicology letters

authors： Richter LHJ,Herrmann J,Andreas A,Park YM,Wagmann L,Flockerzi V,Müller R,Meyer MR

更新日期：2019-05-01 00:00:00

abstract：:The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous soluti...

journal_title：Toxicology letters

authors： Baranowska-Dutkeiwicz B

更新日期：1982-03-01 00:00:00

abstract：:The prevention of renal diseases induced by chemicals requires the use of tests with which adverse renal effects can be detected at a stage when removal from exposure to the offending agent(s) may lead to complete recovery or may at least prevent an accelerated decline in renal function. The screening tests used in cl...

journal_title：Toxicology letters

authors： Lauwerys R,Bernard A

更新日期：1989-03-01 00:00:00

abstract：:It has been reported that lead could induce apoptosis in a variety of cell types. Although mitochondrion is regarded as the most pertinent pathway in mediating apoptosis, the exact mechanisms of lead-induced apoptosis are still largely unknown. Furthermore, there is little information about expressions and regulations...

journal_title：Toxicology letters

authors： Xu J,Ji LD,Xu LH

更新日期：2006-10-10 00:00:00

abstract：:Most studies on the adverse effects of air pollution have focused on respiratory and cardiovascular diseases, and there are relatively few studies on eye diseases following exposure of ambient particulate matter (PM). Epidemiological and clinical researches correlating the eye and PMs have recently received attention....

journal_title：Toxicology letters

authors： Yoon S,Han S,Jeon KJ,Kwon S

更新日期：2018-03-01 00:00:00

abstract：:Fenvalerate (Fen), widely used for its high insecticidal potency and low mammalian toxicity, is classified as an endocrine-disrupting chemical. Recently, Fen has received great attention for its adverse effects on human reproductive health. In this study, we found that Fen (10 microM) had a stimulatory effect on the g...

journal_title：Toxicology letters

authors： Gao X,Yu L,Castro L,Moore AB,Hermon T,Bortner C,Sifre M,Dixon D

更新日期：2010-07-15 00:00:00

abstract：:A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, we collected information on urinary n-heptane metabolite concentrations and the time course of metabolite excretion. Relationships between external and internal ex...

journal_title：Toxicology letters

authors： Rossbach B,Kegel P,Letzel S

更新日期：2018-12-01 00:00:00

abstract：:Rat and canine hepatocyte suspensions were exposed to toxic concentrations of ethyl methanesulfonate (EMS) and ionophore A-23187 in the presence and absence of extracellular calcium (Ca2+) and alpha-tocopheryl succinate (alpha-TS). The exogenous administration of alpha-TS (25 microM) completely protected hepatocytes f...

journal_title：Toxicology letters

authors： Fariss MW,Merson MH,O'Hara TM

更新日期：1989-04-01 00:00:00

abstract：:Methylglyoxal (MG) is a metabolite of glucose. The serum MG level is increased in diabetic patients, and MG is implicated in diabetic complications related to embryonic development injury. We previously reported cytotoxic effects of MG on mouse embryonic stem cells and blastocysts, and a further association with defec...

journal_title：Toxicology letters

authors： Chang YJ,Chan WH

更新日期：2010-04-01 00:00:00

abstract：:The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...

journal_title：Toxicology letters

authors： Scotti TM,Chernoff N,Linder R,McElroy WK

更新日期：1981-11-01 00:00:00

abstract：:The aim of this study was to determine the toxicokinetics and some effects of 1,1,1-trifluoroethane (HFC-143a) in humans. Nine male volunteers were experimentally exposed to 500ppm HFC-143a for 2h during light physical exercise (50W) in an exposure chamber. Blood, urine and exhaled air were sampled before, during and ...

journal_title：Toxicology letters

authors： Gunnare S,Ernstgård L,Sjögren B,Johanson G

更新日期：2007-08-01 00:00:00

abstract：:Lead (Pb) exposure impairs the nervous system, of which the injury of cognitive development is obvious. But the mechanism of Pb induced disorders of neuro-transmission remain elusive. In this study, primary hippocampal neurons were exposed to Pb at the dosage of 5 μM from days in vitro (DIV) 3 to DIV14 and the electro...

journal_title：Toxicology letters

authors： Ding JJ,Zou RX,He HM,Lou ZY,Xu Y,Wang HL

更新日期：2018-10-15 00:00:00

abstract：:Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and applicat...

journal_title：Toxicology letters

authors： Lautz LS,Dorne JLCM,Oldenkamp R,Hendriks AJ,Ragas AMJ

更新日期：2020-02-01 00:00:00

abstract：:We have examined the effect of subchronic methidathion (MD) administration on vascular wall damage. The experimental groups were: control group and rats treated with 5 mg/kg MD. The MD group was given MD by gavage for 5 days a week for 4 weeks at a dose level of 5 mg/kg per day by using corn oil as the vehicle. The le...

journal_title：Toxicology letters

authors： Yavuz T,Delibas N,Yildirim B,Altuntas I,Candir O,Cora A,Karahan N,Ibrisim E,Kutsal A

更新日期：2005-01-15 00:00:00