Abstract：
:Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final manifestation of a multistep pathway, resulting in an imbalance between cell proliferation and cell death by apoptosis. The impact of certain confounding factors e.g. extent of inflammatory response, type of genotoxic event, antagonizing principles and genetic background are discussed in this article. Finally, methods to assess the inflammatory potential of chemicals are referred to.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich Udoi
10.1016/s0378-4274(99)00285-4keywords:
subject
Has Abstractpub_date
2000-03-15 00:00:00pages
185-91eissn
0378-4274issn
1879-3169pii
S0378427499002854journal_volume
112-113pub_type
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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doi：10.1016/j.toxlet.2014.09.008
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.02.021
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journal_title：Toxicology letters
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.07.004
更新日期：2009-10-28 00:00:00
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journal_title：Toxicology letters
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.11.034
更新日期：2014-02-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.03.031
更新日期：2018-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.10.002
更新日期：2004-01-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Toxicology letters
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doi：10.1016/j.toxlet.2011.10.018
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2007-03-08 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.04.016
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.08.023
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90187-5
更新日期：1984-01-01 00:00:00
abstract：:International scientific committees, regional scientific committees such as those of the European Union, and national regulatory agencies generally use the uncertainly factor approach for establishing acceptable or tolerable intakes of substances that exhibit thresholds of toxicity. No observed adverse effect levels (...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2008.06.003
更新日期：2008-08-15 00:00:00
abstract：:Testicular Leydig cells express estrogen receptors and are the predominant source of the male sex steroid hormone testosterone (T). Previous studies demonstrated that genistein acts through estrogen receptors in Leydig cells. In the present study, pre-treatment of Leydig cells isolated from 35 day-old male Long Evans ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.11.005
更新日期：2009-02-10 00:00:00
abstract：:Particulate air pollution is associated with cardiovascular morbidity and mortality. Fine particles with a diameter <2.5 microm (PM2.5) have an important role in triggering biological responses. These particles, and particularly the ultrafine fraction (<100 nm) penetrate deeply into the respiratory tract. Recently, we...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.12.061
更新日期：2004-04-01 00:00:00
