Abstract:
:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellular levels of alpha-tocopherol and glutathione. At the time of maximum detectable oxidation (3 h), after the injection of a sublethal dose of Fe-NTA there were clear reductions in the peak values over the controls for several fatty acids notably, 20:5 (eicosapentaenoic acid) (36%), 22:6 (docosahexanoic acid) (30%), 20:3 n6 (eicosatrienoic acid) (30%) and 20:4 (arachidonic acid) (28%) in the kidney. Fewer fatty acids showed a reduction in their residual values in the liver. 20:5 was reduced by 45% and for the 18:3 n3 and 18:3 n6, reductions of 35%, respectively. The profile of PUFAs is sensitive to the oxidative damage due to Fe-NTA and this may find applications as oxidative biomarker model.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MAdoi
10.1016/s0378-4274(01)00372-1keywords:
subject
Has Abstractpub_date
2001-09-15 00:00:00pages
125-33issue
2-3eissn
0378-4274issn
1879-3169pii
S0378-4274(01)00372-1journal_volume
123pub_type
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