Abstract：
:Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investigate the mechanism behind the suppression of antibody production. IND was orally administered to pregnant SD rats on days 18-21 of gestation. After parturition, the spleen cells isolated from 3-week-old pups were incubated with concanavalin A (Con A) or lipopolysaccharide (LPS). The level of cytokines in the culture supernatant was measured. IL-10 decreased significantly in the males, and IL-6 and TNF-alpha tended to decrease in both sexes. In order to examine the effect of IND on cytokine production in juvenile rats in vitro, spleen cells isolated from untreated 3-week-old rats were exposed to IND and a mitogen (Con A or LPS) simultaneously, and then the levels of cytokines were measured. IL-4 decreased in the males, and IL-6 tended to decrease in both sexes. These results indicated that treating dams with IND during late gestation causes a change in the release of Th2 cytokine, and suggested that this change involves the suppression of antibody production.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kushima K,Sakuma S,Furusawa S,Fujiwara Mdoi
10.1016/j.toxlet.2008.11.013subject
Has Abstractpub_date
2009-02-25 00:00:00pages
32-7issue
1eissn
0378-4274issn
1879-3169pii
S0378-4274(08)01356-8journal_volume
185pub_type
杂志文章abstract：:The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90137-5
更新日期：1981-04-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(87)90140-8
更新日期：1987-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90082-3
更新日期：1988-05-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00183-0
更新日期：1998-11-23 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(00)00277-0
更新日期：2001-01-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.04.010
更新日期：2011-09-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90123-x
更新日期：1980-09-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(03)00113-9
更新日期：2003-06-05 00:00:00
abstract：:Nerve agent toxicity is primarily due to the synaptic build up of toxic levels of acetylcholine. The acute lethal effects of the nerve agents are generally attributed to respiratory failure caused by a combination of effects at both central and peripheral levels and are further complicated by copious secretions, muscl...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2012-01-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.12.012
更新日期：2017-02-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90062-0
更新日期：1983-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90057-7
更新日期：1983-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.02.009
更新日期：2004-05-02 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.07.021
更新日期：2016-09-30 00:00:00
abstract：:Colistin is a polypeptide antibiotic that effectively treats infections caused by multidrug-resistant Gram-negative bacteria, but its clinical use is limited due to nephrotoxicity. The purpose of the present study was to identify biomarkers of colistin-induced nephrotoxicity and to further characterize the mechanisms ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.02.018
更新日期：2016-04-25 00:00:00
abstract：:Autophagy, which works to remove stress and maintain cellular homeostasis, is usually considered a "pro-survival" signal. Contrarily, apoptosis is programmed "pro-death" machinery. Polychlorinated biphenyls (PCBs) are a group of ubiquitous industrial pollutants. Our previous studies illustrated that a PCB quinone meta...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.02.002
更新日期：2019-05-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.07.010
更新日期：2012-09-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1988-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：1995-09-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2004.04.043
更新日期：2004-10-10 00:00:00
abstract：:The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.06.036
更新日期：2014-09-17 00:00:00
abstract：:Vinyl acetate exposure in drinking water has been associated with tumor formation in the upper gastrointestinal tract of rats and mice. One potential mechanism for inducing carcinogenesis involves acidification of the intracellular environment due to the metabolism of vinyl acetate to acetic acid. Prolonged intracellu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.03.002
更新日期：2005-08-14 00:00:00
abstract：:Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.07.006
更新日期：2019-10-10 00:00:00
abstract：:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(91)90198-f
更新日期：1991-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.03.031
更新日期：2018-12-01 00:00:00
abstract：:A number of studies have demonstrated that co-exposure to low levels of melamine and cyanuric acid elicits renal toxicity due to the formation of melamine cyanurate crystals in the kidney nephrons. In this work, we investigated if co-exposure of rats to these compounds leads to alterations in the expression of the gen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.07.009
更新日期：2011-10-10 00:00:00
