Anesthetic-induced structural changes in the nicotinic acetylcholine receptor.

Abstract:

:The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. This spectral map is affected by the presence of either the local anesthetic, dibucaine, or the short chain alcohol, propanol. Both antagonists alter the intensities of difference bands in a manner consistent with the stabilization of a desensitized state. Spectral variations are also observed that are indicative of both the displacement of the anesthetics from the nAChR upon the addition of Carb and physical interactions that occur between the anesthetics and binding site residues.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Ryan SE,Nguyen HP,Baenziger JE

doi

10.1016/s0378-4274(98)00183-0

keywords:

subject

Has Abstract

pub_date

1998-11-23 00:00:00

pages

179-83

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(98)00183-0

journal_volume

100-101

pub_type

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