Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.

abstract：:The repeated dose toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male and female newborn rats given TBBPA orally at 0, 40, 200, or 600 mg/kg per day for 18 days from 4 days of age until weaning at 21 days of age. Half the rats in each dose group were sacrificed for a full gross necropsy ...

journal_title：Toxicology letters

authors： Fukuda N,Ito Y,Yamaguchi M,Mitumori K,Koizumi M,Hasegawa R,Kamata E,Ema M

更新日期：2004-04-21 00:00:00

abstract：:Chlorpyrifos (CHP), an OP-based pesticide, induces hypothermia in the rat followed by a fever that persists for several days. The cytokine, tumor necrosis factor-alpha (TNF), is induced by lipopolysaccharide (LPS) and released during fever and has both pyrogenic and cryogenic (i.e. antipyretic) properties. Administeri...

journal_title：Toxicology letters

authors： Rowsey PJ,Gordon CJ

更新日期：1999-09-20 00:00:00

abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

journal_title：Toxicology letters

authors： Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

更新日期：1985-10-01 00:00:00

abstract：:Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development of lung cancers have suggested a synergism between arsenit...

journal_title：Toxicology letters

authors： Pang Y,Xu Y,Li H,Li Y,Zhao Y,Jiang R,Shen L,Zhou J,Wang X,Liu Q

更新日期：2013-04-12 00:00:00

abstract：:In Europe and the USA the prevalence of certain forms of allergic disease is rising; an increase that can not be reconciled simply on the basis of changes in diagnostic fashion. The changes observed have been too rapid to be explained by alterations in the gene pool and, as a consequence, there has been a growing inte...

journal_title：Toxicology letters

authors： Kimber I

更新日期：1998-12-28 00:00:00

abstract：:The changes in hepatic metallothionein (MT) and glutathione levels and cadmium distribution were investigated 72 hr after a subcutaneous administration of 1.5 mg Cd2+/kg as CdCl2H2O to normal and partially hepatectomized rats. Partial hepatectomy had no effect on native metallothionein content. Cadmium and MT content ...

journal_title：Toxicology letters

authors： Asokan P

更新日期：1982-06-01 00:00:00

abstract：:The interaction of zinc(II) on the toxicokinetics of 2,5-hexanedione (2,5-HD), the ultimate toxic metabolite of n-hexane, was performed by quantifying the changes of two urinary biomarkers, free 2,5-HD and pyrrole derivatives, in rats exposed to 2,5-HD and to 2,5-HD plus zinc acetate. Eight groups of Wistar rats were ...

journal_title：Toxicology letters

authors： Mateus ML,dos Santos AP,Batoréu MC

更新日期：2001-02-03 00:00:00

abstract：:We observed transient excretion of dark-brown urine after acute exposure to cobalt in rats and investigated the mechanism of it. We injected cobalt into rats s.c. at a dose of 15 mg/kg and collected urine, peripheral blood, and organ samples at the indicated times after injection. Biochemical and histopathological exa...

journal_title：Toxicology letters

authors： Horiguchi H,Oguma E,Nomoto S,Arao Y,Ikeda K,Kayama F

更新日期：2004-08-01 00:00:00

abstract：:Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...

journal_title：Toxicology letters

authors： Mou Z,Yuan YH,Zhang Z,Song LK,Chen NH

更新日期：2020-05-15 00:00:00

abstract：:The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous soluti...

journal_title：Toxicology letters

authors： Baranowska-Dutkeiwicz B

更新日期：1982-03-01 00:00:00

abstract：:To investigate mechanisms of neuronal cell death in response to chlorpyrifos (CPF), a pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH-SY5Y cells treated with CPF. CPF treatment produced cytotoxic effects that appeared to involve an increase in ROS. In addition, CPF treatment activated...

journal_title：Toxicology letters

authors： Ki YW,Park JH,Lee JE,Shin IC,Koh HC

更新日期：2013-04-26 00:00:00

abstract：:This study involved an attempt to establish a new photosafety screening system for dermally-applied chemicals consisting of a reactive oxygen species (ROS) assay and an in vitro skin permeation test. The ROS assay was undertaken to evaluate photoreactivity of six test compounds, acridine (ACD), furosemide (FSM), hexac...

journal_title：Toxicology letters

authors： Iyama Y,Sato H,Seto Y,Onoue S

更新日期：2019-12-15 00:00:00

abstract：:Zinc chloride (0.01 mM kept for 3h) is not toxic to cultured cerebellar granule neurons (CGNs) while kainate (0.1mM kept for 3h) demonstrates some but very low toxicity towards these cells. Measurements of the relative intraneuronal zinc ion concentration showed that increase in [Zn(2+)](i) under the simultaneous acti...

journal_title：Toxicology letters

authors： Lozier ER,Stelmashook EV,Uzbekov RE,Novikova SV,Zorov SD,Alieva IB,Arbeille B,Zorov DB,Isaev NK

更新日期：2012-01-05 00:00:00

abstract：:The effects of four phthalates, i.e., di-2-ethylhexyl phthalate (DEHP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP) and diisobutyl phthalate (DIBP) on necrotic and apoptotic cell death, and production of reactive oxygen species (ROS) were studied on mouse macrophage cell line RAW 264.7. All the phthalates ca...

journal_title：Toxicology letters

authors： Naarala J,Korpi A

更新日期：2009-07-24 00:00:00

abstract：:Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. In China, it has also been employed in herbal remedies for hepatitis and abdominal edema. Since E. milii latex--lyophilized or in natura--proved to be a potent plant molluscicide, its toxicity to non-target organisms has been comp...

journal_title：Toxicology letters

authors： Delgado IF,De-Carvalho RR,De-Oliveira AC,Kuriyama SN,Oliveira-Filho EC,Souza CA,Paumgartten FJ

更新日期：2003-11-30 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:Combined effects of mycotoxin mixtures are of major concern due to the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon the fu...

journal_title：Toxicology letters

authors： Tammer B,Lehmann I,Nieber K,Altenburger R

更新日期：2007-04-25 00:00:00

abstract：:The aim of this study was to establish an air-liquid interface (ALI) culture of precision-cut lung slices (PCLS) for direct exposure of lung cells to gaseous contaminants. Nitrogen dioxide (NO(2)) and ozone (O(3)) were selected as model gas compounds. Acute pro-inflammatory and toxic effects of NO(2) and O(3) on live ...

journal_title：Toxicology letters

authors： Switalla S,Knebel J,Ritter D,Krug N,Braun A,Sewald K

更新日期：2010-07-01 00:00:00

abstract：:Nitrogen mustard (HN-2), also known as mechlorethamine, is an alkylating anticancer agent as well as blister inducing chemical warfare agent. We evaluated the cytoprotective efficacy of amifostine, DRDE-07 and their analogues, and other antidotes of mustard agents against HN-2. Administration of 1 LD(50) of HN-2 (20mg...

journal_title：Toxicology letters

authors： Sharma M,Vijayaraghavan R,Gautam A

更新日期：2009-08-10 00:00:00

abstract：:Lanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a result, more and more lanthanides are entering into the environment and eventually accumulated in human body. Recently, a new medicine, lanthanum carbonate (Fosrenol), has been used to treat chron...

journal_title：Toxicology letters

authors： Feng L,Xiao H,He X,Li Z,Li F,Liu N,Zhao Y,Huang Y,Zhang Z,Chai Z

更新日期：2006-08-20 00:00:00

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. This spectral map is affected by th...

journal_title：Toxicology letters

authors： Ryan SE,Nguyen HP,Baenziger JE

更新日期：1998-11-23 00:00:00

abstract：:Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...

journal_title：Toxicology letters

authors： Kulshrestha SK,Arora N

更新日期：1984-01-01 00:00:00

abstract：:Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 microm and particularly the fine fraction (PM-2.5) smaller than 2.5 microm are responsible for adverse health effects, causing an increasing morbidity and mortality. Fu...

journal_title：Toxicology letters

authors： Hornberg C,Maciuleviciute L,Seemayer NH,Kainka E

更新日期：1998-08-01 00:00:00

abstract：:Primary renal neoplasms in the rats are uncommon. Nephroblastoma is the only renal embryonal tumor of the rat; all other tumors are reported in older rats. The occurrence of spontaneous nephroblastoma in rats has been reported. However, metastasis from the nephroblastoma in rat is extremely rare. Data from 2669 Spragu...

journal_title：Toxicology letters

authors： Chandra M,Carlton WW

更新日期：1992-09-01 00:00:00

abstract：:Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final ma...

journal_title：Toxicology letters

authors： Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

更新日期：2000-03-15 00:00:00

abstract：:Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1...

journal_title：Toxicology letters

authors： Kobayashi S,Sata F,Sasaki S,Ban S,Miyashita C,Okada E,Limpar M,Yoshioka E,Kajiwara J,Todaka T,Saijo Y,Kishi R

更新日期：2013-06-07 00:00:00

abstract：:Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strate...

journal_title：Toxicology letters

authors： Ferraguti G,Ciolli P,Carito V,Battagliese G,Mancinelli R,Ciafrè S,Tirassa P,Ciccarelli R,Cipriani A,Messina MP,Fiore M,Ceccanti M

更新日期：2017-06-05 00:00:00

abstract：:There is accumulating evidence that both type I and type II DNA-topoisomerases play a key role in cellular differentiation. Human HL-60 leukemia cells can be induced to monocytic or granulocytic differentiation with various compounds; amongst them camptothecin, a topoisomerase I inhibitor and VP-16, VM-26 and mitoxant...

journal_title：Toxicology letters

authors： Gieseler F,Boege F,Clark M,Meyer P

更新日期：1993-04-01 00:00:00

abstract：:In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of...

journal_title：Toxicology letters

authors： Löschinger M,Thumm S,Hämmerle H,Rodemann HP

更新日期：1998-08-01 00:00:00